Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Msx2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MSX2
- Mouse genes Msx2
- Rat genes Msx2
- Zfish genes msx2a,msx2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Msx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Msx2	IDA		Mouse	PMID:9265625
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Msx2	IDA		Mouse	MGI:MGI:5487530\|PMID:20843790
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Msx2	IDA		Rat	PMID:7877617\|RGD:5132614
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Msx2	IMP		Mouse	MGI:MGI:80319\|PMID:8861098
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Msx2	IDA		Mouse	MGI:MGI:80319\|PMID:8861098
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P12956	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P13010	Human	PMID:12145306
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:O15197-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:O75593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:O95833	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P09086-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P23769	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P28069	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P28482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P31274	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P35711-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P78337	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q01974	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q14119	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q15911-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q68D86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q6ZRY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q8NDC0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q8NEK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q8WU79	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q96HR8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q96K80	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q96PN8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q96PV6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q9BQY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q9BYJ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q9H0E2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q9NQB0-10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q9NZ81	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MSX2	IPI	UniProtKB:Q86WV8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Msx2	IPI	UniProtKB:P25233\|UniProtKB:Q9QYH6	Mouse	MGI:MGI:3828407\|PMID:15272023
Molecular Function	GO:0005515	protein binding	Msx2	IPI	UniProtKB:Q9QYH6	Mouse	MGI:MGI:2181265\|PMID:11959851
Molecular Function	GO:0005515	protein binding	Msx2	IPI	UniProtKB:Q9QYH6	Mouse	MGI:MGI:1930091\|PMID:11084035
Molecular Function	GO:0005515	protein binding	Msx2	IPI	PR:Q62504	Mouse	PMID:10451362
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Msx2	IDA		Rat	PMID:7877617\|RGD:5132614
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Msx2	IMP		Mouse	MGI:MGI:80319\|PMID:8861098
Molecular Function	GO:0043565	sequence-specific DNA binding	MSX2	IDA		Human	PMID:9073066
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	MSX2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Msx2	IDA		Mouse	MGI:MGI:3522068\|PMID:15383550
Molecular Function	GO:0008134	transcription factor binding	Msx2	IPI	PR:Q3THK3	Mouse	PMID:9265625
Molecular Function	GO:0008134	transcription factor binding	Msx2	IDA		Mouse	PMID:9265625
Cellular Component	GO:0005829	cytosol	MSX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	MSX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005667	transcription regulator complex	Msx2	IPI	UniProtKB:Q5SSP7	Mouse	PMID:18285513
Cellular Component	GO:0005667	transcription regulator complex	Msx2	IPI	PR:P70326	Mouse	PMID:18285513
Cellular Component	GO:0005667	transcription regulator complex	Msx2	IPI	UniProtKB:P70324	Mouse	PMID:18285513
Biological Process	GO:0090427	activation of meiosis	Msx2	IPI	MGI:MGI:97168	Mouse	PMID:22071108
Biological Process	GO:0042640	anagen	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:11744114
Biological Process	GO:0009952	anterior/posterior pattern specification	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:21465616
Biological Process	GO:0030509	BMP signaling pathway	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:18667074
Biological Process	GO:0030509	BMP signaling pathway	Msx2	IDA		Mouse	PMID:18590716
Biological Process	GO:0030509	BMP signaling pathway	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17601530
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:18667074
Biological Process	GO:0060349	bone morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17693062
Biological Process	GO:0060346	bone trabecula formation	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0051216	cartilage development	Msx2	IMP		Mouse	PMID:11668602
Biological Process	GO:0051216	cartilage development	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0051216	cartilage development	Msx2	IMP		Rat	PMID:10332146\|RGD:1600462
Biological Process	GO:0042637	catagen	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0071392	cellular response to estradiol stimulus	Msx2	IDA		Mouse	PMID:8787747
Biological Process	GO:0071363	cellular response to growth factor stimulus	Msx2	IDA		Mouse	PMID:7848824
Biological Process	GO:0002063	chondrocyte development	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0042733	embryonic digit morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:21465616
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:21465616
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:21465616
Biological Process	GO:0030326	embryonic limb morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:19422820
Biological Process	GO:0030326	embryonic limb morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:15930102
Biological Process	GO:0030326	embryonic limb morphogenesis	Msx2	IGI	MGI:MGI:98297	Mouse	PMID:19422820
Biological Process	GO:0035880	embryonic nail plate morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:21465616
Biological Process	GO:0070166	enamel mineralization	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0003416	endochondral bone growth	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:18667074
Biological Process	GO:0060364	frontal suture morphogenesis	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0061180	mammary gland epithelium development	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:10742104
Biological Process	GO:0097152	mesenchymal cell apoptotic process	Msx2	IGI	MGI:MGI:98297	Mouse	PMID:19422820
Biological Process	GO:0097152	mesenchymal cell apoptotic process	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:19422820
Biological Process	GO:0043066	negative regulation of apoptotic process	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17601530
Biological Process	GO:0008285	negative regulation of cell population proliferation	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17601530
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	Msx2	IDA		Mouse	PMID:15175325
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Msx2	IDA		Mouse	MGI:MGI:3522068\|PMID:15383550
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Msx2	IDA		Mouse	PMID:15175325
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:19769717
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MSX2	IMP		Human	PMID:14671321
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Msx2	IDA		Mouse	MGI:MGI:80319\|PMID:8861098
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Msx2	IDA		Mouse	MGI:MGI:5487530\|PMID:20843790
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Msx2	IGI	MGI:MGI:98494	Mouse	PMID:18285513
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Msx2	IGI	MGI:MGI:2137495	Mouse	PMID:17030628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Msx2	IDA		Mouse	PMID:9265625
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	Msx2	IDA		Mouse	MGI:MGI:5487530\|PMID:20843790
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	Msx2	IDA		Mouse	PMID:15175325
Biological Process	GO:0042476	odontogenesis	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0001503	ossification	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0002076	osteoblast development	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0002076	osteoblast development	Msx2	IEP		Rat	PMID:11336915\|RGD:5132630
Biological Process	GO:0001649	osteoblast differentiation	Msx2	IDA		Mouse	MGI:MGI:3522068\|PMID:15383550
Biological Process	GO:0003151	outflow tract morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17601530
Biological Process	GO:0003148	outflow tract septum morphogenesis	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17601530
Biological Process	GO:0043065	positive regulation of apoptotic process	Msx2	IMP		Rat	PMID:12205674\|RGD:727419
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:18667074
Biological Process	GO:2001055	positive regulation of mesenchymal cell apoptotic process	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:19422820
Biological Process	GO:2001055	positive regulation of mesenchymal cell apoptotic process	Msx2	IGI	MGI:MGI:98297	Mouse	PMID:19422820
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Msx2	IDA		Mouse	PMID:15175325
Biological Process	GO:0051795	positive regulation of timing of catagen	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:10742104
Biological Process	GO:0042981	regulation of apoptotic process	Msx2	IDA		Mouse	PMID:18729207
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:21465616
Biological Process	GO:0048863	stem cell differentiation	Msx2	IGI	MGI:MGI:97168	Mouse	PMID:17693062
Biological Process	GO:0006366	transcription by RNA polymerase II	Msx2	IDA		Rat	PMID:7877617\|RGD:5132614
Biological Process	GO:0042060	wound healing	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:19769717
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	Msx2	IMP	MGI:MGI:1926381	Mouse	PMID:19769717

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.