About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Synonym: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
Synonym: ligand-dependent nuclear receptor activity
Synonym: ligand-dependent transcription factor activity
Synonym: nuclear hormone receptor
Synonym: nuclear receptor activity
GO id:GO:0004879
Definition:Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
CommentsGO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-amolecular_function
                is-anucleic acid binding transcription factor activity
                        is-atranscription factor activity, sequence-specific DNA binding
                                is-aRNA polymerase II transcription factor activity, sequence-specific DNA binding
                                        is-aRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879] (43 genes, 63 annotations)
                                                is-aandrogen receptor activity
                                                is-acalcitriol receptor activity
                                                is-aecdysteroid hormone receptor activity
                                                is-ajuvenile hormone receptor activity
                                                is-amineralocorticoid receptor activity
                                                is-aretinoic acid receptor activity +
                                                is-aRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
                                                is-aRNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding
                                                is-athyroid hormone receptor activity
                                        is-aRNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding +
                                        is-atranscription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding +
                                        is-atranscription factor activity, RNA polymerase II core promoter sequence-specific +
                                        is-atranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding +
                                        is-atranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding +
                                        is-atranscriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding +


obsolete Gene_Ontology
        is-amolecular_function
                is-anucleic acid binding transcription factor activity
                        is-atranscription factor activity, sequence-specific DNA binding
                                is-atranscription factor activity, direct ligand regulated sequence-specific DNA binding
                                        is-aRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879] (43 genes, 63 annotations)
                                                is-aandrogen receptor activity
                                                is-acalcitriol receptor activity
                                                is-aecdysteroid hormone receptor activity
                                                is-ajuvenile hormone receptor activity
                                                is-amineralocorticoid receptor activity
                                                is-aretinoic acid receptor activity +
                                                is-aRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
                                                is-aRNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding
                                                is-athyroid hormone receptor activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory