Map2k1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map2k1
mitogen-activated protein kinase kinase 1
MGI:1346866

37 phenotypes from 8 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map2k1^em1(IMPC)H/Map2k1^em1(IMPC)H C57BL/6NTac-Map2k1^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Map2k1^{Gt(ROSABetageo)J2Chrn}/Map2k1^{Gt(ROSABetageo)J2Chrn} involves: 129/Sv * 129S/SvEv * C57BL/6J * SJL	abnormal angiogenesis	J:54197
	abnormal cell migration	J:54197
	abnormal placenta labyrinth morphology	J:54197
	abnormal placental labyrinth vasculature morphology	J:54197
	abnormal spongiotrophoblast layer morphology	J:54197
	abnormal vascular endothelial cell migration	J:54197
	decreased embryo size	J:54197
	embryo tissue necrosis	J:54197
	embryonic lethality during organogenesis, incomplete penetrance	J:54197
	pale yolk sac	J:54197
Map2k1^{Gt(ROSABetageo)J2Chrn}/Map2k1^{Gt(ROSABetageo)J2Chrn} involves: 129/Sv * C57BL/6J * SJL	abnormal placenta labyrinth morphology	J:112223
	abnormal placenta morphology	J:112223
	embryonic lethality during organogenesis, complete penetrance	J:112223
	small placenta	J:112223
Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc 129-Map2k1^tm1.1Bacc	embryonic lethality during organogenesis, complete penetrance	J:199705
Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc either: 129-Map2k1^tm1.1Bacc or (involves: 129P2/OlaHsd * C57BL/6)	abnormal trophoblast layer morphology	J:199705
	absent ectoplacental cone	J:199705
Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc involves: 129P2/OlaHsd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:199705
Map2k1^tm1.1Chrn/Map2k1^tm1.1Chrn involves: 129S/SvEv * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:112223
Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	no abnormal phenotype detected	J:199705
Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Meox2^tm1(cre)Sor/Meox2⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	normal mortality/aging	J:199705
Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	normal nervous system phenotype	J:199705
	postnatal growth retardation	J:199705
Map2k1^tm1Chrn/Map2k1^tm1.1Chrn Edil3^{Tg(Sox2-cre)1Amc}/? involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	normal reproductive system phenotype	J:112223
Map2k1^tm2.1Chrn/Map2k1⁺ involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	pulmonary artery stenosis	J:261678
Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	decreased cranium length	J:261678
	decreased cranium width	J:261678
	increased inner canthal distance	J:261678
	pulmonary artery stenosis	J:261678
Map2k1^tm2.1Chrn/Map2k1^tm2.1Chrn involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	increased astrocyte number	J:261678
	increased cranium length	J:261678
	increased oligodendrocyte number	J:261678
	pulmonary artery stenosis	J:261678
Tg(Myh6-Map2k1*)1Jmol/? involves: FVB	decreased cardiomyocyte apoptosis	J:66102
	decreased left ventricle diastolic pressure	J:66102
	heart left ventricle hypertrophy	J:66102
	increased heart weight	J:66102
	increased left ventricle systolic pressure	J:66102
	increased myocardial fiber size	J:66102
	thick ventricular wall	J:66102
Tg(Myh6-Map2k1*)1Jmol/? involves: FVB/N	abnormal cardiac output	J:127872
	decreased cardiomyocyte apoptosis	J:127872
	decreased myocardial infarct size	J:127872

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