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Msx2
Gene Detail
Symbol

Name
ID
Msx2
msh homeobox 2
MGI:97169
Synonyms
Hox8, Hox-8, Hox8.1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
27.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:53466884-53473074 bp, - strand
From VEGA annotation of GRCm38

  6191 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MSX2
Gene Tree: Msx2

Human
homologs
MSX2, msh homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4488
neXtProt AC: NX_P35548

Human Synonyms: CRS2, FPP, HOX8, MSH, PFM, PFM1

Human Chr (Location): 5q35.2; chr5:174724572-174730899 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human MSX2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(8) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit defective skull ossification with persistent calvarial foramen, alopecia, stubby and curly whiskers, seizures, and impaired development of teeth, cerebellum, and mammary gland.
 
Human Diseases Modeled in Mice Using Msx2 (3)    Mutations Annotated to Human Diseases (4)   
Interactions
Msx2 interacts with 186 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process activation of meiosis, anagen, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (307 records)
Data Summary: Results (668)    Tissues (455)    Images (182)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 597
Northern blot 8
Western blot 2
RT-PCR 35
RNase protection 2
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MSX2 ; Xenbase msx2 ; ZFIN msx2a, msx2b    NEW 
Molecular
reagents
All nucleic(63) Genomic(12) cDNA(40) Primer pair(10) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020950 (Evidence)
Ensembl Gene Model ENSMUSG00000021469 (Evidence)
Entrez Gene 17702 (Evidence)
UniGene 1763
DFCI TC1585930, TC1698782, TC1743292
DoTS DT.526051, DT.60109315
NIA Mouse Gene Index U034788
Consensus CDS Project CCDS26522.1
International Mouse Phenotyping Consortium Status Msx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020950 VEGA Gene Model | MGI Sequence Detail 6191 C57BL/6J ±  kb
transcript OTTMUST00000049518 VEGA | MGI Sequence Detail 2453 Not Applicable 
polypeptide OTTMUSP00000022961 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000010687 homeobox protein MSX-2
References
(Earliest) J:11121 Holland PW, Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene. 1991 Feb 15;98(2):253-7
(Latest) J:222425 Harada M, et al., Tissue-specific roles of FGF signaling in external genitalia development. Dev Dyn. 2015 Jun;244(6):759-73
All references(403)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10868, MGD-MRK-12571, MGI:2145474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory