Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRNP
  • Mouse genes Prnp
  • Rat genes Prnp
  • Zfish genes prnpa,prnpb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prnp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	PRNP	IPI	CHEBI:64647	Human	PMID:22820466
Molecular Function	GO:0001540	amyloid-beta binding	PRNP	IDA		Human	PMID:24012003
Molecular Function	GO:0001540	amyloid-beta binding	Prnp	IDA		Mouse	MGI:MGI:3836364|PMID:19242475
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	Prnp	IDA		Mouse	MGI:MGI:3714552|PMID:17573534
Molecular Function	GO:0043008	ATP-dependent protein binding	Prnp	IPI	RGD:620516	Rat	PMID:16774738|RGD:4891437
Molecular Function	GO:0005507	copper ion binding	PRNP	IDA		Human	PMID:11900542
Molecular Function	GO:0005507	copper ion binding	Prnp	IDA		Mouse	PMID:12500977
Molecular Function	GO:0005507	copper ion binding	prnpa	IDA		Zfish	PMID:18942875
Molecular Function	GO:1903135	cupric ion binding	Prnp	IMP		Mouse	MGI:MGI:5882881|PMID:19381258
Molecular Function	GO:1903136	cuprous ion binding	PRNP	IMP		Human	PMID:20564047
Molecular Function	GO:0005539	glycosaminoglycan binding	Prnp	IDA		Mouse	MGI:MGI:3714552|PMID:17573534
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:16286452
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:18025469
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:18436646
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:19204296
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:19278656
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:19927125
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:20564047
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:21920025
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:32284600
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:32514176
Molecular Function	GO:0042802	identical protein binding	PRNP	IPI	UniProtKB:P04156	Human	PMID:34516876
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5919178|PMID:21441913
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5508565|PMID:20345906
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:6392941|PMID:22854022
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:6092920|PMID:19805070
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5512941|PMID:22449963
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5510275|PMID:23892077
Molecular Function	GO:0042802	identical protein binding	Prnp	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5917947|PMID:21041683
Molecular Function	GO:0005521	lamin binding	Prnp	IPI	RGD:620522	Rat	PMID:21277044|RGD:10044248
Molecular Function	GO:0046872	metal ion binding	Prnp	IDA		Mouse	MGI:MGI:7310010|PMID:11438695
Molecular Function	GO:0046872	metal ion binding	Prnp	EXP		Mouse	MGI:MGI:7310010|PMID:11438695
Molecular Function	GO:0008017	microtubule binding	PRNP	IDA		Human	PMID:16004966
Molecular Function	GO:0060090	molecular adaptor activity	PRNP	IDA		Human	PMID:30401430
Molecular Function	GO:0060090	molecular adaptor activity	Prnp	EXP		Mouse	MGI:MGI:6159524|PMID:29791485
Molecular Function	GO:0060090	molecular adaptor activity	Prnp	IPI	UniProtKB:P37840	Mouse	MGI:MGI:6116610|PMID:28945221
Molecular Function	GO:0140693	molecular condensate scaffold activity	PRNP	IDA		Human	PMID:30401430
Molecular Function	GO:0140693	molecular condensate scaffold activity	Prnp	IDA		Mouse	MGI:MGI:6720113|PMID:34102212
Molecular Function	GO:0140693	molecular condensate scaffold activity	Prnp	EXP		Mouse	MGI:MGI:6720113|PMID:34102212
Molecular Function	GO:0002020	protease binding	Prnp	IPI	UniProtKB:P56817	Mouse	MGI:MGI:3714552|PMID:17573534
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P05067	Human	PMID:16286452
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P29372	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P49639	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q13642	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q9BSJ6	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q9H4B4	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q9UL18	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P10279	Human	PMID:21920025
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P04925	Human	PMID:22285492
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P10279	Human	PMID:22285492
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P23907	Human	PMID:22285492
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q8CJG0	Human	PMID:22484317
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q9UKV8	Human	PMID:22484317
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q9UL18	Human	PMID:22484317
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P05067-4	Human	PMID:23236467
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:23907583
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P05067	Human	PMID:24028865
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P10636	Human	PMID:24028865
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:O75084	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P55085	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:28650319
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P25311	Human	PMID:28671123
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q06830	Human	PMID:28671123
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q13642	Human	PMID:28671123
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q8N6K7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PRNP	IPI	UniProtKB:Q8WXF7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:P04156	Mouse	MGI:MGI:5512942|PMID:22285492
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:P05067	Mouse	MGI:MGI:3836364|PMID:19242475
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5512962|PMID:15301538
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:P12023:PRO_0000000118	Mouse	MGI:MGI:3836364|PMID:19242475
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:O08532	Mouse	MGI:MGI:5440396|PMID:22542184
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:P37840	Mouse	MGI:MGI:6116610|PMID:28945221
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:Q6F3F9	Mouse	MGI:MGI:5806682|PMID:27501152
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:P10636	Mouse	MGI:MGI:6267587|PMID:30355631
Molecular Function	GO:0005515	protein binding	Prnp	IPI	UniProtKB:P12023:PRO_0000000118	Mouse	MGI:MGI:4431092|PMID:20133875
Molecular Function	GO:0005515	protein binding	Prnp	IPI	MGI:MGI:88385	Mouse	PMID:29070671
Molecular Function	GO:0005515	protein binding	Prnp	IPI	PR:Q9Z218	Mouse	PMID:24225951
Molecular Function	GO:0005515	protein binding	Prnp	IPI	PR:Q60631	Mouse	PMID:11571277
Molecular Function	GO:0005515	protein binding	Prnp	IPI	PR:Q8C460	Mouse	PMID:11571277
Molecular Function	GO:0005515	protein binding	Prnp	IPI	PR:O88935-1	Mouse	PMID:11571277
Molecular Function	GO:0140311	protein sequestering activity	Prnp	IDA		Mouse	MGI:MGI:5002743|PMID:21441896
Molecular Function	GO:0044877	protein-containing complex binding	PRNP	IPI	ComplexPortal:CPX-1134	Human	PMID:23386614
Molecular Function	GO:0044877	protein-containing complex binding	Prnp	IPI	ComplexPortal:CPX-1139	Mouse	MGI:MGI:3836364|PMID:19242475
Molecular Function	GO:0051087	protein-folding chaperone binding	Prnp	IPI	RGD:620516	Rat	PMID:16774738|RGD:4891437
Molecular Function	GO:0051087	protein-folding chaperone binding	Prnp	IPI	RGD:71001	Rat	PMID:16774738|RGD:4891437
Molecular Function	GO:0038023	signaling receptor activity	Prnp	IMP		Mouse	MGI:MGI:3836364|PMID:19242475
Molecular Function	GO:0004784	superoxide dismutase activity	prnpa	IDA		Zfish	PMID:19586023
Molecular Function	GO:0044325	transmembrane transporter binding	Prnp	IPI	RGD:621448	Rat	PMID:16750514|RGD:9831180
Molecular Function	GO:0015631	tubulin binding	PRNP	IDA		Human	PMID:16004966
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	PRNP	IPI	UniProtKB:P41594	Human	PMID:24012003
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	Prnp	IPI	UniProtKB:Q3UVX5	Mouse	MGI:MGI:5515653|PMID:24012003
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	Prnp	IPI	UniProtKB:P31424	Rat	PMID:24012003|RGD:8553716
Cellular Component	GO:0009986	cell surface	PRNP	IDA		Human	PMID:18419754
Cellular Component	GO:0009986	cell surface	PRNP	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	Prnp	IDA		Mouse	PMID:16254249
Cellular Component	GO:0009986	cell surface	prnpb	IDA		Zfish	PMID:16414019
Cellular Component	GO:0005737	cytoplasm	Prnp	IDA		Rat	PMID:17146448|RGD:1599950
Cellular Component	GO:0005829	cytosol	PRNP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	PRNP	IDA		Human	PMID:24012003
Cellular Component	GO:0030425	dendrite	Prnp	IDA		Mouse	MGI:MGI:3836364|PMID:19242475
Cellular Component	GO:0005783	endoplasmic reticulum	Prnp	IDA		Mouse	PMID:11756421
Cellular Component	GO:0070062	extracellular exosome	PRNP	HDA		Human	PMID:19056867
Cellular Component	GO:0005794	Golgi apparatus	Prnp	IDA		Mouse	PMID:11756421
Cellular Component	GO:0016234	inclusion body	PRNP	IMP		Human	PMID:20564047
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PRNP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Prnp	IDA		Mouse	PMID:24225951
Cellular Component	GO:0016020	membrane	Prnp	IDA		Rat	PMID:16774738|RGD:4891437
Cellular Component	GO:0045121	membrane raft	PRNP	IDA		Human	PMID:16254249
Cellular Component	GO:0045121	membrane raft	PRNP	IMP		Human	PMID:23386614
Cellular Component	GO:0045121	membrane raft	Prnp	IMP		Mouse	MGI:MGI:3714552|PMID:17573534
Cellular Component	GO:0045121	membrane raft	Prnp	IDA		Mouse	PMID:12927782
Cellular Component	GO:0045121	membrane raft	Prnp	IDA		Mouse	PMID:10037495
Cellular Component	GO:0031965	nuclear membrane	PRNP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PRNP	IDA		Human	PMID:16254249
Cellular Component	GO:0005886	plasma membrane	PRNP	IDA		Human	PMID:18419754
Cellular Component	GO:0005886	plasma membrane	Prnp	IDA		Mouse	MGI:MGI:4821089|PMID:9837873
Cellular Component	GO:0005886	plasma membrane	Prnp	IDA		Rat	PMID:16248888|RGD:1599959
Cellular Component	GO:0005886	plasma membrane	prnpb	IDA		Zfish	PMID:19278297
Cellular Component	GO:0014069	postsynaptic density	Prnp	IDA		Rat	PMID:22820466|RGD:12790652
Cellular Component	GO:0043195	terminal bouton	Prnp	IDA		Mouse	MGI:MGI:3050900|PMID:15262264
Biological Process	GO:0032147	activation of protein kinase activity	Prnp	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5882868|PMID:23386614
Biological Process	GO:0034334	adherens junction maintenance	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-4,ZFIN:ZDB-MRPHLNO-100423-5	Zfish	PMID:26860872
Biological Process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-4	Zfish	PMID:19278297
Biological Process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-5	Zfish	PMID:19278297
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	PRNP	IGI	UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	Prnp	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5515653|PMID:24012003
Biological Process	GO:1904646	cellular response to amyloid-beta	PRNP	IGI	UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:1904646	cellular response to amyloid-beta	Prnp	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5515653|PMID:24012003
Biological Process	GO:0071280	cellular response to copper ion	PRNP	IDA		Human	PMID:16254249
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Prnp	IDA		Mouse	PMID:16254249
Biological Process	GO:0007417	central nervous system development	prnpb	IGI	ZFIN:ZDB-MRPHLNO-100423-4,ZFIN:ZDB-MRPHLNO-130125-1	Zfish	PMID:23236467
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-4	Zfish	PMID:19278297
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	prnpb	IGI	ZFIN:ZDB-MRPHLNO-050421-1,ZFIN:ZDB-MRPHLNO-100423-4	Zfish	PMID:19278297
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-5	Zfish	PMID:19278297
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	prnpb	IDA		Zfish	PMID:19278297
Biological Process	GO:0007611	learning or memory	Prnp	IGI	UniProtKB:P12023,UniProtKB:P49769	Mouse	MGI:MGI:4454612|PMID:20445063
Biological Process	GO:0007611	learning or memory	Prnp	IMP		Rat	PMID:17156386|RGD:1599949
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	Prnp	IGI	UniProtKB:P12023	Mouse	MGI:MGI:3714552|PMID:17573534
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Prnp	IGI	UniProtKB:P12023	Mouse	MGI:MGI:3714552|PMID:17573534
Biological Process	GO:0043066	negative regulation of apoptotic process	Prnp	IGI	MGI:MGI:99702	Mouse	PMID:15753097
Biological Process	GO:0043066	negative regulation of apoptotic process	Prnp	IMP		Rat	PMID:16766127|RGD:1599953
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:0043086	negative regulation of catalytic activity	Prnp	IDA		Rat	PMID:23386614|RGD:12910992
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	Prnp	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5515653|PMID:24012003
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	Prnp	IGI	UniProtKB:P39688,UniProtKB:Q01097	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Prnp	IDA		Rat	PMID:21593310|RGD:12790639
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:0032689	negative regulation of type II interferon production	Prnp	IMP		Mouse	MGI:MGI:4943618|PMID:20145049
Biological Process	GO:1990535	neuron projection maintenance	Prnp	IGI	UniProtKB:P12023,UniProtKB:P49769	Mouse	MGI:MGI:4454612|PMID:20445063
Biological Process	GO:0010942	positive regulation of cell death	Prnp	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5882868|PMID:23386614
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	PRNP	IMP		Human	PMID:20564047
Biological Process	GO:1901216	positive regulation of neuron death	Prnp	IGI	UniProtKB:P39688,UniProtKB:Q01097	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PRNP	IDA		Human	PMID:22820466
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Prnp	IMP		Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Prnp	IMP		Mouse	MGI:MGI:5882868|PMID:23386614
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Prnp	IMP		Rat	PMID:23386614|RGD:12910992
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Prnp	IGI	UniProtKB:P39688	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	PRNP	IGI	ComplexPortal:CPX-1134,UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:0031648	protein destabilization	PRNP	IMP		Human	PMID:20564047
Biological Process	GO:1905664	regulation of calcium ion import across plasma membrane	Prnp	IGI	UniProtKB:P39688	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-5	Zfish	PMID:19278297
Biological Process	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-4	Zfish	PMID:19278297
Biological Process	GO:1900449	regulation of glutamate receptor signaling pathway	Prnp	IGI	UniProtKB:P39688	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:1902938	regulation of intracellular calcium activated chloride channel activity	PRNP	IGI	ComplexPortal:CPX-1134,UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Prnp	IGI	UniProtKB:P39688	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	Prnp	IGI	MGI:MGI:94921	Mouse	PMID:24225951
Biological Process	GO:0032880	regulation of protein localization	Prnp	IMP		Mouse	PMID:10037495
Biological Process	GO:0061097	regulation of protein tyrosine kinase activity	prnpb	IMP	ZFIN:ZDB-MRPHLNO-100423-4,ZFIN:ZDB-MRPHLNO-100423-5	Zfish	PMID:26860872
Biological Process	GO:1904645	response to amyloid-beta	Prnp	IGI	UniProtKB:P39688	Mouse	MGI:MGI:5447900|PMID:22820466
Biological Process	GO:0046686	response to cadmium ion	Prnp	IDA		Rat	PMID:16148034|RGD:1599958
Biological Process	GO:0046688	response to copper ion	Prnp	IDA		Rat	PMID:16148034|RGD:1599958
Biological Process	GO:0006979	response to oxidative stress	Prnp	IDA		Mouse	PMID:12500977

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern