About   Help   FAQ
Mef2a Gene Detail
Summary
  • Symbol
    Mef2a
  • Name
    myocyte enhancer factor 2A
  • Synonyms
    A430079H05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99532
    NCBI Gene: 17258
Location & Maps
more
  • Sequence Map
    Chr7:67231163-67372858 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      141696 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 36.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MEF2A, myocyte enhancer factor 2A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEF2A, myocyte enhancer factor 2A
    Orthology source: HomoloGene
  • Synonyms
    ADCAD1, mef2, RSRFC4, RSRFC9
  • Links
    NCBI Gene ID: 4205
    neXtProt AC: NX_Q02078

  • Chr Location
    15q26; chr15:99565533-99716483 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MEF2A associations

Human Disease Mouse Models
       Coronary Artery Disease, Autosomal Dominant, 1; ADCAD1   OMIM: 608320
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Mef2a
  • Incidental Mutations
Inactivation of this gene results in cardiac sudden death. Mice dying in the early postnatal period exhibit ventricular dilation, while mice dying in adulthood show a reduced number of mitochondria in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021127 VEGA Gene Model | MGI Sequence Detail 141696 C57BL/6J ±  kb
transcript OTTMUST00000050021 VEGA | MGI Sequence Detail 5538 Not Applicable  
polypeptide OTTMUSP00000023285 VEGA | MGI Sequence Detail 498 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    480 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010309 myocyte-specific enhancer factor 2A
  • InterPro Domains
    IPR022102 Holliday junction regulator protein family C-terminal
    IPR002100 Transcription factor, MADS-box
Molecular
Reagents
less
  • All nucleic 27
    cDNA 21
    Primer pair 5
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-16310, MGI:2445167
References
more
  • Summaries
    All 97
    Developmental Gene Expression 31
    Gene Ontology 23
    Phenotypes 28
  • Earliest
    J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
  • Latest
    J:230599 Latchney SE, et al., Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. FASEB J. 2015 Dec;29(12):5059-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory