Map2k1
Gene Detail

Symbol Name ID

Map2k1 mitogen-activated protein kinase kinase 1 MGI:1346866

Synonyms

MAP kinase kinase 1, Mek1, Prkmk1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

34.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:64185770-64253631 bp, - strand From VEGA annotation of GRCm38   67862 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k1

Human homologs

Human Homolog		MAP2K1, mitogen-activated protein kinase kinase 1
NCBI Gene ID		5604
neXtProt AC		NX_Q02750
Human Synonyms		CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Human Chr (Location)		15q22.1-q22.33; chr15:66386844-66491544 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human MAP2K1

Alleles and phenotypes

All alleles(172) : Gene trapped(168) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene leads to reduced embryo size and midgestational lethality due to impaired development and hypovascularization of the placenta with decreased labyrinth cell proliferation and enhanced cell apoptosis. Mutant MEFs fail to exhibit fibronectin-induced migration.

 

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	activation of MAPK activity, cell cycle arrest, ...
Component	axon, cell cortex, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)

Data Summary: Results (181)    Tissues (151)    Images (40)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	41
RNA in situ	105
Northern blot	10
Western blot	18
RT-PCR	7

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016895 (Evidence)
Ensembl Gene Model	ENSMUSG00000004936 (Evidence)
Entrez Gene	26395 (Evidence)
DFCI	TC1572700
DoTS	DT.87066573
NIA Mouse Gene Index	U030994
EC	2.7.12.2
Consensus CDS Project	CCDS23277.1
International Mouse Knockout Project Status	Map2k1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016895	VEGA Gene Model | MGI Sequence Detail	67862	C57BL/6J
transcript	OTTMUST00000040998	VEGA | MGI Sequence Detail	2436	Not Applicable
polypeptide	OTTMUSP00000018355	VEGA | MGI Sequence Detail	393	Not Applicable

All sequences(51) RefSeq(6) UniProt(6)

Polymorphisms

RFLP(1) : SNPs within 2kb(402 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010125	dual specificity mitogen-activated protein kinase kinase 1

References

(Earliest) J:25190 Crews CM, et al., The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992 Oct 16;258(5081):478-80
(Latest) J:210622 Chen T, et al., Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. Cancer Cell. 2014 May 12;25(5):682-96
All references(111)

Other accession IDs

MGD-MRK-19441, MGD-MRK-19443, MGI:102562