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Pappa2
Gene Detail
Symbol

Name
ID
Pappa2
pappalysin 2
MGI:3051647
Synonyms
PAPP-A2, Pappe, PLAC3, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E
Feature Type
protein coding gene
Genetic Map
Chromosome 1
68.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:158711727-158980490 bp, - strand
From VEGA annotation of GRCm38

  268764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pappa2

Human
homologs
Human Homolog PAPPA2, pappalysin 2
NCBI Gene ID 60676
neXtProt AC  NX_Q9BXP8
Human Synonyms  PAPP-A2, PAPPE, PAPP-E, PLAC3
Human Chr (Location)  1q23-q25; chr1:176463171-176845601 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males.
 
Interactions
Pappa2 interacts with 379 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process bone morphogenesis, proteolysis
Component extracellular vesicular exosome
Function metalloendopeptidase activity, metallopeptidase activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (202)    Tissues (129)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 160
RT-PCR 42
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) cDNA(36) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029804 (Evidence)
Ensembl Gene ModelENSMUSG00000073530 (Evidence)
Entrez Gene23850 (Evidence)
UniGene458621
DFCITC1636572, TC1659344, TC1718147
DoTSDT.101280431, DT.523677
NIA Mouse Gene IndexU021939
Consensus CDS ProjectCCDS48409.1
International Mouse Knockout Project StatusPappa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029804 VEGA Gene Model | MGI Sequence Detail 268764 C57BL/6J ±  kb
transcript OTTMUST00000074130 VEGA | MGI Sequence Detail 9518 Not Applicable 
polypeptide OTTMUSP00000038478 VEGA | MGI Sequence Detail 1789 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(2266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR003961 Fibronectin, type III
InterPro IPR011936 Myxococcus cysteine-rich repeat
InterPro IPR000800 Notch domain
InterPro IPR026918 Pappalysin-2
InterPro IPR008754 Peptidase M43, pregnancy-associated plasma-A
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000012271 pappalysin-2
References
(Earliest) J:6660 Rougeon F, et al., Molecular cloning of a mouse submaxillary gland renin cDNA fragment. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6367-71
(Latest) J:199327 Christians JK, et al., Pregnancy associated plasma protein A2 (PAPP-A2) affects bone size and shape and contributes to natural variation in postnatal growth in mice. PLoS One. 2013;8(2):e56260
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory