Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pcsk1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PCSK1
- Mouse genes Pcsk1
- Rat genes Pcsk1
- Zfish genes pcsk1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pcsk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	Pcsk1	IDA		Mouse	MGI:MGI:3807770\|PMID:9242664
Molecular Function	GO:0004175	endopeptidase activity	Pcsk1	IDA		Rat	PMID:10087454\|RGD:2308913
Molecular Function	GO:0004175	endopeptidase activity	Pcsk1	IMP		Rat	PMID:9556596\|RGD:2308914
Molecular Function	GO:0042802	identical protein binding	Pcsk1	IPI	UniProtKB:P63239	Mouse	MGI:MGI:6092976\|PMID:19376969
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk1	IDA		Mouse	MGI:MGI:3773775\|PMID:8262946
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk1	IMP	MGI:MGI:2384741	Mouse	PMID:12136131
Cellular Component	GO:0043679	axon terminus	Pcsk1	IDA		Rat	PMID:10906712\|RGD:2308907
Cellular Component	GO:0030425	dendrite	Pcsk1	IDA		Rat	PMID:10906712\|RGD:2308907
Cellular Component	GO:0005615	extracellular space	PCSK1	IDA		Human	PMID:8397508
Cellular Component	GO:0005615	extracellular space	Pcsk1	IDA		Mouse	MGI:MGI:3793923\|PMID:8397508
Cellular Component	GO:0005615	extracellular space	Pcsk1	IDA		Rat	PMID:9389490\|RGD:2308916
Cellular Component	GO:0043005	neuron projection	Pcsk1	IDA		Rat	PMID:17543468\|RGD:2308893
Cellular Component	GO:0043025	neuronal cell body	Pcsk1	IDA		Rat	PMID:10906712\|RGD:2308907
Cellular Component	GO:0043025	neuronal cell body	Pcsk1	IDA		Rat	PMID:17543468\|RGD:2308893
Cellular Component	GO:0043204	perikaryon	Pcsk1	IDA		Rat	PMID:17543468\|RGD:2308893
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pcsk1	IDA		Rat	PMID:9389490\|RGD:2308916
Cellular Component	GO:0005791	rough endoplasmic reticulum	Pcsk1	IDA		Rat	PMID:9405499\|RGD:2308915
Cellular Component	GO:0030141	secretory granule	Pcsk1	IDA		Mouse	PMID:12136131
Cellular Component	GO:0030141	secretory granule	Pcsk1	IDA		Rat	PMID:7822759\|RGD:2308908
Cellular Component	GO:0030141	secretory granule	Pcsk1	IDA		Rat	PMID:10806118\|RGD:1625123
Cellular Component	GO:0005802	trans-Golgi network	Pcsk1	IDA		Rat	PMID:10906712\|RGD:2308907
Biological Process	GO:0030070	insulin processing	Pcsk1	IMP	MGI:MGI:2384741	Mouse	PMID:12136131
Biological Process	GO:0022008	neurogenesis	Pcsk1	IEP		Rat	PMID:18781386\|RGD:2308890
Biological Process	GO:0031016	pancreas development	Pcsk1	IEP		Rat	PMID:17221210\|RGD:2308896
Biological Process	GO:0043043	peptide biosynthetic process	Pcsk1	IDA		Mouse	MGI:MGI:3773775\|PMID:8262946
Biological Process	GO:0016486	peptide hormone processing	Pcsk1	IDA		Mouse	MGI:MGI:3807770\|PMID:9242664
Biological Process	GO:0016486	peptide hormone processing	Pcsk1	IDA		Mouse	MGI:MGI:3773775\|PMID:8262946
Biological Process	GO:0016486	peptide hormone processing	Pcsk1	IDA		Rat	PMID:10087454\|RGD:2308913
Biological Process	GO:0016486	peptide hormone processing	Pcsk1	IMP		Rat	PMID:16497799\|RGD:1601276
Biological Process	GO:0021983	pituitary gland development	Pcsk1	IEP		Rat	PMID:15208361\|RGD:2308902
Biological Process	GO:0050714	positive regulation of protein secretion	Pcsk1	IMP		Rat	PMID:12721373\|RGD:734486
Biological Process	GO:0050714	positive regulation of protein secretion	Pcsk1	IDA		Rat	PMID:9389490\|RGD:2308916
Biological Process	GO:0016540	protein autoprocessing	Pcsk1	IMP		Rat	PMID:9556596\|RGD:2308914
Biological Process	GO:0016485	protein processing	Pcsk1	IDA		Mouse	MGI:MGI:3807770\|PMID:9242664
Biological Process	GO:0016485	protein processing	Pcsk1	IMP		Rat	PMID:16497799\|RGD:1601276
Biological Process	GO:0048678	response to axon injury	Pcsk1	IEP		Rat	PMID:18585435\|RGD:2308892
Biological Process	GO:0051592	response to calcium ion	Pcsk1	IEP		Rat	PMID:9556596\|RGD:2308914
Biological Process	GO:0010157	response to chlorate	Pcsk1	IEP		Rat	PMID:17221210\|RGD:2308896
Biological Process	GO:0070542	response to fatty acid	Pcsk1	IEP		Rat	PMID:18781386\|RGD:2308890
Biological Process	GO:0051384	response to glucocorticoid	Pcsk1	IEP		Rat	PMID:11751617\|RGD:70594
Biological Process	GO:0009749	response to glucose	Pcsk1	IEP		Rat	PMID:17283238\|RGD:2308894
Biological Process	GO:0010035	response to inorganic substance	Pcsk1	IEP		Rat	PMID:12501973\|RGD:2308903
Biological Process	GO:0070555	response to interleukin-1	Pcsk1	IEP		Rat	PMID:17283238\|RGD:2308894
Biological Process	GO:0032496	response to lipopolysaccharide	Pcsk1	IEP		Rat	PMID:10630414\|RGD:2308911
Biological Process	GO:0043278	response to morphine	Pcsk1	IEP		Rat	PMID:18771713\|RGD:2308891
Biological Process	GO:0031667	response to nutrient levels	Pcsk1	IEP		Rat	PMID:17584972\|RGD:2308895
Biological Process	GO:0014070	response to organic cyclic compound	Pcsk1	IEP		Rat	PMID:10971617\|RGD:2308906
Biological Process	GO:0043434	response to peptide hormone	Pcsk1	IEP		Rat	PMID:17584972\|RGD:2308895
Biological Process	GO:0009410	response to xenobiotic stimulus	Pcsk1	IEP		Rat	PMID:10971617\|RGD:2308906

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.