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Malt1 Gene Detail
Summary
  • Symbol
    Malt1
  • Name
    MALT1 paracaspase
  • Synonyms
    D430033E09Rik, paracaspase, Pcasp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445027
    NCBI Gene: 240354
  • Gene Overview
    MyGene.info: MALT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:65430963-65478823 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47861 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 38.56 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MALT1, MALT1 paracaspase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MALT1, MALT1 paracaspase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD12, MLT, MLT1, PCASP1
  • Links
    NCBI Gene ID: 10892
    neXtProt AC: NX_Q9UDY8
    UniProt: Q9UDY8

  • Chr Location
    18q21.32; chr18:58671386-58753806 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    7 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene disrupts normal B cell development and leads to impaired cytokine production and T cell and B cell proliferative responses after antigen receptor engagement due to failure of NF-kappaB activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014910 VEGA Gene Model | MGI Sequence Detail 47861 C57BL/6J ±  kb
    transcript OTTMUST00000035418 VEGA | MGI Sequence Detail 5073 Not Applicable  
    polypeptide OTTMUSP00000015838 VEGA | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      231 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44

      Microarray probesets 2
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
    • Latest
      J:259861 Brustle A, et al., MALT1 is an intrinsic regulator of regulatory T cells. Cell Death Differ. 2017 Jul;24(7):1214-1223

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory