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Gene Ontology Browser
Term Detail
GO term:negative regulation of catalytic activity
Synonym: down regulation of enzyme activity
Synonym: down-regulation of enzyme activity
Synonym: downregulation of enzyme activity
Synonym: inhibition of enzyme activity
Synonym: negative regulation of enzyme activity
GO id:GO:0043086
Definition:Any process that stops or reduces the activity of an enzyme.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of catalytic activity
                                                is-amodulation of catalytic activity in other organism involved in symbiotic interaction +
                                                is-anegative regulation of catalytic activity [GO:0043086] (622 genes, 834 annotations)
                                                        is-anegative regulation of catalytic activity in other organism involved in symbiotic interaction +
                                                        is-anegative regulation of cyclase activity +
                                                        is-anegative regulation of hydrolase activity +
                                                        is-anegative regulation of ligase activity +
                                                        is-anegative regulation of lyase activity +
                                                        is-anegative regulation of metalloenzyme activity
                                                        is-anegative regulation of oxidoreductase activity +
                                                        is-anegative regulation of prostaglandin-E synthase activity
                                                        is-anegative regulation of transferase activity +
                                                is-apositive regulation of catalytic activity +
                                                is-aregulation of cyclase activity +
                                                is-aregulation of hydrolase activity +
                                                is-aregulation of isomerase activity +
                                                is-aregulation of ligase activity +
                                                is-aregulation of lyase activity +
                                                is-aregulation of metalloenzyme activity +
                                                is-aregulation of oxidoreductase activity +
                                                is-aregulation of transferase activity +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-anegative regulation of molecular function
                                        is-anegative regulation of binding +
                                        is-anegative regulation of catalytic activity [GO:0043086] (622 genes, 834 annotations)
                                                is-anegative regulation of catalytic activity in other organism involved in symbiotic interaction +
                                                is-anegative regulation of cyclase activity +
                                                is-anegative regulation of hydrolase activity +
                                                is-anegative regulation of ligase activity +
                                                is-anegative regulation of lyase activity +
                                                is-anegative regulation of metalloenzyme activity
                                                is-anegative regulation of oxidoreductase activity +
                                                is-anegative regulation of prostaglandin-E synthase activity
                                                is-anegative regulation of transferase activity +
                                        is-anegative regulation of ligand-dependent nuclear receptor transcription coactivator activity
                                        is-anegative regulation of molecular function in other organism +
                                        is-anegative regulation of molecular function, epigenetic
                                        is-anegative regulation of receptor activity +
                                        is-anegative regulation of Rho guanyl-nucleotide exchange factor activity
                                        is-anegative regulation of sequence-specific DNA binding transcription factor activity +
                                        is-anegative regulation of transporter activity +
                                        is-apositive regulation of molecular function in other organism +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of molecular function
                                is-aregulation of catalytic activity
                                        is-amodulation of catalytic activity in other organism involved in symbiotic interaction +
                                        is-anegative regulation of catalytic activity [GO:0043086] (622 genes, 834 annotations)
                                                is-anegative regulation of catalytic activity in other organism involved in symbiotic interaction +
                                                is-anegative regulation of cyclase activity +
                                                is-anegative regulation of hydrolase activity +
                                                is-anegative regulation of ligase activity +
                                                is-anegative regulation of lyase activity +
                                                is-anegative regulation of metalloenzyme activity
                                                is-anegative regulation of oxidoreductase activity +
                                                is-anegative regulation of prostaglandin-E synthase activity
                                                is-anegative regulation of transferase activity +
                                        is-apositive regulation of catalytic activity +
                                        is-aregulation of cyclase activity +
                                        is-aregulation of hydrolase activity +
                                        is-aregulation of isomerase activity +
                                        is-aregulation of ligase activity +
                                        is-aregulation of lyase activity +
                                        is-aregulation of metalloenzyme activity +
                                        is-aregulation of oxidoreductase activity +
                                        is-aregulation of transferase activity +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-amodulation of catalytic activity in other organism involved in symbiotic interaction +
                                        is-anegative regulation of catalytic activity [GO:0043086] (622 genes, 834 annotations)
                                                is-anegative regulation of catalytic activity in other organism involved in symbiotic interaction +
                                                is-anegative regulation of cyclase activity +
                                                is-anegative regulation of hydrolase activity +
                                                is-anegative regulation of ligase activity +
                                                is-anegative regulation of lyase activity +
                                                is-anegative regulation of metalloenzyme activity
                                                is-anegative regulation of oxidoreductase activity +
                                                is-anegative regulation of prostaglandin-E synthase activity
                                                is-anegative regulation of transferase activity +
                                        is-apositive regulation of catalytic activity +
                                        is-aregulation of cyclase activity +
                                        is-aregulation of hydrolase activity +
                                        is-aregulation of isomerase activity +
                                        is-aregulation of ligase activity +
                                        is-aregulation of lyase activity +
                                        is-aregulation of metalloenzyme activity +
                                        is-aregulation of oxidoreductase activity +
                                        is-aregulation of transferase activity +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of catalytic activity
                                        is-amodulation of catalytic activity in other organism involved in symbiotic interaction +
                                        is-anegative regulation of catalytic activity [GO:0043086] (622 genes, 834 annotations)
                                                is-anegative regulation of catalytic activity in other organism involved in symbiotic interaction +
                                                is-anegative regulation of cyclase activity +
                                                is-anegative regulation of hydrolase activity +
                                                is-anegative regulation of ligase activity +
                                                is-anegative regulation of lyase activity +
                                                is-anegative regulation of metalloenzyme activity
                                                is-anegative regulation of oxidoreductase activity +
                                                is-anegative regulation of prostaglandin-E synthase activity
                                                is-anegative regulation of transferase activity +
                                        is-apositive regulation of catalytic activity +
                                        is-aregulation of cyclase activity +
                                        is-aregulation of hydrolase activity +
                                        is-aregulation of isomerase activity +
                                        is-aregulation of ligase activity +
                                        is-aregulation of lyase activity +
                                        is-aregulation of metalloenzyme activity +
                                        is-aregulation of oxidoreductase activity +
                                        is-aregulation of transferase activity +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory