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Malt1 Gene Detail
Summary
  • Symbol
    Malt1
  • Name
    MALT1 paracaspase
  • Synonyms
    D430033E09Rik, paracaspase, Pcasp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445027
    NCBI Gene: 240354
  • Gene Overview
    MyGene.info: MALT1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:65430962-65478823 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 38.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445027
protein coding gene Chr18:65430962-65478888 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024508
protein coding gene Chr18:65564672-65614340 (+)
A/J MGP_AJ_G0024475
protein coding gene Chr18:62722762-62770569 (+)
AKR/J MGP_AKRJ_G0024445
protein coding gene Chr18:64493258-64540952 (+)
BALB/cJ MGP_BALBcJ_G0024474
protein coding gene Chr18:62862314-62910618 (+)
C3H/HeJ MGP_C3HHeJ_G0024242
protein coding gene Chr18:64687444-64740064 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024921
protein coding gene Chr18:67319113-67368314 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022352
protein coding gene Chr18:62158737-62208656 (+)
CAST/EiJ MGP_CASTEiJ_G0023715
protein coding gene Chr18:64663995-64715636 (+)
CBA/J MGP_CBAJ_G0024212
protein coding gene Chr18:69515140-69567768 (+)
DBA/2J MGP_DBA2J_G0024342
protein coding gene Chr18:62375699-62425608 (+)
FVB/NJ MGP_FVBNJ_G0024308
protein coding gene Chr18:61770247-61817998 (+)
LP/J MGP_LPJ_G0024426
protein coding gene Chr18:65419890-65471029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024337
protein coding gene Chr18:70944089-70996472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024968
protein coding gene Chr18:64702136-64750627 (+)
PWK/PhJ MGP_PWKPhJ_G0023458
protein coding gene Chr18:62631318-62680520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023263
protein coding gene Chr18:64849120-64899617 (+)
WSB/EiJ MGP_WSBEiJ_G0023779
protein coding gene Chr18:64554557-64604585 (+)



Homology
more
  • Human Ortholog
    MALT1, MALT1 paracaspase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MALT1, MALT1 paracaspase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD12, MLT, MLT1, PCASP1
  • Links
    NCBI Gene ID: 10892
    neXtProt AC: NX_Q9UDY8
    UniProt: Q9UDY8

  • Chr Location
    18q21.32; chr18:58671386-58753806 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    7 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene disrupts normal B cell development and leads to impaired cytokine production and T cell and B cell proliferative responses after antigen receptor engagement due to failure of NF-kappaB activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032688 Ensembl Gene Model | MGI Sequence Detail 47862 C57BL/6J ±  kb
    transcript ENSMUST00000224056 Ensembl | MGI Sequence Detail 4028 Not Applicable  
    polypeptide ENSMUSP00000153585 Ensembl | MGI Sequence Detail 832 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 2
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 13
      Phenotypes 39
    • Earliest
      J:71748 McAllister-Lucas LM, et al., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem. 2001 Aug 17;276(33):30589-97
    • Latest
      J:265022 Kip E, et al., MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain. J Virol. 2018 Apr 15;92(8)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory