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Msx2
Gene Detail
 Symbol
Name
ID
Msx2
msh homeobox 2
MGI:97169
Synonyms Hox8, Hox-8, Hox8.1
Feature Type protein coding gene
Genetic Map
Chromosome 13
27.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:53467877-53473074 bp, - strand
From VEGA annotation of GRCm38

  5198 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1837  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Msx2

Human
homologs
Human Homolog MSX2, msh homeobox 2
NCBI Gene ID 4488
neXtProt AC  NX_P35548
Human Synonyms  CRS2, FPP, HOX8, MSH, PFM, PFM1
Human Chr (Location)  5q35.2; chr5:174724077-174730899 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MSX2
Alleles
and
phenotypes
All alleles(11) : Targeted(7) Gene trapped(3) Chemically induced(1)
 
Homozygotes for a targeted null mutation exhibit defective skull ossification with persistent calvarial foramen, alopecia, stubby and curly whiskers, seizures, and impaired development of teeth, cerebellum, and mammary gland.
 
Human Diseases Modeled Using Mouse Msx2 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process activation of meiosis, anagen, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (287 records)
Data Summary: Results (629)    Tissues (439)    Images (159)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 24
RNA in situ 558
Northern blot 8
Western blot 2
RT-PCR 35
RNase protection 2
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(61) Genomic(12) cDNA(39) Primer pair(9) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020950 (Evidence)
Ensembl Gene ModelENSMUSG00000021469 (Evidence)
Entrez Gene17702 (Evidence)
UniGene1763
DFCITC1585930, TC1698782, TC1743292
DoTSDT.526051, DT.60109315
NIA Mouse Gene IndexU034788
Consensus CDS ProjectCCDS26522.1
International Mouse Knockout Project StatusMsx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020950 VEGA Gene Model | MGI Sequence Detail 5198 C57BL/6J ±  kb
transcript OTTMUST00000049518 VEGA | MGI Sequence Detail 1460 Not Applicable 
polypeptide OTTMUSP00000022961 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000010687 homeobox protein MSX-2
References (Earliest) J:11121 Holland PW, Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene. 1991 Feb 15;98(2):253-7
(Latest) J:200023 Farin HF, et al., Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet. 2013;9(4):e1003467
All references(382)
Other
accession IDs
MGD-MRK-10868, MGD-MRK-12571, MGI:2145474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory