Homozygous inactivation of this gene leads to reduced embryo size and midgestational lethality due to impaired development and hypovascularization of the placenta with decreased labyrinth cell proliferation and enhanced cell apoptosis. Mutant MEFs fail to exhibit fibronectin-induced migration.
|InterPro||IPR017441||Protein kinase, ATP binding site|
|InterPro||IPR000719||Protein kinase, catalytic domain|
|InterPro||IPR011009||Protein kinase-like domain|
|InterPro||IPR002290||Serine/threonine- / dual specificity protein kinase, catalytic domain|
|InterPro||IPR008271||Serine/threonine-protein kinase, active site|
|Protein Ontology||PR:000010125||dual specificity mitogen-activated protein kinase kinase 1|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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