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Mef2a
Gene Detail
 Symbol
Name
ID
Mef2a
myocyte enhancer factor 2A
MGI:99532
Synonyms A430079H05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
36.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:67231163-67372858 bp, - strand
From VEGA annotation of GRCm38

  141696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mef2a

Human
homologs
Human Homolog MEF2A, myocyte enhancer factor 2A
NCBI Gene ID 4205
neXtProt AC  NX_Q02078
Human Synonyms  ADCAD1, mef2, RSRFC4, RSRFC9
Human Chr (Location)  15q26; chr15:99565583-99716483 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MEF2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene results in cardiac sudden death. Mice dying in the early postnatal period exhibit ventricular dilation, while mice dying in adulthood show a reduced number of mitochondria in the heart.
 
Interactions
Mef2a interacts with 472 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process apoptotic process, cardiac conduction, ...
Component cytoplasm, nuclear chromatin, ...
Function activating transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (254)    Tissues (207)    Images (30)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 42
RNA in situ 189
Western blot 4
RT-PCR 19
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(21) Primer pair(5) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000021127 (Evidence)
Ensembl Gene ModelENSMUSG00000030557 (Evidence)
Entrez Gene17258 (Evidence)
DFCITC1581428, TC1588061, TC1624123, TC1633819
DoTSDT.101709340, DT.523778, DT.94260700, DT.94341745, DT.97406528
Consensus CDS ProjectCCDS39981.1, CCDS71979.1, CCDS71980.1
International Mouse Knockout Project StatusMef2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021127 VEGA Gene Model | MGI Sequence Detail 141696 C57BL/6J ±  kb
transcript OTTMUST00000050021 VEGA | MGI Sequence Detail 5538 Not Applicable 
polypeptide OTTMUSP00000023285 VEGA | MGI Sequence Detail 498 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(18) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022102 Holliday junction regulator protein family C-terminal
InterPro IPR002100 Transcription factor, MADS-box
Protein Ontology PR:000010309 myocyte-specific enhancer factor 2A
References (Earliest) J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
(Latest) J:196361 Cappellari O, et al., Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013 Mar 25;24(6):586-99
All references(94)
Other
accession IDs
MGD-MRK-16310, MGI:2445167

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory