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Mef2a Gene Detail
Summary
  • Symbol
    Mef2a
  • Name
    myocyte enhancer factor 2A
  • Synonyms
    A430079H05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99532
    NCBI Gene: 17258
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:66880911-67022606 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 36.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    476 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99532
protein coding gene Chr7:66880911-67026435 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032358
protein coding gene Chr7:68480080-68624635 (-)
A/J MGP_AJ_G0032337
protein coding gene Chr7:67074194-67214474 (-)
AKR/J MGP_AKRJ_G0032273
protein coding gene Chr7:68493585-68632107 (-)
BALB/cJ MGP_BALBcJ_G0032349
protein coding gene Chr7:66808932-66951436 (-)
C3H/HeJ MGP_C3HHeJ_G0032062
protein coding gene Chr7:69183121-69325003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032841
protein coding gene Chr7:71418143-71572481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029848
protein coding gene Chr7:69951455-70074359 (-)
CAST/EiJ MGP_CASTEiJ_G0031390
protein coding gene Chr7:59870341-60015577 (-)
CBA/J MGP_CBAJ_G0032028
protein coding gene Chr7:73659634-73809259 (-)
DBA/2J MGP_DBA2J_G0032183
protein coding gene Chr7:65793241-65933553 (-)
FVB/NJ MGP_FVBNJ_G0032138
protein coding gene Chr7:65911823-66052881 (-)
LP/J MGP_LPJ_G0032264
protein coding gene Chr7:69707272-69849205 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032175
protein coding gene Chr7:73860266-74032517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032859
protein coding gene Chr7:67852222-67998341 (-)
PWK/PhJ MGP_PWKPhJ_G0031110
protein coding gene Chr7:58842285-58978877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030951
protein coding gene Chr7:54903387-55040741 (-)
WSB/EiJ MGP_WSBEiJ_G0031508
protein coding gene Chr7:68198348-68333087 (-)



Homology
more
  • Human Ortholog
    MEF2A, myocyte enhancer factor 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEF2A, myocyte enhancer factor 2A
  • Synonyms
    ADCAD1, mef2, RSRFC4, RSRFC9
  • Links
    NCBI Gene ID: 4205
    neXtProt AC: NX_Q02078
    UniProt: Q02078

  • Chr Location
    15q26.3; chr15:99565417-99716488 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human MEF2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in cardiac sudden death. Mice dying in the early postnatal period exhibit ventricular dilation, while mice dying in adulthood show a reduced number of mitochondria in the heart.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030557 Ensembl Gene Model | MGI Sequence Detail 141696 C57BL/6J ±  kb
    transcript ENSMUST00000156690 Ensembl | MGI Sequence Detail 5538 Not Applicable  
    polypeptide ENSMUSP00000117496 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 23
      Primer pair 7
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-16310, MGI:2445167
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 40
      Gene Ontology 26
      Phenotypes 38
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:338901 Boogerd CJ, et al., Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023 Aug 5;14(1):4716

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory