Msx2
Gene Detail

Symbol Name ID

Msx2 homeobox, msh-like 2 MGI:97169

Synonyms

Hox8, Hox-8, Hox8.1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

27.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr13:53466881-53473074 bp, - strand From VEGA annotation of GRCm38   6194 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Msx2

Human homologs

Human Homolog		MSX2, msh homeobox 2
NCBI Gene ID		4488
neXtProt AC		NX_P35548
Human Synonyms		CRS2, FPP, HOX8, MSH, PFM, PFM1
Human Chr (Location)		5q35.2; chr5:174151575-174157902 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MSX2

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Homozygotes for a targeted null mutation exhibit defective skull ossification with persistent calvarial foramen, alopecia, stubby and curly whiskers, seizures, and impaired development of teeth, cerebellum, and mammary gland.

 
Human Diseases Modeled Using Mouse Msx2 (3)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	anagen, anterior/posterior pattern specification, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (278 records)
Data Summary: Results (630)    Tissues (432)    Images (157)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	559
Northern blot	8
Western blot	2
RT-PCR	35
RNase protection	2

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) Genomic(12) cDNA(36) Primer pair(9) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020950 (Evidence)
Ensembl Gene Model	ENSMUSG00000021469 (Evidence)
Entrez Gene	17702 (Evidence)
UniGene	1763
DFCI	TC1585930, TC1698782, TC1743292
DoTS	DT.526051, DT.60109315
NIA Mouse Gene Index	U034788
Consensus CDS Project	CCDS26522.1
International Mouse Knockout Project Status	Msx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020950	VEGA Gene Model | MGI Sequence Detail	6194	C57BL/6J
transcript	OTTMUST00000049518	VEGA | MGI Sequence Detail	2456	Not Applicable
polypeptide	OTTMUSP00000022961	VEGA | MGI Sequence Detail	267	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000010687	homeobox protein MSX-2

References

(Earliest) J:11121 Holland PW, Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene. 1991 Feb 15;98(2):253-7
(Latest) J:194129 Lallemand Y, et al., Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele. Genesis. 2013 Feb;51(2):110-9
All references(369)

Other accession IDs

MGD-MRK-10868, MGD-MRK-12571, MGI:2145474