Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLG
  • Mouse genes Plg
  • Rat genes Plg
  • Zfish genes plg
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034185	apolipoprotein binding	PLG	IPI	UniProtKB:P02749	Human	PMID:16480936
Molecular Function	GO:0004175	endopeptidase activity	PLG	IDA		Human	PMID:9603964
Molecular Function	GO:0004175	endopeptidase activity	Plg	IDA		Rat	PMID:12928439|RGD:1299253
Molecular Function	GO:0004175	endopeptidase activity	Plg	IDA		Rat	PMID:7864083|RGD:2301095
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P06733	Human	PMID:12666133
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q7YZX3	Human	PMID:12818429
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P30575	Human	PMID:12867553
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q3Y454	Human	PMID:14688145
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q7DDK4	Human	PMID:17307854
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q9JZ53	Human	PMID:17307854
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WGV1	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WGV3	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WHH9	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WKK7	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WN39	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WQA3	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WQN9	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WQP1	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P9WQP3	Human	PMID:17849409
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:D5H2W5	Human	PMID:17892475
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q2G028	Human	PMID:17892475
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q74J64	Human	PMID:17892475
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q74K78	Human	PMID:17892475
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q8DTS9	Human	PMID:17964283
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q5EFD8	Human	PMID:18070902
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:K1J238	Human	PMID:19270100
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:P06733	Human	PMID:19433310
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:A0A0L0LUA6	Human	PMID:19574304
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:A0A151CBU1	Human	PMID:19574304
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:B7GTK2	Human	PMID:19574304
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:Q45RT9	Human	PMID:19574304
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:A0A348AAL1	Human	PMID:20727989
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:A0A4Y1WAR4	Human	PMID:20727989
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:O51312	Human	PMID:22025510
Molecular Function	GO:0019899	enzyme binding	PLG	IPI	UniProtKB:O51312	Human	PMID:22087329
Molecular Function	GO:0019899	enzyme binding	Plg	IPI	UniProtKB:P04764	Rat	PMID:7964722|RGD:12792993
Molecular Function	GO:0019900	kinase binding	PLG	IPI	UniProtKB:Q04LZ5	Human	PMID:24196407
Molecular Function	GO:0019900	kinase binding	Plg	IPI	UniProtKB:Q04LZ5	Mouse	MGI:MGI:5887190|PMID:24196407
Molecular Function	GO:1990405	protein antigen binding	PLG	IPI	UniProtKB:P9WQN7	Human	PMID:17849409
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P06576	Human	PMID:10077593
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P25705	Human	PMID:10077593
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q4VCS5	Human	PMID:11257124
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P00779	Human	PMID:12456874
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:O13289	Human	PMID:12622818
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P08697	Human	PMID:134998
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q6V4L1	Human	PMID:16319056
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q6V4L4	Human	PMID:16319056
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q6V4L5	Human	PMID:16319056
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q6V4L9	Human	PMID:16319056
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P02749	Human	PMID:16480936
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:I3QNS9	Human	PMID:17557824
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q9KK62	Human	PMID:17557824
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q3HL75	Human	PMID:17653767
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P9WHT9	Human	PMID:17849409
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P9WIN9	Human	PMID:17849409
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P9WNN1	Human	PMID:17849409
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q8IJN7	Human	PMID:19642995
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P04196	Human	PMID:19712047
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q27727	Human	PMID:21949403
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q44790	Human	PMID:22087329
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q99SU7	Human	PMID:22321644
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75189	Human	PMID:23197176
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75391	Human	PMID:23197176
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75390	Human	PMID:25978044
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75391	Human	PMID:25978044
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75392	Human	PMID:25978044
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75393	Human	PMID:25978044
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q2FZB8	Human	PMID:26627825
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75167	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75358	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75390	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75391	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75392	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P75611	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P78007	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P78031	Human	PMID:26667841
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q8N4S9	Human	PMID:26822058
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P28300:PRO_0000018520	Human	PMID:30082873
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P07996	Human	PMID:6438154
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:P44324	Human	PMID:9092705
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q28640	Human	PMID:9102401
Molecular Function	GO:0005515	protein binding	PLG	IPI	UniProtKB:Q5XD01	Human	PMID:9603964
Molecular Function	GO:0019904	protein domain specific binding	PLG	IPI	UniProtKB:P08169	Human	PMID:20028034
Molecular Function	GO:0019904	protein domain specific binding	PLG	IPI	UniProtKB:P05452	Human	PMID:9786936
Molecular Function	GO:0051087	protein-folding chaperone binding	PLG	IPI	UniProtKB:Q9K0N4	Human	PMID:17307854
Molecular Function	GO:0051087	protein-folding chaperone binding	PLG	IPI	UniProtKB:P9WMJ9	Human	PMID:17849409
Molecular Function	GO:0051087	protein-folding chaperone binding	PLG	IPI	UniProtKB:P9WPE5	Human	PMID:17849409
Molecular Function	GO:0051087	protein-folding chaperone binding	PLG	IPI	UniProtKB:B7GT47	Human	PMID:19574304
Molecular Function	GO:0051087	protein-folding chaperone binding	PLG	IPI	UniProtKB:Q1G1L9	Human	PMID:19574304
Molecular Function	GO:0051087	protein-folding chaperone binding	PLG	IPI	UniProtKB:Q1G1M0	Human	PMID:19574304
Molecular Function	GO:0004252	serine-type endopeptidase activity	PLG	IDA		Human	PMID:14688145
Molecular Function	GO:0004252	serine-type endopeptidase activity	PLG	IDA		Human	PMID:14699093
Molecular Function	GO:0004252	serine-type endopeptidase activity	PLG	IDA		Human	PMID:17307854
Molecular Function	GO:0004252	serine-type endopeptidase activity	PLG	IMP		Human	PMID:18070902
Molecular Function	GO:0004252	serine-type endopeptidase activity	PLG	IMP		Human	PMID:19270100
Molecular Function	GO:0004252	serine-type endopeptidase activity	PLG	IMP		Human	PMID:20727989
Molecular Function	GO:0005102	signaling receptor binding	PLG	IPI	UniProtKB:P08169	Human	PMID:20028034
Cellular Component	GO:0072562	blood microparticle	PLG	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	PLG	IDA		Human	PMID:14699093
Cellular Component	GO:0009986	cell surface	Plg	IDA		Mouse	PMID:17690254
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PLG	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PLG	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Plg	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Plg	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0009897	external side of plasma membrane	PLG	IDA		Human	PMID:14699093
Cellular Component	GO:0070062	extracellular exosome	PLG	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PLG	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	PLG	IDA		Human	PMID:14688145
Cellular Component	GO:0005615	extracellular space	PLG	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	PLG	IDA		Human	PMID:17307854
Cellular Component	GO:0005615	extracellular space	PLG	IDA		Human	PMID:6216475
Cellular Component	GO:0005615	extracellular space	PLG	IDA		Human	PMID:6980881
Cellular Component	GO:0005615	extracellular space	Plg	IDA		Rat	PMID:7964722|RGD:12792993
Cellular Component	GO:0098978	glutamatergic synapse	Plg	IDA		Mouse	PMID:15486301
Cellular Component	GO:0098978	glutamatergic synapse	Plg	IEP		Mouse	PMID:15486301
Cellular Component	GO:0098978	glutamatergic synapse	Plg	IMP		Mouse	PMID:15486301
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Plg	IDA		Rat	PMID:12928439|RGD:1299253
Cellular Component	GO:0005886	plasma membrane	Plg	IDA		Rat	PMID:19386599|RGD:7243112
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Plg	IDA		Mouse	PMID:15486301
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Plg	IEP		Mouse	PMID:15486301
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Plg	IMP		Mouse	PMID:15486301
Cellular Component	GO:0045202	synapse	Plg	IMP		Mouse	MGI:MGI:3615067|PMID:15486301
Biological Process	GO:0051702	biological process involved in interaction with symbiont	PLG	IDA		Human	PMID:12818429
Biological Process	GO:0007596	blood coagulation	PLG	IMP		Human	PMID:1986355
Biological Process	GO:0022617	extracellular matrix disassembly	PLG	IDA		Human	PMID:14699093
Biological Process	GO:0042730	fibrinolysis	PLG	IDA		Human	PMID:14688145
Biological Process	GO:0042730	fibrinolysis	PLG	IDA		Human	PMID:17307854
Biological Process	GO:0042730	fibrinolysis	PLG	IDA		Human	PMID:22025510
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Plg	IMP	MGI:MGI:1857291	Mouse	PMID:12900459
Biological Process	GO:0071674	mononuclear cell migration	Plg	IMP		Mouse	PMID:17690254
Biological Process	GO:0046716	muscle cell cellular homeostasis	Plg	IMP	MGI:MGI:2158761	Mouse	PMID:11929773
Biological Process	GO:0045445	myoblast differentiation	Plg	IMP		Mouse	PMID:11929773
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	PLG	IDA		Human	PMID:14699093
Biological Process	GO:0051918	negative regulation of fibrinolysis	PLG	IDA		Human	PMID:14726399
Biological Process	GO:0051919	positive regulation of fibrinolysis	PLG	IDA		Human	PMID:26667841
Biological Process	GO:0051919	positive regulation of fibrinolysis	PLG	IDA		Human	PMID:6438154
Biological Process	GO:0006508	proteolysis	PLG	IMP		Human	PMID:18070902
Biological Process	GO:0006508	proteolysis	PLG	IMP		Human	PMID:19270100
Biological Process	GO:0006508	proteolysis	PLG	IDA		Human	PMID:9603964
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Plg	IDA		Rat	PMID:12928439|RGD:1299253
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Plg	IDA		Rat	PMID:7864083|RGD:2301095
Biological Process	GO:0042246	tissue regeneration	Plg	IMP	MGI:MGI:2158761	Mouse	PMID:11929773
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Plg	IDA		Mouse	PMID:15486301
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Plg	IMP		Mouse	PMID:15486301
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Plg	IEP		Mouse	PMID:15486301
Biological Process	GO:0060707	trophoblast giant cell differentiation	Plg	IMP	MGI:MGI:1857291	Mouse	PMID:12900459

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern