Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MALT1
  • Mouse genes Malt1
  • Rat genes Malt1
  • Zfish genes malt1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Malt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	MALT1	IDA		Human	PMID:31133753
Molecular Function	GO:0042802	identical protein binding	MALT1	IPI	UniProtKB:Q9UDY8	Human	PMID:22158899
Molecular Function	GO:0019209	kinase activator activity	MALT1	IMP		Human	PMID:15125833
Molecular Function	GO:0008233	peptidase activity	MALT1	IDA		Human	PMID:18223652
Molecular Function	GO:0002020	protease binding	Malt1	IPI	UniProtKB:Q60769	Mouse	MGI:MGI:4943389|PMID:18223652
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9Y4K3	Human	PMID:15125833
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q13489	Human	PMID:16123224
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q13501	Human	PMID:16874300
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:17948050
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:P0CG48	Human	PMID:17948050
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9BXL7	Human	PMID:17948050
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9Y4K3	Human	PMID:17948050
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9Y6K9	Human	PMID:17948050
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:18223652
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:P21580	Human	PMID:18223652
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:19118383
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:P48729	Human	PMID:19118383
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:19444310
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:21157432
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:22267217
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q14790	Human	PMID:22267217
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:22528498
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9BXL7	Human	PMID:22528498
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9Y4K3	Human	PMID:22528498
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:27070702
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9H0F6	Human	PMID:27070702
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q9Y6K9	Human	PMID:27070702
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:O95999	Human	PMID:31774199
Molecular Function	GO:0005515	protein binding	MALT1	IPI	UniProtKB:Q96PU8	Human	PMID:31774199
Molecular Function	GO:0005515	protein binding	Malt1	IPI	PR:Q9Z0H7	Mouse	PMID:16495340
Molecular Function	GO:0043621	protein self-association	MALT1	IPI	UniProtKB:Q9UDY8	Human	PMID:15125833
Molecular Function	GO:0036094	small molecule binding	MALT1	EXP		Human	PMID:22366302
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	MALT1	IDA		Human	PMID:14695475
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	MALT1	IDA		Human	PMID:15125833
Cellular Component	GO:0032449	CBM complex	MALT1	IDA		Human	PMID:28628108
Cellular Component	GO:0005737	cytoplasm	MALT1	IDA		Human	PMID:16123224
Cellular Component	GO:0005829	cytosol	MALT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Malt1	IDA		Mouse	MGI:MGI:3694380|PMID:16831874
Cellular Component	GO:0001650	fibrillar center	MALT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	MALT1	IDA		Human	PMID:16123224
Cellular Component	GO:0002096	polkadots	Malt1	IDA		Mouse	MGI:MGI:3656456|PMID:16495340
Cellular Component	GO:0032991	protein-containing complex	MALT1	IDA		Human	PMID:15125833
Cellular Component	GO:0032991	protein-containing complex	MALT1	IDA		Human	PMID:22267217
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	MALT1	IMP		Human	PMID:15125833
Biological Process	GO:0042113	B cell activation	Malt1	IMP	MGI:MGI:2684761	Mouse	PMID:14576442
Biological Process	GO:0001923	B-1 B cell differentiation	Malt1	IMP	MGI:MGI:3639305	Mouse	PMID:14614861
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Malt1	IEP		Mouse	MGI:MGI:3694380|PMID:16831874
Biological Process	GO:0045087	innate immune response	Malt1	IEP		Mouse	MGI:MGI:3694380|PMID:16831874
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Malt1	IDA		Mouse	MGI:MGI:3694380|PMID:16831874
Biological Process	GO:0051168	nuclear export	MALT1	IDA		Human	PMID:16123224
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	MALT1	IMP		Human	PMID:22267217
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	MALT1	HMP		Human	PMID:12761501
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	MALT1	IMP		Human	PMID:22267217
Biological Process	GO:0032743	positive regulation of interleukin-2 production	MALT1	IMP		Human	PMID:15125833
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MALT1	IMP		Human	PMID:18223652
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Malt1	IMP	MGI:MGI:3639305	Mouse	PMID:14614861
Biological Process	GO:0050870	positive regulation of T cell activation	Malt1	IMP	MGI:MGI:3639305	Mouse	PMID:14614861
Biological Process	GO:0002726	positive regulation of T cell cytokine production	MALT1	IMP		Human	PMID:15125833
Biological Process	GO:2000321	positive regulation of T-helper 17 cell differentiation	Malt1	IDA		Mouse	MGI:MGI:6142401|PMID:25282160
Biological Process	GO:0006508	proteolysis	MALT1	IDA		Human	PMID:18223652
Biological Process	GO:0006508	proteolysis	Malt1	IDA		Mouse	MGI:MGI:6142401|PMID:25282160
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	MALT1	IDA		Human	PMID:31133753
Biological Process	GO:0042981	regulation of apoptotic process	MALT1	IDA		Human	PMID:12819136
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	Malt1	IMP	MGI:MGI:3639305	Mouse	PMID:14614861
Biological Process	GO:0009620	response to fungus	Malt1	IMP	MGI:MGI:3639305	Mouse	PMID:16862125
Biological Process	GO:0042098	T cell proliferation	Malt1	IMP	MGI:MGI:2684761	Mouse	PMID:14576442
Biological Process	GO:0050852	T cell receptor signaling pathway	MALT1	IDA		Human	PMID:15125833
Biological Process	GO:0050852	T cell receptor signaling pathway	Malt1	IDA		Mouse	MGI:MGI:6142401|PMID:25282160

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern