Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Map2k1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MAP2K1
- Mouse genes Map2k1
- Rat genes Map2k1
- Zfish genes map2k1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Map2k1	IDA		Rat	PMID:7611406\|RGD:2298674
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K1	IDA		Human	PMID:28166211
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K1	IDA		Human	PMID:8388392
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k1	IDA		Mouse	PMID:1411546
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k1	IMP		Mouse	PMID:11841548
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k1	IDA		Rat	PMID:7611406\|RGD:2298674
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k1	IDA		Rat	PMID:7624324\|RGD:1582177
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k1	IDA		Rat	PMID:7935430\|RGD:2293305
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k1	IDA		Rat	PMID:8393135\|RGD:61657
Molecular Function	GO:0005078	MAP-kinase scaffold activity	MAP2K1	IMP		Human	PMID:29433126
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Map2k1	IPI	RGD:620966	Rat	PMID:16006144\|RGD:2293486
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Map2k1	IDA		Rat	PMID:7565670\|RGD:2293209
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q96RU7	Human	PMID:15299019
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:O15519-1	Human	PMID:17110930
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P28482	Human	PMID:17255949
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:17724343
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q9NR09	Human	PMID:18329369
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:19197339
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P27361	Human	PMID:19197339
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q13526	Human	PMID:20179161
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P63085	Human	PMID:20554783
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q86Y07	Human	PMID:20679487
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q61097	Human	PMID:21441104
Molecular Function	GO:0005515	protein binding	MAP2K1	IDA		Human	PMID:22572157
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q86Y07-1	Human	PMID:22752157
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P28482	Human	PMID:23241949
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:23934108
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:23934108
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P46937	Human	PMID:24211253
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q9Y297	Human	PMID:24211253
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:25155755
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:25155755
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q8N9N5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:25437913
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:25600339
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q8IVT5	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q8N9N5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q8WWU5-7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P04049	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P15056	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAP2K1	IPI	UniProtKB:P28482	Human	PMID:32721402
Molecular Function	GO:0005515	protein binding	Map2k1	IPI	UniProtKB:Q8CFP6	Mouse	MGI:MGI:5571536\|PMID:24746703
Molecular Function	GO:0005515	protein binding	Map2k1	IPI	UniProtKB:Q9ESN9-2	Mouse	MGI:MGI:1890011\|PMID:10523642
Molecular Function	GO:0005515	protein binding	Map2k1	IPI	UniProtKB:Q13526	Mouse	MGI:MGI:5285164\|PMID:20179103
Molecular Function	GO:0005515	protein binding	Map2k1	IPI	RGD:1308105	Rat	PMID:16272159\|RGD:2298675
Molecular Function	GO:0030295	protein kinase activator activity	MAP2K1	IDA		Human	PMID:10644344
Molecular Function	GO:0019901	protein kinase binding	Map2k1	IPI	RGD:737237	Rat	PMID:15917294\|RGD:2292643
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	MAP2K1	IDA		Human	PMID:8388392
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Map2k1	IDA		Mouse	PMID:1411546
Molecular Function	GO:0044877	protein-containing complex binding	Map2k1	IPI	RGD:737237\|RGD:2827\|RGD:619908	Rat	PMID:15917294\|RGD:2292643
Molecular Function	GO:0097110	scaffold protein binding	MAP2K1	IPI	UniProtKB:Q61097	Human	PMID:10409742
Molecular Function	GO:0031267	small GTPase binding	Map2k1	IPI	RGD:730881	Rat	PMID:7935430\|RGD:2293305
Cellular Component	GO:0030424	axon	Map2k1	IDA		Rat	PMID:9714150\|RGD:2293331
Cellular Component	GO:0005938	cell cortex	Map2k1	IDA		Rat	PMID:16272159\|RGD:2298675
Cellular Component	GO:0005829	cytosol	MAP2K1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Map2k1	IDA		Rat	PMID:16272159\|RGD:2298675
Cellular Component	GO:0005829	cytosol	Map2k1	IDA		Rat	PMID:9779826\|RGD:70317
Cellular Component	GO:0030425	dendrite	Map2k1	IDA		Rat	PMID:10465442\|RGD:2293321
Cellular Component	GO:0032839	dendrite cytoplasm	Map2k1	IDA		Rat	PMID:9714150\|RGD:2293331
Cellular Component	GO:0005783	endoplasmic reticulum	MAP2K1	IDA		Human	PMID:22572157
Cellular Component	GO:0098978	glutamatergic synapse	Map2k1	EXP		Rat	PMID:12202034\|RGD:13702166
Cellular Component	GO:0098978	glutamatergic synapse	Map2k1	IDA		Rat	PMID:12202034\|RGD:13702166
Cellular Component	GO:0005794	Golgi apparatus	Map2k1	IDA		Rat	PMID:12695496\|RGD:1582173
Cellular Component	GO:0005874	microtubule	Map2k1	IDA		Rat	PMID:10465442\|RGD:2293321
Cellular Component	GO:0043204	perikaryon	Map2k1	IDA		Rat	PMID:10465442\|RGD:2293321
Cellular Component	GO:0043204	perikaryon	Map2k1	IDA		Rat	PMID:9714150\|RGD:2293331
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Map2k1	IDA		Rat	PMID:12876277\|RGD:2293211
Cellular Component	GO:0005886	plasma membrane	MAP2K1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Map2k1	IDA		Rat	PMID:12876277\|RGD:2293211
Cellular Component	GO:0014069	postsynaptic density	Map2k1	IDA		Rat	PMID:7478291\|RGD:13702331
Biological Process	GO:0060020	Bergmann glial cell differentiation	Map2k1	IGI	MGI:MGI:99511	Mouse	PMID:24431450
Biological Process	GO:0048870	cell motility	Map2k1	IMP	MGI:MGI:2178132	Mouse	PMID:10209122
Biological Process	GO:0008283	cell population proliferation	Map2k1	IDA		Rat	PMID:16481589\|RGD:1582172
Biological Process	GO:0090398	cellular senescence	MAP2K1	IMP		Human	PMID:9765203
Biological Process	GO:0021697	cerebellar cortex formation	Map2k1	IGI	MGI:MGI:99511	Mouse	PMID:24431450
Biological Process	GO:0035987	endodermal cell differentiation	Map2k1	IDA		Mouse	PMID:16908534
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:25100655
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:25100655
Biological Process	GO:0060324	face development	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:18952847
Biological Process	GO:0042593	glucose homeostasis	Map2k1	IDA		Rat	PMID:26581593\|RGD:12879823
Biological Process	GO:0048313	Golgi inheritance	Map2k1	IMP		Rat	PMID:9458043\|RGD:2293212
Biological Process	GO:0007507	heart development	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:18952847
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Map2k1	IMP		Mouse	PMID:21699731
Biological Process	GO:0030216	keratinocyte differentiation	Map2k1	IMP		Mouse	PMID:11841548
Biological Process	GO:0060711	labyrinthine layer development	Map2k1	IMP	MGI:MGI:2178132	Mouse	PMID:10209122
Biological Process	GO:0060425	lung morphogenesis	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:25100655
Biological Process	GO:0032402	melanosome transport	Map2k1	IDA		Rat	PMID:15753041\|RGD:2293208
Biological Process	GO:0000278	mitotic cell cycle	Map2k1	IDA		Rat	PMID:12695496\|RGD:1582173
Biological Process	GO:0008285	negative regulation of cell population proliferation	MAP2K1	IDA		Human	PMID:9765203
Biological Process	GO:0010629	negative regulation of gene expression	Map2k1	IGI	UniProtKB:P36506	Rat	PMID:28947594\|RGD:13524616
Biological Process	GO:0034111	negative regulation of homotypic cell-cell adhesion	Map2k1	IMP		Rat	PMID:17183546\|RGD:2292641
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Map2k1	IGI	UniProtKB:P06733	Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Map2k1	IMP		Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:0030182	neuron differentiation	Map2k1	IMP		Mouse	PMID:15145949
Biological Process	GO:0030182	neuron differentiation	Map2k1	IMP		Rat	PMID:17202850\|RGD:2292642
Biological Process	GO:0048812	neuron projection morphogenesis	Map2k1	IMP		Rat	PMID:17202850\|RGD:2292642
Biological Process	GO:0060674	placenta blood vessel development	Map2k1	IMP	MGI:MGI:2178132	Mouse	PMID:10209122
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	Map2k1	IGI	UniProtKB:P06733	Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	Map2k1	IMP		Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:0010508	positive regulation of autophagy	Map2k1	IDA		Rat	PMID:26581593\|RGD:12879823
Biological Process	GO:0050772	positive regulation of axonogenesis	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:24733831
Biological Process	GO:0050772	positive regulation of axonogenesis	Map2k1	IGI	MGI:MGI:88190	Mouse	PMID:24733831
Biological Process	GO:0030335	positive regulation of cell migration	Map2k1	IMP		Rat	PMID:17183546\|RGD:2292641
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP2K1	IMP		Human	PMID:24375836
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP2K1	IMP		Human	PMID:26514923
Biological Process	GO:1903226	positive regulation of endodermal cell differentiation	Map2k1	IDA		Mouse	PMID:16908534
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MAP2K1	IMP		Human	PMID:24375836
Biological Process	GO:0010628	positive regulation of gene expression	MAP2K1	IMP		Human	PMID:15155804
Biological Process	GO:0010628	positive regulation of gene expression	MAP2K1	IMP		Human	PMID:24375836
Biological Process	GO:0010628	positive regulation of gene expression	Map2k1	IGI	UniProtKB:P09416	Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:0010628	positive regulation of gene expression	Map2k1	IMP		Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:0043547	positive regulation of GTPase activity	Map2k1	IMP		Rat	PMID:17183546\|RGD:2292641
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k1	IMP		Mouse	PMID:15896720
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k1	IDA		Rat	PMID:7935430\|RGD:2293305
Biological Process	GO:0045933	positive regulation of muscle contraction	Map2k1	IGI	UniProtKB:P06733	Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:0045933	positive regulation of muscle contraction	Map2k1	IMP		Rat	PMID:15459207\|RGD:12793039
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	MAP2K1	IDA		Human	PMID:8388392
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	Map2k1	IMP		Rat	PMID:19029245\|RGD:8553977
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	Map2k1	IMP		Rat	PMID:18086894\|RGD:2292639
Biological Process	GO:0006468	protein phosphorylation	MAP2K1	IDA		Human	PMID:28166211
Biological Process	GO:0006468	protein phosphorylation	Map2k1	IMP		Mouse	PMID:15896720
Biological Process	GO:0006468	protein phosphorylation	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:19047410
Biological Process	GO:0006468	protein phosphorylation	Map2k1	IDA		Rat	PMID:7565670\|RGD:2293209
Biological Process	GO:0006468	protein phosphorylation	Map2k1	IDA		Rat	PMID:7611406\|RGD:2298674
Biological Process	GO:0006468	protein phosphorylation	Map2k1	IDA		Rat	PMID:8393135\|RGD:61657
Biological Process	GO:0048679	regulation of axon regeneration	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:24733831
Biological Process	GO:0048679	regulation of axon regeneration	Map2k1	IGI	MGI:MGI:88190	Mouse	PMID:24733831
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Map2k1	IDA		Rat	PMID:26581593\|RGD:12879823
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Map2k1	EXP		Rat	PMID:12202034\|RGD:13702166
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Map2k1	IDA		Rat	PMID:12202034\|RGD:13702166
Biological Process	GO:0003056	regulation of vascular associated smooth muscle contraction	Map2k1	IMP		Rat	PMID:10198244\|RGD:2293329
Biological Process	GO:0048678	response to axon injury	Map2k1	IMP		Rat	PMID:15737734\|RGD:2293210
Biological Process	GO:0051384	response to glucocorticoid	Map2k1	IDA		Rat	PMID:11872750\|RGD:625388
Biological Process	GO:0006979	response to oxidative stress	Map2k1	IDA		Rat	PMID:16481589\|RGD:1582172
Biological Process	GO:0048538	thymus development	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:18952847
Biological Process	GO:0030878	thyroid gland development	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:18952847
Biological Process	GO:0060440	trachea formation	Map2k1	IGI	MGI:MGI:1346867	Mouse	PMID:25100655
Biological Process	GO:0070328	triglyceride homeostasis	Map2k1	IDA		Rat	PMID:26581593\|RGD:12879823
Biological Process	GO:0044342	type B pancreatic cell proliferation	Map2k1	IMP		Mouse	PMID:18202127
Biological Process	GO:0047496	vesicle transport along microtubule	Map2k1	IDA		Rat	PMID:15753041\|RGD:2293208

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.