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Map2k1 Gene Detail
Summary
  • Symbol
    Map2k1
  • Name
    mitogen-activated protein kinase kinase 1
  • Synonyms
    MAP kinase kinase 1, Mek1, Prkmk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346866
    NCBI Gene: 26395
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64093066-64160887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.55 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2013 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346866
 protein coding gene Chr9:64093052-64160913 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034938
 protein coding gene Chr9:63831705-63909630 (-)
A/J MGP_AJ_G0034918
 protein coding gene Chr9:61703079-61772895 (-)
AKR/J MGP_AKRJ_G0034848
 protein coding gene Chr9:63135421-63205091 (-)
BALB/cJ MGP_BALBcJ_G0034911
 protein coding gene Chr9:61426268-61497691 (-)
C3H/HeJ MGP_C3HHeJ_G0034621
 protein coding gene Chr9:63664026-63735703 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035430
 protein coding gene Chr9:65568607-65644807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032341
 protein coding gene Chr9:61355657-61418673 (-)
CAST/EiJ MGP_CASTEiJ_G0033942
 protein coding gene Chr9:63825163-63896579 (-)
CBA/J MGP_CBAJ_G0034592
 protein coding gene Chr9:67834374-67899190 (-)
DBA/2J MGP_DBA2J_G0034751
 protein coding gene Chr9:61484790-61551900 (-)
FVB/NJ MGP_FVBNJ_G0034693
 protein coding gene Chr9:60787008-60854396 (-)
LP/J MGP_LPJ_G0034834
 protein coding gene Chr9:64123061-64191249 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034736
 protein coding gene Chr9:69131390-69205458 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035452
 protein coding gene Chr9:63243746-63313068 (-)
PWK/PhJ MGP_PWKPhJ_G0033646
 protein coding gene Chr9:61640133-61711057 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033480
 protein coding gene Chr9:63517100-63596211 (-)
WSB/EiJ MGP_WSBEiJ_G0034055
 protein coding gene Chr9:63142377-63211911 (-)



Homology
more
  • Human Ortholog
    MAP2K1, mitogen-activated protein kinase kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP2K1, mitogen-activated protein kinase kinase 1
  • Synonyms
    CFC3, MAPKK1, MEK1, MEL, MKK1, PRKMK1
  • Links
    NCBI Gene ID: 5604
    UniProt: Q02750

  • Chr Location
    15q22.31; chr15:66386837-66491656 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Map2k1 mouse models; 6 with human MAP2K1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 8 alleles in 14 genetic backgrounds
    41 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced embryo size and midgestational lethality due to impaired development and hypovascularization of the placenta with decreased labyrinth cell proliferation and enhanced cell apoptosis. Mutant MEFs fail to exhibit fibronectin-induced migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    207
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    189
  • cDNA Data
    18
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26395 NCBI Gene Model | MGI Sequence Detail 67822 C57BL/6J ±  kb
    transcript NM_008927 RefSeq | MGI Sequence Detail 2396 ZRU/MplStud  
    polypeptide P31938 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000010125 dual specificity mitogen-activated protein kinase kinase 1
      (term hierarchy)
    • EC
      2.7.12.2
    • InterPro Domains
      IPR050915 MAP kinase kinase
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      P31938 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 18
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19441, MGD-MRK-19443, MGI:102562
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 36
      Phenotypes 76
    • Earliest
      J:25190 Crews CM, et al., The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992 Oct 16;258(5081):478-80
    • Latest
      J:363161 Gao Y, et al., NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons. Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e2416757122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory