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Map2k1
Gene Detail
 Symbol
Name
ID
Map2k1
mitogen-activated protein kinase kinase 1
MGI:1346866
Synonyms MAP kinase kinase 1, Mek1, Prkmk1
Feature Type protein coding gene
Genetic Map
Chromosome 9
34.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:64185770-64253631 bp, - strand
From VEGA annotation of GRCm38

  67862 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k1

Human
homologs
Human Homolog MAP2K1, mitogen-activated protein kinase kinase 1
NCBI Gene ID 5604
neXtProt AC  NX_Q02750
Human Synonyms  CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Human Chr (Location)  15q22.1-q22.33; chr15:66386844-66491544 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAP2K1
Mutations,
alleles, and
phenotypes
All mutations/alleles(172) : Gene trapped(168) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to reduced embryo size and midgestational lethality due to impaired development and hypovascularization of the placenta with decreased labyrinth cell proliferation and enhanced cell apoptosis. Mutant MEFs fail to exhibit fibronectin-induced migration.
 
Interactions
Map2k1 interacts with 206 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process activation of MAPK activity, cell cycle arrest, ...
Component axon, cell cortex, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (178)    Tissues (149)    Images (40)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 41
RNA in situ 105
Northern blot 10
Western blot 18
RT-PCR 4
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016895 (Evidence)
Ensembl Gene ModelENSMUSG00000004936 (Evidence)
Entrez Gene26395 (Evidence)
DFCITC1572700
DoTSDT.87066573
NIA Mouse Gene IndexU030994
EC2.7.12.2
Consensus CDS ProjectCCDS23277.1
International Mouse Knockout Project StatusMap2k1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016895 VEGA Gene Model | MGI Sequence Detail 67862 C57BL/6J ±  kb
transcript OTTMUST00000040998 VEGA | MGI Sequence Detail 2436 Not Applicable 
polypeptide OTTMUSP00000018355 VEGA | MGI Sequence Detail 393 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010125 dual specificity mitogen-activated protein kinase kinase 1
References (Earliest) J:25190 Crews CM, et al., The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992 Oct 16;258(5081):478-80
(Latest) J:210997 Ihermann-Hella A, et al., Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet. 2014 Mar;10(3):e1004193
All references(113)
Other
accession IDs
MGD-MRK-19441, MGD-MRK-19443, MGI:102562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory