Plg MGI Mouse Gene Detail - MGI:97620

Symbol

Plg
Name

plasminogen
Synonyms

Pg

Feature Type

protein coding gene
IDs

MGI:97620
NCBI Gene: 18815
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr17:12597496-12638271 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.50 cM
Mapping Data

26 experiments

SNPs within 2kb

292 from dbSNP Build 142
Strain Annotations

18
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97620	protein coding gene	Chr17:12597495-12638272 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023145	protein coding gene	Chr17:10030376-10072452 (+)
A/J	MGP_AJ_G0023113	protein coding gene	Chr17:9870978-9912846 (+)
AKR/J	MGP_AKRJ_G0023077	protein coding gene	Chr17:9697651-9739788 (+)
BALB/cJ	MGP_BALBcJ_G0023113	protein coding gene	Chr17:9644105-9686373 (+)
C3H/HeJ	MGP_C3HHeJ_G0022876	protein coding gene	Chr17:9944436-9986466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023556	protein coding gene	Chr17:10419468-10461280 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021052	protein coding gene	Chr17:4534642-4576257 (-)
CAST/EiJ	MGP_CASTEiJ_G0022390	protein coding gene	Chr17:9998764-10040551 (+)
CBA/J	MGP_CBAJ_G0022848	protein coding gene	Chr17:10790590-10834351 (+)
DBA/2J	MGP_DBA2J_G0022981	protein coding gene	Chr17:9495643-9537099 (+)
FVB/NJ	MGP_FVBNJ_G0022951	protein coding gene	Chr17:9446300-9486716 (+)
LP/J	MGP_LPJ_G0023053	protein coding gene	Chr17:9841139-9883612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022970	protein coding gene	Chr17:10417887-10458524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023582	protein coding gene	Chr17:9957523-10000102 (+)
PWK/PhJ	MGP_PWKPhJ_G0022138	protein coding gene	Chr17:9196327-9239119 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021968	protein coding gene	Chr17:9370704-9413507 (+)
WSB/EiJ	MGP_WSBEiJ_G0022447	protein coding gene	Chr17:10287081-10327648 (+)

Human Ortholog

PLG, plasminogen

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLG, plasminogen
Synonyms

HAE4
Links

HGNC:9071

NCBI Gene ID: 5340

neXtProt AC: NX_P00747

UniProt: P00747
Chr Location

6q26; chr6:160702193-160754054 (+) GRCh38.p7

Alliance of Genome Resources

Plg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLG
Protein SuperFamily

Plasmin
Gene Tree

Plg

Diseases

5 with human PLG associations

				Human Disease	Mouse Models
				conjunctivitis IDs conjunctivitis DOID:6195 ICD10CM:H10 ICD9CM:372.30 MESH:D003231 NCI:C34504 UMLS_CUI:C0009763
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				hereditary angioedema IDs hereditary angioedema DOID:14735 MESH:D054179 NCI:C84758 UMLS_CUI:C0019243
				plasminogen deficiency type I IDs plasminogen deficiency type I DOID:0111592 ICD10CM:E88.02 MESH:C566897 MESH:C580017 OMIM:217090 ORDO:722 UMLS_CUI:C0398621 UMLS_CUI:C1968804
				thrombophilia IDs thrombophilia DOID:2452 ICD10CM:D68.59 MESH:D019851 NCI:C84479 OMIM:PS188050 UMLS_CUI:C0398623

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

65 phenotypes from 3 alleles in 13 genetic backgrounds
26 phenotypes from multigenic genotypes
3 images
133 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.

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All GO Annotations

58
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

19
cDNA Data

158
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plg

ZFIN plg

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Plg interacts with 57 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS28390.1

Ensembl

ENSMUSG00000059481 (Evidence)
NCBI Gene

18815

			Length	Strain/Species	Flank
genomic	18815	NCBI Gene Model \| MGI Sequence Detail	40776	C57BL/6J	± kb
transcript	NM_008877	RefSeq \| MGI Sequence Detail	2755	C57BL/6
polypeptide	P20918	UniProt \| EBI \| MGI Sequence Detail	812	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012867 plasminogen

(term hierarchy)
EC

3.4.21.7
InterPro Domains

IPR000001 Kringle

IPR018056 Kringle, conserved site

IPR013806 Kringle-like fold

IPR038178 Kringle superfamily

IPR003609 PAN/Apple domain

IPR001314 Peptidase S1A, chymotrypsin family

IPR023317 Peptidase S1A, plasmin

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site

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All nucleic 174

Genomic 10

cDNA 158

Primer pair 4

Other 2

Microarray probesets 5

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MGD-MRK-13360, MGI:2146904

Summaries

All 218

Developmental Gene Expression 9

Gene Ontology 12

Phenotypes 133
Earliest

J:47228 Miyata T, et al., Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A. 1982 Oct;79(20):6132-6
Latest

J:315673 Henderson MW, et al., Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure. Blood. 2021 Jul 22;138(3):259-272

TSS for Plg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142597	Chr17:12597490-12597508 (+)	3 bp
Tssr142598	Chr17:12597516-12597533 (+)	29 bp
Tssr142599	Chr17:12597539-12597552 (+)	50 bp
Tssr142600	Chr17:12601004-12601016 (+)	3,514 bp
Tssr142601	Chr17:12601713-12601731 (+)	4,226 bp
Tssr142602	Chr17:12603277-12603291 (+)	5,788 bp
Tssr142603	Chr17:12609128-12609139 (+)	11,638 bp
Tssr142604	Chr17:12609174-12609192 (+)	11,687 bp
Tssr142605	Chr17:12610666-12610678 (+)	13,176 bp
Tssr142606	Chr17:12610705-12610716 (+)	13,215 bp
Tssr142607	Chr17:12612051-12612061 (+)	14,560 bp
Tssr142608	Chr17:12614504-12614524 (+)	17,018 bp
Tssr142609	Chr17:12615488-12615499 (+)	17,998 bp
Tssr142610	Chr17:12615518-12615527 (+)	18,027 bp
Tssr142611	Chr17:12621978-12621989 (+)	24,488 bp
Tssr142612	Chr17:12622966-12622977 (+)	25,476 bp
Tssr142613	Chr17:12627941-12627960 (+)	30,455 bp
Tssr142614	Chr17:12629785-12629822 (+)	32,308 bp
Tssr142615	Chr17:12637918-12637933 (+)	40,430 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/03/2022 MGI 6.21