Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MEF2A
  • Mouse genes Mef2a
  • Rat genes Mef2a
  • Zfish genes mef2aa,mef2ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mef2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	MEF2A	IDA		Human	PMID:21468593
Molecular Function	GO:0003682	chromatin binding	Mef2a	IDA		Mouse	PMID:16407236
Molecular Function	GO:0003682	chromatin binding	Mef2a	IDA		Mouse	PMID:21379568
Molecular Function	GO:0003682	chromatin binding	Mef2a	IDA		Mouse	PMID:18198354
Molecular Function	GO:0003677	DNA binding	Mef2a	IDA		Mouse	PMID:9738004
Molecular Function	GO:0003677	DNA binding	Mef2a	IDA		Mouse	PMID:15491989
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MEF2A	IDA		Human	PMID:15466416
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	MEF2A	IDA		Human	PMID:7760790
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Mef2a	IDA		Mouse	PMID:16407236
Molecular Function	GO:0003700	DNA-binding transcription factor activity	MEF2A	IDA		Human	PMID:16043483
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mef2a	IDA		Mouse	PMID:9738004
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Mef2a	IDA		Mouse	PMID:12130539
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	MEF2A	IDA		Human	PMID:10748098
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	MEF2A	IDA		Human	PMID:16484498
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	MEF2A	IDA		Human	PMID:20590529
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Mef2a	IDA		Mouse	PMID:21379568
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Mef2a	IDA		Rat	PMID:10521511|RGD:8553671
Molecular Function	GO:0140297	DNA-binding transcription factor binding	MEF2A	IPI	UniProtKB:Q14814	Human	PMID:20590529
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Mef2a	IPI	UniProtKB:Q62432	Mouse	MGI:MGI:5009194|PMID:11160896
Molecular Function	GO:0035035	histone acetyltransferase binding	MEF2A	IPI	UniProtKB:Q09472	Human	PMID:20590529
Molecular Function	GO:0042826	histone deacetylase binding	MEF2A	IPI	UniProtKB:Q6NZM9	Human	PMID:10748098
Molecular Function	GO:0042826	histone deacetylase binding	MEF2A	IPI	UniProtKB:Q9UKV0	Human	PMID:10748098
Molecular Function	GO:0042826	histone deacetylase binding	MEF2A	IPI	UniProtKB:Q9Z2V6	Human	PMID:10748098
Molecular Function	GO:0042826	histone deacetylase binding	MEF2A	IPI	UniProtKB:Q13547	Human	PMID:20590529
Molecular Function	GO:0042826	histone deacetylase binding	MEF2A	IPI	UniProtKB:Q8WUI4	Human	PMID:20590529
Molecular Function	GO:0005515	protein binding	MEF2A	IPI	UniProtKB:Q92793	Human	PMID:16043483
Molecular Function	GO:0005515	protein binding	MEF2A	IPI	UniProtKB:Q99697-3	Human	PMID:15466416
Molecular Function	GO:0005515	protein binding	MEF2A	IPI	UniProtKB:P70257-2	Human	PMID:20178747
Molecular Function	GO:0005515	protein binding	MEF2A	IPI	UniProtKB:P10085	Human	PMID:7973707
Molecular Function	GO:0005515	protein binding	Mef2a	IPI	UniProtKB:P70257-2	Mouse	MGI:MGI:4454367|PMID:20178747
Molecular Function	GO:0005515	protein binding	Mef2a	IPI	UniProtKB:P12979	Mouse	MGI:MGI:6718239|PMID:7973707
Molecular Function	GO:0005515	protein binding	Mef2a	IPI	PR:Q9EPW2	Mouse	PMID:12097321
Molecular Function	GO:0046982	protein heterodimerization activity	MEF2A	IPI	UniProtKB:Q63943	Human	PMID:9858528
Molecular Function	GO:0019901	protein kinase binding	Mef2a	IPI	UniProtKB:O54949	Mouse	MGI:MGI:3843420|PMID:17785444
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	MEF2A	IDA		Human	PMID:7760790
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mef2a	IDA		Mouse	MGI:MGI:5572905|PMID:9430690
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Mef2a	IDA		Mouse	PMID:22194471
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	MEF2A	IDA		Human	PMID:20590529
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	MEF2A	IPI	UniProtKB:Q99697-3	Human	PMID:15466416
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	MEF2A	IPI	UniProtKB:O96004	Human	PMID:16043483
Molecular Function	GO:0043565	sequence-specific DNA binding	MEF2A	IDA		Human	PMID:10835359
Molecular Function	GO:0043565	sequence-specific DNA binding	Mef2a	IDA		Mouse	PMID:8096811
Molecular Function	GO:0043565	sequence-specific DNA binding	Mef2a	IDA		Rat	PMID:10521511|RGD:8553671
Molecular Function	GO:0046332	SMAD binding	MEF2A	IPI	UniProtKB:Q15796	Human	PMID:11160896
Molecular Function	GO:0000976	transcription cis-regulatory region binding	mef2aa	IDA		Zfish	PMID:8951797
Cellular Component	GO:0000785	chromatin	Mef2a	IDA		Mouse	MGI:MGI:4838688|PMID:20833138
Cellular Component	GO:0005829	cytosol	MEF2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	MEF2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MEF2A	IDA		Human	PMID:16484498
Cellular Component	GO:0005634	nucleus	MEF2A	IDA		Human	PMID:20590529
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Mouse	MGI:MGI:5009194|PMID:11160896
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Mouse	PMID:9013788
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Mouse	PMID:15491989
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Mouse	PMID:17431507
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Mouse	PMID:18198354
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Mouse	PMID:22194471
Cellular Component	GO:0005634	nucleus	Mef2a	IDA		Rat	PMID:17696759|RGD:8553739
Cellular Component	GO:0005667	transcription regulator complex	MEF2A	IDA		Human	PMID:16043483
Biological Process	GO:0061337	cardiac conduction	Mef2a	IMP		Mouse	MGI:MGI:2429350|PMID:12379849
Biological Process	GO:0071277	cellular response to calcium ion	MEF2A	IDA		Human	PMID:16484498
Biological Process	GO:0071277	cellular response to calcium ion	Mef2a	IDA		Rat	PMID:10521511|RGD:8553671
Biological Process	GO:0071333	cellular response to glucose stimulus	Mef2a	IEP		Rat	PMID:18413674|RGD:2312263
Biological Process	GO:0048813	dendrite morphogenesis	Mef2a	IMP		Rat	PMID:16484498|RGD:8553655
Biological Process	GO:0006351	DNA-templated transcription	MEF2A	IDA		Human	PMID:16043483
Biological Process	GO:0070375	ERK5 cascade	MEF2A	IMP		Human	PMID:15132737
Biological Process	GO:0007507	heart development	MEF2A	IEP		Human	PMID:10458488
Biological Process	GO:0007507	heart development	mef2aa	IMP	ZFIN:ZDB-MRPHLNO-050914-1	Zfish	PMID:17367767
Biological Process	GO:0000165	MAPK cascade	MEF2A	IDA		Human	PMID:9858528
Biological Process	GO:0000002	mitochondrial genome maintenance	Mef2a	IMP		Mouse	MGI:MGI:2429350|PMID:12379849
Biological Process	GO:0048311	mitochondrion distribution	Mef2a	IMP		Mouse	MGI:MGI:2429350|PMID:12379849
Biological Process	GO:0030239	myofibril assembly	mef2aa	IMP	ZFIN:ZDB-MRPHLNO-050914-1	Zfish	PMID:16107252
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:16484498
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	MEF2A	IDA		Human	PMID:24161931
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	MEF2A	IGI	UniProtKB:P61296	Human	PMID:24161931
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mef2a	IDA		Mouse	PMID:12097321
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Mef2a	IMP		Rat	PMID:17696759|RGD:8553739
Biological Process	GO:0010628	positive regulation of gene expression	Mef2a	IDA		Mouse	PMID:29606596
Biological Process	GO:0010628	positive regulation of gene expression	mef2aa	IMP	ZFIN:ZDB-MRPHLNO-050914-1	Zfish	PMID:19517572
Biological Process	GO:0046326	positive regulation of glucose import	Mef2a	IDA		Mouse	PMID:12097321
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:10748098
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:15466416
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:20590529
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:21468593
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:7760790
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MEF2A	IDA		Human	PMID:9858528
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2a	IDA		Mouse	MGI:MGI:3639834|PMID:16407236
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2a	IGI	MGI:MGI:97276	Mouse	PMID:20399744
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2a	IGI	MGI:MGI:98510	Mouse	PMID:8900141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2a	IGI	MGI:MGI:96919	Mouse	PMID:8900141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2a	IDA		Rat	PMID:10521511|RGD:8553671
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Mef2a	IMP		Rat	PMID:26240138|RGD:13210532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	mef2aa	IDA		Zfish	PMID:8951797
Biological Process	GO:0006355	regulation of DNA-templated transcription	Mef2a	IDA		Mouse	PMID:12130539
Biological Process	GO:0006355	regulation of DNA-templated transcription	Mef2a	IDA		Mouse	PMID:9738004
Biological Process	GO:0001756	somitogenesis	mef2aa	IMP	ZFIN:ZDB-MRPHLNO-050914-1	Zfish	PMID:16942865
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	Mef2a	IMP		Mouse	MGI:MGI:2429350|PMID:12379849

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern