Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PAPPA2
  • Mouse genes Pappa2
  • Rat genes Pappa2
  • Zfish genes pappa2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pappa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004222	metalloendopeptidase activity	PAPPA2	EXP		Human	PMID:11513734
Molecular Function	GO:0008237	metallopeptidase activity	PAPPA2	IDA		Human	PMID:11264294
Molecular Function	GO:0008233	peptidase activity	pappa2	IDA		Zfish	PMID:25236600
Cellular Component	GO:0016324	apical plasma membrane	Pappa2	IDA		Rat	PMID:26534937|RGD:11553579
Cellular Component	GO:0005829	cytosol	Pappa2	IDA		Rat	PMID:26534937|RGD:11553579
Cellular Component	GO:0070062	extracellular exosome	PAPPA2	HDA		Human	PMID:23533145
Biological Process	GO:0001525	angiogenesis	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-1	Zfish	PMID:25236600
Biological Process	GO:0001525	angiogenesis	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-2	Zfish	PMID:25236600
Biological Process	GO:0001525	angiogenesis	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-3	Zfish	PMID:25236600
Biological Process	GO:0060349	bone morphogenesis	Pappa2	IMP	MGI:MGI:5504500	Mouse	PMID:23457539
Biological Process	GO:0051216	cartilage development	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-2	Zfish	PMID:25236600
Biological Process	GO:0051216	cartilage development	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-3	Zfish	PMID:25236600
Biological Process	GO:0051216	cartilage development	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-1	Zfish	PMID:25236600
Biological Process	GO:0030903	notochord development	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-3	Zfish	PMID:25236600
Biological Process	GO:0030903	notochord development	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-2	Zfish	PMID:25236600
Biological Process	GO:0030903	notochord development	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-1	Zfish	PMID:25236600
Biological Process	GO:0006508	proteolysis	PAPPA2	IDA		Human	PMID:11264294
Biological Process	GO:0008593	regulation of Notch signaling pathway	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-1	Zfish	PMID:25236600
Biological Process	GO:0008593	regulation of Notch signaling pathway	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-2	Zfish	PMID:25236600
Biological Process	GO:0008593	regulation of Notch signaling pathway	pappa2	IMP	ZFIN:ZDB-MRPHLNO-150224-3	Zfish	PMID:25236600
Biological Process	GO:0009651	response to salt stress	Pappa2	IEP		Rat	PMID:26534937|RGD:11553579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern