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Malt1
Gene Detail
 Symbol
Name
ID
Malt1
mucosa associated lymphoid tissue lymphoma translocation gene 1
MGI:2445027
Synonyms D430033E09Rik, paracaspase
Feature Type protein coding gene
Genetic Map
Chromosome 18
38.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:65430963-65478823 bp, + strand
From VEGA annotation of GRCm38

  47861 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mucosa-associated lymphoid tissue lymphoma translocation protein 1
Gene Tree: Malt1

Human
homologs
Human Homolog MALT1, mucosa associated lymphoid tissue lymphoma translocation gene 1
NCBI Gene ID 10892
neXtProt AC  NX_Q9UDY8
Human Synonyms  IMD12, MLT, MLT1
Human Chr (Location)  18q21; chr18:58671386-58750139 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MALT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene disrupts normal B cell development and leads to impaired cytokine production and T cell and B cell proliferative responses after antigen receptor engagement due to failure of NF-kappaB activation.
 
Interactions
Malt1 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process activation of NF-kappaB-inducing kinase activity, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function cysteine-type endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (70)    Tissues (10)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 70
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000014910 (Evidence)
Ensembl Gene ModelENSMUSG00000032688 (Evidence)
Entrez Gene240354 (Evidence)
UniGene132613
DFCITC1580837, TC1596346, TC1644537
DoTSDT.103565927, DT.60100513, DT.91317063, DT.91581418, DT.91598033
NIA Mouse Gene IndexU018825
EC3.4.22.-
PDB3V4L
Consensus CDS ProjectCCDS29306.1
International Mouse Knockout Project StatusMalt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014910 VEGA Gene Model | MGI Sequence Detail 47861 C57BL/6J ±  kb
transcript OTTMUST00000035418 VEGA | MGI Sequence Detail 5073 Not Applicable 
polypeptide OTTMUSP00000015838 VEGA | MGI Sequence Detail 821 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(231 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011029 Death-like domain
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
Protein Ontology PR:000010096 mucosa-associated lymphoid tissue lymphoma translocation protein 1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:198415 Uehata T, et al., Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Cell. 2013 May 23;153(5):1036-49
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory