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Plg
Gene Detail
 Symbol
Name
ID
Plg
plasminogen
MGI:97620
Synonyms Pg
Feature Type protein coding gene
Genetic Map
Chromosome 17
8.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr17:12378609-12419384 bp, + strand
From NCBI annotation of GRCm38

  40776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55452  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: plasmin
Gene Tree: Plg

Human
homologs
Human Homolog PLG, plasminogen
NCBI Gene ID 5340
neXtProt AC  NX_P00747
Human Chr (Location)  6q26; chr6:160702193-160754054 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLG
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.
 
Human Diseases Modeled Using Mouse Plg (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process blood coagulation, extracellular matrix disassembly, ...
Component blood microparticle, cell surface, ...
Function apolipoprotein binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (38)    Tissues (17)    Images (15)
Theiler Stages: 1, 2, 3, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 15
RT-PCR 23
cDNA source data(157)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(172) Genomic(10) cDNA(157) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000059481 (Evidence)
Entrez Gene18815 (Evidence)
UniGene971
DFCITC1575267, TC1594503
DoTSDT.101352252, DT.102542318, DT.536790, DT.94360462
NIA Mouse Gene IndexU017496
EC3.4.21.7
Consensus CDS ProjectCCDS28390.1
International Mouse Knockout Project StatusPlg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18815 NCBI Gene Model | MGI Sequence Detail 40776 C57BL/6J ±  kb
transcript NM_008877 RefSeq | MGI Sequence Detail 2755 C57BL/6 
polypeptide P20918 UniProt | EBI | MGI Sequence Detail 812 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms RFLP(9) : SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003609 Apple-like
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR003014 PAN-1 domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR023317 Peptidase S1A, plasmin
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000012867 plasminogen
Graphical View of Protein Domain Structure
References (Earliest) J:47228 Miyata T, et al., Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6132-6
(Latest) J:208125 Huang M, et al., Lp(a)/apo(a) Modulate MMP-9 Activation and Neutrophil Cytokines in Vivo in Inflammation to Regulate Leukocyte Recruitment. Am J Pathol. 2014 May;184(5):1503-17
All references(172)
Other
accession IDs
MGD-MRK-13360, MGI:2146904

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory