Mef2a
Gene Detail

Symbol Name ID

Mef2a myocyte enhancer factor 2A MGI:99532

Synonyms

A430079H05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

36.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:67231163-67372858 bp, - strand From VEGA annotation of GRCm38   141696 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4080  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mef2a

Human homologs

Human Homolog		MEF2A, myocyte enhancer factor 2A
NCBI Gene ID		4205
neXtProt AC		NX_Q02078
Human Synonyms		ADCAD1, mef2, RSRFC4, RSRFC9
Human Chr (Location)		15q26; chr15:100106133-100256630 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MEF2A

Alleles and phenotypes

All alleles(25) : Targeted(4) Gene trapped(21)
 

Inactivation of this gene results in cardiac sudden death. Mice dying in the early postnatal period exhibit ventricular dilation, while mice dying in adulthood show a reduced number of mitochondria in the heart.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	apoptotic process, cardiac conduction, ...
Component	nuclear chromatin, nucleus
Function	activating transcription factor binding, chromatin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (261)    Tissues (212)    Images (30)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	42
RNA in situ	189
Western blot	4
RT-PCR	26

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(20) Primer pair(5) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000021127 (Evidence)
Ensembl Gene Model	ENSMUSG00000030557 (Evidence)
Entrez Gene	17258 (Evidence)
DFCI	TC1581428, TC1588061, TC1624123
DoTS	DT.101709340, DT.523778, DT.94260700, DT.94341745, DT.97406528
Consensus CDS Project	CCDS39981.1
International Mouse Knockout Project Status	Mef2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021127	VEGA Gene Model | MGI Sequence Detail	141696	C57BL/6J
transcript	OTTMUST00000050021	VEGA | MGI Sequence Detail	5538	Not Applicable
polypeptide	OTTMUSP00000023285	VEGA | MGI Sequence Detail	498	Not Applicable

All sequences(60) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(397 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022102	Holliday junction regulator protein family C-terminal
InterPro	IPR002100	Transcription factor, MADS-box
Protein Ontology	PR:000010309	myocyte-specific enhancer factor 2A

References

(Earliest) J:4385 Komuro I, et al., Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J. 1993 Apr;12(4):1387-401
(Latest) J:191077 Snyder CM, et al., MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration. Development. 2013 Jan 1;140(1):31-42
All references(90)

Other accession IDs

MGD-MRK-16310, MGI:2445167