Plg MGI Mouse Gene Detail - MGI:97620

Symbol

Plg
Name

plasminogen
Synonyms

Pg

Feature Type

protein coding gene
IDs

MGI:97620
NCBI Gene: 18815
Gene Overview

MyGene.info: PLG
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:12378609-12419384 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.50 cM
Mapping Data

26 experiments

SNPs within 2kb

296 from dbSNP Build 142
Strain Annotations

18
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97620	protein coding gene	Chr17:12378609-12419384 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0023145	protein coding gene	Chr17:10030376-10072452 (+)
A/J	MGP_AJ_G0023113	protein coding gene	Chr17:9870978-9912846 (+)
AKR/J	MGP_AKRJ_G0023077	protein coding gene	Chr17:9697651-9739788 (+)
BALB/cJ	MGP_BALBcJ_G0023113	protein coding gene	Chr17:9644105-9686373 (+)
C3H/HeJ	MGP_C3HHeJ_G0022876	protein coding gene	Chr17:9944436-9986466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023556	protein coding gene	Chr17:10419468-10461280 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021052	protein coding gene	Chr17:4534642-4576257 (-)
CAST/EiJ	MGP_CASTEiJ_G0022390	protein coding gene	Chr17:9998764-10040551 (+)
CBA/J	MGP_CBAJ_G0022848	protein coding gene	Chr17:10790590-10834351 (+)
DBA/2J	MGP_DBA2J_G0022981	protein coding gene	Chr17:9495643-9537099 (+)
FVB/NJ	MGP_FVBNJ_G0022951	protein coding gene	Chr17:9446300-9486716 (+)
LP/J	MGP_LPJ_G0023053	protein coding gene	Chr17:9841139-9883612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022970	protein coding gene	Chr17:10417887-10458524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023582	protein coding gene	Chr17:9957523-10000102 (+)
PWK/PhJ	MGP_PWKPhJ_G0022138	protein coding gene	Chr17:9196327-9239119 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021968	protein coding gene	Chr17:9370704-9413507 (+)
WSB/EiJ	MGP_WSBEiJ_G0022447	protein coding gene	Chr17:10287081-10327648 (+)

Human Ortholog

PLG, plasminogen

Vertebrate Orthologs

10

Human Ortholog

PLG, plasminogen
Orthology source: HomoloGene, HGNC
Links

HGNC:9071

NCBI Gene ID: 5340

neXtProt AC: NX_P00747

UniProt: P00747
Chr Location

6q26; chr6:160702193-160754054 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55452
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PLG
Protein SuperFamily

plasmin
Gene Tree

Plg

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Phenotype Summary

64 phenotypes from 3 alleles in 13 genetic backgrounds
26 phenotypes from multigenic genotypes
3 images
120 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.

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All GO Annotations

54
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

34
Tissues

15
cDNA Data

158
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plg

ZFIN plg

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Plg interacts with 57 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS28390.1
UniGene

971

Ensembl

ENSMUSG00000059481 (Evidence)
NCBI Gene

18815

			Length	Strain/Species	Flank
genomic	18815	NCBI Gene Model \| MGI Sequence Detail	40776	C57BL/6J	± kb
transcript	NM_008877	RefSeq \| MGI Sequence Detail	2755	C57BL/6
polypeptide	P20918	UniProt \| EBI \| MGI Sequence Detail	812	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012867 plasminogen

(term hierarchy)
EC

3.4.21.7
InterPro Domains

IPR000001 Kringle

IPR018056 Kringle, conserved site

IPR013806 Kringle-like fold

IPR038178 Kringle superfamily

IPR003609 PAN/Apple domain

IPR001314 Peptidase S1A, chymotrypsin family

IPR023317 Peptidase S1A, plasmin

IPR009003 Peptidase S1, PA clan

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site

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All nucleic 173

Genomic 10

cDNA 158

Primer pair 3

Other 2

Microarray probesets 5

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MGD-MRK-13360, MGI:2146904

Summaries

All 199

Developmental Gene Expression 8

Gene Ontology 13

Phenotypes 120
Earliest

J:47228 Miyata T, et al., Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6132-6
Latest

J:266528 Baker SK, et al., Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9687-E9696

TSS for Plg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142597	Chr17:12378603-12378621 (+)	3 bp
Tssr142598	Chr17:12378629-12378646 (+)	29 bp
Tssr142599	Chr17:12378652-12378665 (+)	50 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13