Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR5A1
  • Mouse genes Nr5a1
  • Rat genes Nr5a1
  • Zfish genes nr5a1a,nr5a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr5a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nr5a1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0003682	chromatin binding	Nr5a1	IDA		Mouse	PMID:16109736
Molecular Function	GO:0003677	DNA binding	NR5A1	IDA		Human	PMID:10567391
Molecular Function	GO:0003677	DNA binding	nr5a1a	IDA		Zfish	PMID:14517294
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr5a1	IMP		Rat	PMID:12697699|RGD:1624302
Molecular Function	GO:0003700	DNA-binding transcription factor activity	nr5a1a	IDA		Zfish	PMID:14517294
Molecular Function	GO:0003700	DNA-binding transcription factor activity	nr5a1a	IDA		Zfish	PMID:12668625
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NR5A1	IDA		Human	PMID:21412441
Molecular Function	GO:0003690	double-stranded DNA binding	Nr5a1	IDA		Rat	PMID:12697699|RGD:1624302
Molecular Function	GO:0019899	enzyme binding	NR5A1	IPI	UniProtKB:P52824	Human	PMID:17664281
Molecular Function	GO:0019899	enzyme binding	NR5A1	IPI	UniProtKB:Q13574	Human	PMID:17664281
Molecular Function	GO:0004879	nuclear receptor activity	NR5A1	IDA		Human	PMID:23610160
Molecular Function	GO:0004879	nuclear receptor activity	NR5A1	IDA		Human	PMID:8205615
Molecular Function	GO:0005543	phospholipid binding	NR5A1	IDA		Human	PMID:17664281
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:O60869	Human	PMID:10567391
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P51843	Human	PMID:16709599
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:Q92830	Human	PMID:17664281
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P43694	Human	PMID:21220346
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:Q13510	Human	PMID:22927646
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:Q13510-2	Human	PMID:22927646
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P36956	Human	PMID:23610160
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:O43639	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P51843	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P51843	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P40937	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P51843	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:P61024	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:Q53TS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR5A1	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nr5a1	IPI	PR:P23708	Mouse	PMID:12730328
Molecular Function	GO:0005515	protein binding	Nr5a1	IPI	PR:Q04886	Mouse	PMID:12732652
Molecular Function	GO:0005515	protein binding	Nr5a1	IPI	PR:Q99ME7	Mouse	PMID:12651892
Molecular Function	GO:0005515	protein binding	Nr5a1	IPI	PR:Q04887	Mouse	PMID:12732652
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a1	IDA		Mouse	PMID:14726490
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a1	IDA		Mouse	PMID:15590666
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a1	IDA		Mouse	PMID:12730328
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NR5A1	IDA		Human	PMID:23610160
Molecular Function	GO:0043565	sequence-specific DNA binding	NR5A1	IDA		Human	PMID:27378692
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr5a1	IDA		Rat	PMID:12697699|RGD:1624302
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR5A1	IDA		Human	PMID:28473536
Molecular Function	GO:0001221	transcription coregulator binding	NR5A1	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Cellular Component	GO:0005829	cytosol	NR5A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NR5A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NR5A1	IDA		Human	PMID:10567391
Cellular Component	GO:0005634	nucleus	NR5A1	IDA		Human	PMID:10848616
Cellular Component	GO:0005634	nucleus	NR5A1	IDA		Human	PMID:17664281
Cellular Component	GO:0005634	nucleus	Nr5a1	IDA		Mouse	MGI:MGI:3694160|PMID:10848616
Cellular Component	GO:0005634	nucleus	Nr5a1	IDA		Rat	PMID:12697699|RGD:1624302
Cellular Component	GO:0005634	nucleus	Nr5a1	IDA		Rat	PMID:12865342|RGD:1598968
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Nr5a1	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Biological Process	GO:0030325	adrenal gland development	Nr5a1	IMP	MGI:MGI:1857391	Mouse	PMID:16176945
Biological Process	GO:0030325	adrenal gland development	Nr5a1	IMP	MGI:MGI:5292676	Mouse	PMID:21820362
Biological Process	GO:0030325	adrenal gland development	Nr5a1	IGI	MGI:MGI:1352460	Mouse	PMID:11796523
Biological Process	GO:0030325	adrenal gland development	Nr5a1	IMP		Mouse	PMID:11796523
Biological Process	GO:0030325	adrenal gland development	nr5a1a	IMP	ZFIN:ZDB-MRPHLNO-050225-4	Zfish	PMID:12668625
Biological Process	GO:0030325	adrenal gland development	nr5a1a	IMP		Zfish	PMID:12885566
Biological Process	GO:0097720	calcineurin-mediated signaling	Nr5a1	IMP		Rat	PMID:25057110|RGD:12904895
Biological Process	GO:0006351	DNA-templated transcription	nr5a1a	IDA		Zfish	PMID:12668625
Biological Process	GO:0031018	endocrine pancreas development	nr5a1a	IMP	ZFIN:ZDB-MRPHLNO-070130-5	Zfish	PMID:20965759
Biological Process	GO:0008585	female gonad development	NR5A1	IMP		Human	PMID:27378692
Biological Process	GO:0008585	female gonad development	Nr5a1	IEP		Rat	PMID:12865342|RGD:1598968
Biological Process	GO:0042445	hormone metabolic process	Nr5a1	IMP	MGI:MGI:5292676	Mouse	PMID:21820362
Biological Process	GO:0009755	hormone-mediated signaling pathway	Nr5a1	IDA		Rat	PMID:25057110|RGD:12904895
Biological Process	GO:0021854	hypothalamus development	nr5a1a	IMP	ZFIN:ZDB-MRPHLNO-050225-4	Zfish	PMID:12668625
Biological Process	GO:0033327	Leydig cell differentiation	Nr5a1	IGI	MGI:MGI:1352460	Mouse	PMID:15829514
Biological Process	GO:0001553	luteinization	Nr5a1	IMP	MGI:MGI:2179995,MGI:MGI:2180013	Mouse	PMID:15118069
Biological Process	GO:0051457	maintenance of protein location in nucleus	Nr5a1	IDA		Mouse	PMID:12610109
Biological Process	GO:0008584	male gonad development	NR5A1	IMP		Human	PMID:10369247
Biological Process	GO:0008584	male gonad development	NR5A1	IMP		Human	PMID:27378692
Biological Process	GO:0008584	male gonad development	Nr5a1	IMP	MGI:MGI:5292676	Mouse	PMID:21820362
Biological Process	GO:0008584	male gonad development	Nr5a1	IGI	MGI:MGI:1306784	Mouse	PMID:19457926
Biological Process	GO:0008584	male gonad development	Nr5a1	IMP	MGI:MGI:2179995,MGI:MGI:2180013	Mouse	PMID:15118069
Biological Process	GO:0030238	male sex determination	NR5A1	IMP		Human	PMID:10369247
Biological Process	GO:2000195	negative regulation of female gonad development	Nr5a1	IMP		Mouse	MGI:MGI:3839158|PMID:19301398
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr5a1	IMP		Mouse	MGI:MGI:3839158|PMID:19301398
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr5a1	IDA		Mouse	PMID:12730328
Biological Process	GO:0010628	positive regulation of gene expression	NR5A1	IMP		Human	PMID:23610160
Biological Process	GO:0010628	positive regulation of gene expression	NR5A1	IDA		Human	PMID:27378692
Biological Process	GO:2000020	positive regulation of male gonad development	NR5A1	IDA		Human	PMID:21412441
Biological Process	GO:2000020	positive regulation of male gonad development	Nr5a1	IMP		Mouse	MGI:MGI:3839158|PMID:19301398
Biological Process	GO:2000020	positive regulation of male gonad development	Nr5a1	IMP		Rat	PMID:16467257|RGD:12904919
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR5A1	IMP		Human	PMID:17664281
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR5A1	IGI	UniProtKB:P36956	Human	PMID:23610160
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a1	IGI	UniProtKB:P45448	Mouse	MGI:MGI:5644022|PMID:19389484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a1	IDA		Mouse	PMID:12732652
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a1	IMP		Mouse	PMID:21757499
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a1	IDA		Mouse	PMID:15590666
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a1	IDA		Mouse	PMID:10446902
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a1	IDA		Mouse	PMID:21757499
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	nr5a1a	IDA		Zfish	PMID:12668625
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nr5a1	IDA		Mouse	PMID:12651892
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nr5a1	IDA		Mouse	PMID:12861022
Biological Process	GO:0022414	reproductive process	Nr5a1	IMP	MGI:MGI:5292676	Mouse	PMID:21820362
Biological Process	GO:0097210	response to gonadotropin-releasing hormone	Nr5a1	IEP		Rat	PMID:17344471|RGD:12910563
Biological Process	GO:0060008	Sertoli cell differentiation	Nr5a1	IGI	MGI:MGI:1352460	Mouse	PMID:15829514
Biological Process	GO:0007530	sex determination	NR5A1	IMP		Human	PMID:24405868
Biological Process	GO:0007530	sex determination	NR5A1	IMP		Human	PMID:27378692
Biological Process	GO:0007530	sex determination	NR5A1	IMP		Human	PMID:27490115
Biological Process	GO:0007530	sex determination	NR5A1	IMP		Human	PMID:27610946
Biological Process	GO:0007530	sex determination	NR5A1	IMP		Human	PMID:27855412
Biological Process	GO:0009888	tissue development	Nr5a1	IMP	MGI:MGI:1857391	Mouse	PMID:16176945
Biological Process	GO:0006366	transcription by RNA polymerase II	Nr5a1	IMP		Rat	PMID:12697699|RGD:1624302

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern