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Plg Gene Detail
Summary
  • Symbol
    Plg
  • Name
    plasminogen
  • Synonyms
    Pg
  • Feature Type
    protein coding gene
  • IDs
    MGI:97620
    NCBI Gene: 18815
  • Gene Overview
    MyGene.info: PLG
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:12378609-12419384 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      40776 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.50 cM
  • Mapping Data
    26 experiments
Homology
more
  • Human Ortholog
    PLG, plasminogen
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLG, plasminogen
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5340
    neXtProt AC: NX_P00747
    UniProt: P00747

  • Chr Location
    6q26; chr6:160702193-160754054 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 55452
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLG
  • Protein SuperFamily
    plasmin
  • Gene Tree
    Plg
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 3 alleles in 13 genetic backgrounds
    26 phenotypes from multigenic genotypes
    3 images
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    34
  • Tissues
    15
  • cDNA Data
    157
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18815 NCBI Gene Model | MGI Sequence Detail 40776 C57BL/6J ±  kb
    transcript NM_008877 RefSeq | MGI Sequence Detail 2755 C57BL/6  
    polypeptide P20918 UniProt | EBI | MGI Sequence Detail 812 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      296 from dbSNP Build 142
    • RFLP
      9
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      Genomic 10
      cDNA 157
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13360, MGI:2146904
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 120
    • Earliest
      J:47228 Miyata T, et al., Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6132-6
    • Latest
      J:248070 Tashima Y, et al., Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions. PLoS One. 2017;12(7):e0180981
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory