Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MITF
  • Mouse genes Mitf
  • Rat genes Mitf
  • Zfish genes mitfa,mitfb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mitf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Mitf	IDA		Mouse	PMID:15729346
Molecular Function	GO:0003677	DNA binding	Mitf	IDA		Mouse	PMID:14575687
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MITF	IDA		Human	PMID:14737107
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MITF	IMP		Human	PMID:14737107
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MITF	IDA		Human	PMID:20530484
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mitf	IDA		Mouse	MGI:MGI:3529668|PMID:15716956
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mitf	IDA		Mouse	PMID:12235125
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mitf	IDA		Mouse	PMID:14575687
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Mitf	IMP		Mouse	MGI:MGI:5461240|PMID:23207919
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Mitf	IDA		Mouse	PMID:15729346
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	mitfa	IDA		Zfish	ZFIN:ZDB-PUB-010813-3|PMID:11543618
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	mitfb	IDA		Zfish	PMID:11543618
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	mitfa	IDA		Zfish	PMID:11543618
Molecular Function	GO:0070888	E-box binding	MITF	IDA		Human	PMID:27889061
Molecular Function	GO:0070888	E-box binding	Mitf	IDA		Mouse	MGI:MGI:5461240|PMID:23207919
Molecular Function	GO:0005515	protein binding	MITF	IPI	UniProtKB:P48436	Human	PMID:20530484
Molecular Function	GO:0005515	protein binding	MITF	IPI	UniProtKB:Q92995	Human	PMID:21811243
Molecular Function	GO:0005515	protein binding	MITF	IPI	UniProtKB:Q00610	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Mitf	IPI	PR:O54714	Mouse	PMID:17442941
Molecular Function	GO:0046983	protein dimerization activity	Mitf	IPI	UniProtKB:Q08874	Mouse	MGI:MGI:5461240|PMID:23207919
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	MITF	IDA		Human	PMID:14737107
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mitf	IDA		Mouse	MGI:MGI:3529668|PMID:15716956
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mitf	IDA		Mouse	PMID:23980096
Cellular Component	GO:0005737	cytoplasm	MITF	IDA		Human	PMID:28842328
Cellular Component	GO:0005634	nucleus	MITF	IDA		Human	PMID:27889061
Cellular Component	GO:0005634	nucleus	MITF	IDA		Human	PMID:28842328
Cellular Component	GO:0005634	nucleus	Mitf	IDA		Mouse	PMID:12235125
Cellular Component	GO:0032991	protein-containing complex	MITF	IDA		Human	PMID:20530484
Biological Process	GO:0046849	bone remodeling	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0043010	camera-type eye development	Mitf	IGI	MGI:MGI:88401	Mouse	PMID:15576400
Biological Process	GO:0030154	cell differentiation	Mitf	IMP	MGI:MGI:1856094	Mouse	PMID:9199364
Biological Process	GO:0045165	cell fate commitment	Mitf	IMP	MGI:MGI:1856085	Mouse	PMID:15576400
Biological Process	GO:0034224	cellular response to zinc ion starvation	Mitf	IEP		Rat	PMID:21893222|RGD:151667428
Biological Process	GO:0007623	circadian rhythm	mitfa	IDA		Zfish	PMID:26278158
Biological Process	GO:0061386	closure of optic fissure	mitfa	IGI	ZFIN:ZDB-GENO-211027-12	Zfish	PMID:32541011
Biological Process	GO:0006351	DNA-templated transcription	Mitf	IDA		Rat	PMID:19524539|RGD:12793003
Biological Process	GO:0006351	DNA-templated transcription	mitfb	IDA		Zfish	PMID:11543618|ZFIN:ZDB-PUB-010813-3
Biological Process	GO:0006351	DNA-templated transcription	mitfb	IDA		Zfish	PMID:11543618
Biological Process	GO:0006351	DNA-templated transcription	mitfa	IDA		Zfish	PMID:11543618
Biological Process	GO:1902362	melanocyte apoptotic process	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0030318	melanocyte differentiation	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0030318	melanocyte differentiation	Mitf	IGI	MGI:MGI:88138	Mouse	PMID:12086670
Biological Process	GO:0030318	melanocyte differentiation	Mitf	IMP	MGI:MGI:1856088	Mouse	PMID:2379821
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-110330-4	Zfish	PMID:28249010
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IGI	ZFIN:ZDB-GENE-011212-6	Zfish	PMID:28249010
Biological Process	GO:0030318	melanocyte differentiation	mitfb	IGI	ZFIN:ZDB-GENE-990910-11	Zfish	PMID:11543618
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IGI	ZFIN:ZDB-MRPHLNO-060927-2,ZFIN:ZDB-MRPHLNO-101013-2	Zfish	PMID:20862309
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-990423-18	Zfish	PMID:10433906
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-070315-1	Zfish	PMID:20862309
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-110330-3	Zfish	PMID:21146516
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-100727-8	Zfish	PMID:25535837
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP		Zfish	PMID:11543618
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-100727-8	Zfish	PMID:21146516
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-MRPHLNO-050201-1	Zfish	PMID:15300437
Biological Process	GO:0030318	melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-MRPHLNO-130429-1	Zfish	PMID:23364329
Biological Process	GO:0043066	negative regulation of apoptotic process	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0030336	negative regulation of cell migration	MITF	IMP		Human	PMID:19188590
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MITF	IMP		Human	PMID:24769727
Biological Process	GO:0030316	osteoclast differentiation	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0030316	osteoclast differentiation	Mitf	IEP		Rat	PMID:22576626|RGD:151667429
Biological Process	GO:0043473	pigmentation	Mitf	IGI	MGI:MGI:88138	Mouse	PMID:12086670
Biological Process	GO:0043473	pigmentation	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0043473	pigmentation	Mitf	IMP	MGI:MGI:1856088	Mouse	PMID:2379821
Biological Process	GO:0043473	pigmentation	mitfa	IMP	ZFIN:ZDB-GENO-100727-8	Zfish	PMID:25214630
Biological Process	GO:0043473	pigmentation	mitfa	IGI	ZFIN:ZDB-GENE-011212-6	Zfish	PMID:28249010
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MITF	IDA		Human	PMID:9647758
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mitf	IDA		Mouse	PMID:14575687
Biological Process	GO:2000144	positive regulation of DNA-templated transcription initiation	MITF	IDA		Human	PMID:12204775
Biological Process	GO:2000144	positive regulation of DNA-templated transcription initiation	MITF	IDA		Human	PMID:8995290
Biological Process	GO:0010628	positive regulation of gene expression	MITF	IDA		Human	PMID:22234890
Biological Process	GO:0010628	positive regulation of gene expression	MITF	IMP		Human	PMID:22234890
Biological Process	GO:0010628	positive regulation of gene expression	MITF	IMP		Human	PMID:22523078
Biological Process	GO:0045636	positive regulation of melanocyte differentiation	mitfa	IMP	ZFIN:ZDB-GENO-100727-8	Zfish	PMID:33439865
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MITF	IMP		Human	PMID:14737107
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MITF	IDA		Human	PMID:20530484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MITF	IDA		Human	PMID:21209915
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mitf	IGI	UniProtKB:Q9R0G7	Mouse	MGI:MGI:5574413|PMID:24769727
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mitf	IDA		Mouse	MGI:MGI:5306313|PMID:15304486
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mitf	IDA		Mouse	MGI:MGI:3529668|PMID:15716956
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mitf	IGI	MGI:MGI:98358	Mouse	PMID:15729346
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mitf	IDA		Mouse	PMID:17442941
Biological Process	GO:0065003	protein-containing complex assembly	MITF	IDA		Human	PMID:20530484
Biological Process	GO:0042127	regulation of cell population proliferation	Mitf	IDA		Mouse	PMID:12235125
Biological Process	GO:0006355	regulation of DNA-templated transcription	MITF	IMP		Human	PMID:27889061
Biological Process	GO:0010468	regulation of gene expression	Mitf	IMP	MGI:MGI:1856095	Mouse	PMID:12086670
Biological Process	GO:0045670	regulation of osteoclast differentiation	Mitf	IGI	MGI:MGI:98511	Mouse	PMID:11930005
Biological Process	GO:0045670	regulation of osteoclast differentiation	Mitf	IMP	MGI:MGI:1856085	Mouse	PMID:11930005
Biological Process	GO:2001141	regulation of RNA biosynthetic process	MITF	IDA		Human	PMID:16411896
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Mitf	IMP		Mouse	MGI:MGI:5461240|PMID:23207919
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Mitf	IDA		Mouse	PMID:12235125
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	mitfb	IDA		Zfish	PMID:11543618|ZFIN:ZDB-PUB-010813-3
Biological Process	GO:0045471	response to ethanol	Mitf	IEP		Rat	PMID:22576626|RGD:151667429
Biological Process	GO:0016055	Wnt signaling pathway	Mitf	IDA		Mouse	PMID:12235125

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern