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Map2k1 Gene Detail
Summary
  • Symbol
    Map2k1
  • Name
    mitogen-activated protein kinase kinase 1
  • Synonyms
    MAP kinase kinase 1, Mek1, Prkmk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346866
    NCBI Gene: 26395
  • Gene Overview
    MyGene.info: MAP2K1
Location & Maps
more
  • Sequence Map
    Chr9:64185770-64253631 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      67862 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.55 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MAP2K1, mitogen-activated protein kinase kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP2K1, mitogen-activated protein kinase kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFC3, MAPKK1, MEK1, MKK1, PRKMK1
  • Links
    NCBI Gene ID: 5604
    neXtProt AC: NX_Q02750
    UniProt: Q02750

  • Chr Location
    15q22.31; chr15:66386873-66491544 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human MAP2K1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 12 genetic backgrounds
    49 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced embryo size and midgestational lethality due to impaired development and hypovascularization of the placenta with decreased labyrinth cell proliferation and enhanced cell apoptosis. Mutant MEFs fail to exhibit fibronectin-induced migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    112
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    178
  • Tissues
    149
  • cDNA Data
    16
  • Literature Summary
    37
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016895 VEGA Gene Model | MGI Sequence Detail 67862 C57BL/6J ±  kb
transcript OTTMUST00000040998 VEGA | MGI Sequence Detail 2436 Not Applicable  
polypeptide OTTMUSP00000018355 VEGA | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    402 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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Molecular
Reagents
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  • All nucleic 19
    cDNA 16
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-19441, MGD-MRK-19443, MGI:102562
References
more
  • Summaries
    All 159
    Developmental Gene Expression 37
    Gene Ontology 20
    Phenotypes 60
  • Earliest
    J:25190 Crews CM, et al., The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992 Oct 16;258(5081):478-80
  • Latest
    J:239814 Furusho M, et al., Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner. J Neurosci. 2017 Mar 15;37(11):2931-2946
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory