Plg
Gene Detail

Symbol Name ID

Plg plasminogen MGI:97620

Synonyms

Pg

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr17:12378609-12419384 bp, + strand From NCBI annotation of GRCm38   40776 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55452  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: plasmin
Gene Tree: Plg

Human homologs

Human Homolog		PLG, plasminogen
NCBI Gene ID		5340
neXtProt AC		NX_P00747
Human Chr (Location)		6q26; chr6:160702193-160754054 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human PLG

Alleles and phenotypes

All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.

 
Human Diseases Modeled Using Mouse Plg (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	blood coagulation, extracellular matrix disassembly, ...
Component	blood microparticle, cell surface, ...
Function	apolipoprotein binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (38)    Tissues (17)    Images (15)
Theiler Stages: 1, 2, 3, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	15
RT-PCR	23

cDNA source data(157)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(172) Genomic(10) cDNA(157) Primer pair(3) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000059481 (Evidence)
Entrez Gene	18815 (Evidence)
UniGene	971
DFCI	TC1575267, TC1594503
DoTS	DT.101352252, DT.102542318, DT.536790, DT.94360462
NIA Mouse Gene Index	U017496
EC	3.4.21.7
Consensus CDS Project	CCDS28390.1
International Mouse Knockout Project Status	Plg

Sequences

Length	Strain/Species
genomic	18815	NCBI Gene Model | MGI Sequence Detail	40776	C57BL/6J
transcript	NM_008877	RefSeq | MGI Sequence Detail	2755	C57BL/6
polypeptide	P20918	UniProt | EBI | MGI Sequence Detail	812	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(9) : SNPs within 2kb(299 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003609	Apple-like
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR003014	PAN-1 domain
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR023317	Peptidase S1A, plasmin
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000012867	plasminogen

Graphical View of Protein Domain Structure

References

(Earliest) J:47228 Miyata T, et al., Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6132-6
(Latest) J:208125 Huang M, et al., Lp(a)/apo(a) Modulate MMP-9 Activation and Neutrophil Cytokines in Vivo in Inflammation to Regulate Leukocyte Recruitment. Am J Pathol. 2014 May;184(5):1503-17
All references(172)

Other accession IDs

MGD-MRK-13360, MGI:2146904