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Msx2 Gene Detail
Summary
  • Symbol
    Msx2
  • Name
    msh homeobox 2
  • Synonyms
    Hox8, Hox-8, Hox8.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97169
    NCBI Gene: 17702
  • Gene Overview
    MyGene.info: MSX2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:53466881-53472780 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 27.84 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97169
protein coding gene Chr13:53466881-53473074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020562
protein coding gene Chr13:52804752-52810893 (-)
A/J MGP_AJ_G0020516
protein coding gene Chr13:50894323-50900472 (-)
AKR/J MGP_AKRJ_G0020494
protein coding gene Chr13:52347393-52353551 (-)
BALB/cJ MGP_BALBcJ_G0020512
protein coding gene Chr13:51117563-51123718 (-)
C3H/HeJ MGP_C3HHeJ_G0020311
protein coding gene Chr13:52192269-52198418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020946
protein coding gene Chr13:54422864-54430603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018528
protein coding gene Chr13:48899907-48906068 (-)
CAST/EiJ MGP_CASTEiJ_G0019825
protein coding gene Chr13:52221319-52227509 (-)
CBA/J MGP_CBAJ_G0020271
protein coding gene Chr13:56468670-56477056 (-)
DBA/2J MGP_DBA2J_G0020394
protein coding gene Chr13:50467157-50473310 (-)
FVB/NJ MGP_FVBNJ_G0020373
protein coding gene Chr13:49914100-49920390 (-)
LP/J MGP_LPJ_G0020470
protein coding gene Chr13:53073831-53079972 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020402
protein coding gene Chr13:56029648-56035792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020989
protein coding gene Chr13:51963335-51969482 (-)
PWK/PhJ MGP_PWKPhJ_G0019581
protein coding gene Chr13:50418918-50425120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019408
protein coding gene Chr13:50868992-50875117 (-)
WSB/EiJ MGP_WSBEiJ_G0019887
protein coding gene Chr13:52289711-52295860 (-)



Homology
more
  • Human Ortholog
    MSX2, msh homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MSX2, msh homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRS2, FPP, HOX8, MSH, PFM, PFM1
  • Links
    NCBI Gene ID: 4488
    neXtProt AC: NX_P35548
    UniProt: P35548

  • Chr Location
    5q35.2; chr5:174724495-174730899 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1837
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MSX2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Msx2 mouse models; 2 with human MSX2 associations

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    101 phenotypes from 8 alleles in 10 genetic backgrounds
    64 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defective skull ossification with persistent calvarial foramen, alopecia, stubby and curly whiskers, seizures, and impaired development of teeth, cerebellum, and mammary gland.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17702 NCBI Gene Model | MGI Sequence Detail 5900 C57BL/6J ±  kb
    transcript NM_013601 RefSeq | MGI Sequence Detail 2162 C57BL/6  
    polypeptide Q03358 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 12
      cDNA 42
      Primer pair 12
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10868, MGD-MRK-12571, MGI:2145474
    References
    more
    • Summaries
      All 466
      Developmental Gene Expression 346
      Diseases 3
      Gene Ontology 32
      Phenotypes 67
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:266544 Kim J, et al., Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory