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Pappa2 Gene Detail
Summary
  • Symbol
    Pappa2
  • Name
    pappalysin 2
  • Synonyms
    PAPP-A2, Pappe, PLAC3, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E
  • Feature Type
    protein coding gene
  • IDs
    MGI:3051647
    NCBI Gene: 23850
  • Gene Overview
    MyGene.info: PAPPA2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:158711727-158980490 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 68.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2261 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3051647
protein coding gene Chr1:158711727-158980527 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016636
protein coding gene Chr1:163816607-164104591 (-)
A/J MGP_AJ_G0016617
protein coding gene Chr1:157177472-157442487 (-)
AKR/J MGP_AKRJ_G0016583
protein coding gene Chr1:161983954-162264096 (-)
BALB/cJ MGP_BALBcJ_G0016578
protein coding gene Chr1:157701872-157963469 (-)
C3H/HeJ MGP_C3HHeJ_G0016402
protein coding gene Chr1:162134657-162416173 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017039
protein coding gene Chr1:169418090-169713019 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014748
protein coding gene Chr1:149343148-149605194 (-)
CAST/EiJ MGP_CASTEiJ_G0015982
protein coding gene Chr1:161714794-162006884 (-)
CBA/J MGP_CBAJ_G0016377
protein coding gene Chr1:175392712-175695536 (-)
DBA/2J MGP_DBA2J_G0016483
protein coding gene Chr1:156130272-156393525 (-)
FVB/NJ MGP_FVBNJ_G0016481
protein coding gene Chr1:154578471-154857210 (-)
LP/J MGP_LPJ_G0016554
protein coding gene Chr1:164916307-165205070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016506
protein coding gene Chr1:182942269-183238776 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017075
protein coding gene Chr1:161829037-162118400 (-)
PWK/PhJ MGP_PWKPhJ_G0015768
protein coding gene Chr1:155259386-155530362 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016044
protein coding gene Chr1:161944909-162232524 (-)



Homology
more
  • Human Ortholog
    PAPPA2, pappalysin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAPPA2, pappalysin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAPP-A2, PAPPE, PAPP-E, PLAC3
  • Links
    NCBI Gene ID: 60676
    neXtProt AC: NX_Q9BXP8
    UniProt: Q9BXP8

  • Chr Location
    1q25.2; chr1:176463159-176845601 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10661
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PAPPA2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073530 Ensembl Gene Model | MGI Sequence Detail 268764 C57BL/6J ±  kb
    transcript ENSMUST00000159861 Ensembl | MGI Sequence Detail 9518 Not Applicable  
    polypeptide ENSMUSP00000124022 Ensembl | MGI Sequence Detail 1789 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 37
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:6660 Rougeon F, et al., Molecular cloning of a mouse submaxillary gland renin cDNA fragment. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6367-71
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory