About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
Synonym: ligand-dependent nuclear receptor activity
Synonym: ligand-dependent transcription factor activity
Synonym: nuclear hormone receptor
Synonym: nuclear receptor activity
GO id:GO:0004879
Definition:Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
CommentsGO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-anucleic acid binding transcription factor activity
                        is-asequence-specific DNA binding transcription factor activity
                                is-adirect ligand regulated sequence-specific DNA binding transcription factor activity
                                        is-aligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [GO:0004879] (43 genes, 61 annotations)
                                                is-aandrogen receptor activity
                                                is-acalcitriol receptor activity
                                                is-aecdysteroid hormone receptor activity
                                                is-aestrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
                                                is-aglucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
                                                is-ajuvenile hormone receptor activity
                                                is-amineralocorticoid receptor activity
                                                is-aretinoic acid receptor activity +
                                                is-athyroid hormone receptor activity


Gene_Ontology
        is-amolecular_function
                is-anucleic acid binding transcription factor activity
                        is-asequence-specific DNA binding transcription factor activity
                                is-asequence-specific DNA binding RNA polymerase II transcription factor activity
                                        is-aligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [GO:0004879] (43 genes, 61 annotations)
                                                is-aandrogen receptor activity
                                                is-acalcitriol receptor activity
                                                is-aecdysteroid hormone receptor activity
                                                is-aestrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
                                                is-aglucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
                                                is-ajuvenile hormone receptor activity
                                                is-amineralocorticoid receptor activity
                                                is-aretinoic acid receptor activity +
                                                is-athyroid hormone receptor activity
                                        is-ametal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity +
                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity +
                                        is-aRNA polymerase II core promoter sequence-specific DNA binding transcription factor activity +
                                        is-aRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity +
                                        is-aRNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription +
                                        is-aRNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory