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Plg Gene Detail
Summary
  • Symbol
    Plg
  • Name
    plasminogen
  • Synonyms
    Pg
  • Feature Type
    protein coding gene
  • IDs
    MGI:97620
    NCBI Gene: 18815
  • Gene Overview
    MyGene.info: PLG
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12378609-12419384 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.50 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97620
 protein coding gene Chr17:12378608-12419385 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023145
 protein coding gene Chr17:10030376-10072452 (+)
A/J MGP_AJ_G0023113
 protein coding gene Chr17:9870978-9912846 (+)
AKR/J MGP_AKRJ_G0023077
 protein coding gene Chr17:9697651-9739788 (+)
BALB/cJ MGP_BALBcJ_G0023113
 protein coding gene Chr17:9644105-9686373 (+)
C3H/HeJ MGP_C3HHeJ_G0022876
 protein coding gene Chr17:9944436-9986466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023556
 protein coding gene Chr17:10419468-10461280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021052
 protein coding gene Chr17:4534642-4576257 (-)
CAST/EiJ MGP_CASTEiJ_G0022390
 protein coding gene Chr17:9998764-10040551 (+)
CBA/J MGP_CBAJ_G0022848
 protein coding gene Chr17:10790590-10834351 (+)
DBA/2J MGP_DBA2J_G0022981
 protein coding gene Chr17:9495643-9537099 (+)
FVB/NJ MGP_FVBNJ_G0022951
 protein coding gene Chr17:9446300-9486716 (+)
LP/J MGP_LPJ_G0023053
 protein coding gene Chr17:9841139-9883612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022970
 protein coding gene Chr17:10417887-10458524 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023582
 protein coding gene Chr17:9957523-10000102 (+)
PWK/PhJ MGP_PWKPhJ_G0022138
 protein coding gene Chr17:9196327-9239119 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021968
 protein coding gene Chr17:9370704-9413507 (+)
WSB/EiJ MGP_WSBEiJ_G0022447
 protein coding gene Chr17:10287081-10327648 (+)



Homology
more
  • Human Ortholog
    PLG, plasminogen
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLG, plasminogen
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5340
    neXtProt AC: NX_P00747
    UniProt: P00747

  • Chr Location
    6q26; chr6:160702193-160754054 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 55452
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLG
  • Protein SuperFamily
    plasmin
  • Gene Tree
    Plg
Human Diseases
more
  • Diseases
    1 with human PLG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 3 alleles in 13 genetic backgrounds
    26 phenotypes from multigenic genotypes
    3 images
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    670
  • Tissues
    19
  • cDNA Data
    158
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18815 NCBI Gene Model | MGI Sequence Detail 40776 C57BL/6J ±  kb
    transcript NM_008877 RefSeq | MGI Sequence Detail 2755 C57BL/6  
    polypeptide P20918 UniProt | EBI | MGI Sequence Detail 812 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 174
      Genomic 10
      cDNA 158
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13360, MGI:2146904
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 128
    • Earliest
      J:47228 Miyata T, et al., Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6132-6
    • Latest
      J:284959 Merino P, et al., Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse. J Biol Chem. 2020 Jan 10;295(2):619-630
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    10/13/2020
    MGI 6.16     		The Jackson Laboratory