Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LTA
  • Mouse genes Lta
  • Rat genes Lta
  • Zfish genes lta,tnfa,tnfb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lta

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LTA	IPI	UniProtKB:O95870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTA	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTA	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LTA	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Lta	IPI	PR:Q8BMS2	Mouse	PMID:14691481
Cellular Component	GO:0005615	extracellular space	Lta	IDA		Rat	PMID:1080770|RGD:1581946
Cellular Component	GO:0005615	extracellular space	tnfa	IMP		Zfish	PMID:25416946
Biological Process	GO:0006914	autophagy	tnfa	IMP	ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:27351838
Biological Process	GO:0042742	defense response to bacterium	tnfa	IDA		Zfish	PMID:29572872
Biological Process	GO:0042742	defense response to bacterium	tnfb	IDA		Zfish	PMID:29572872
Biological Process	GO:0042742	defense response to bacterium	tnfa	IDA		Zfish	PMID:19047404
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Lta	IGI	MGI:MGI:104798	Mouse	PMID:9834074
Biological Process	GO:0031101	fin regeneration	tnfa	IMP	ZFIN:ZDB-MRPHLNO-171010-5	Zfish	PMID:28796253
Biological Process	GO:0006959	humoral immune response	Lta	IMP	MGI:MGI:1860957	Mouse	PMID:7636227
Biological Process	GO:0006955	immune response	tnfb	IDA		Zfish	PMID:29572872
Biological Process	GO:0006955	immune response	tnfa	IDA		Zfish	PMID:29572872
Biological Process	GO:0006955	immune response	tnfa	IDA		Zfish	PMID:15752547
Biological Process	GO:0006954	inflammatory response	tnfa	IGI	ZFIN:ZDB-GENO-150617-6,ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:25730872
Biological Process	GO:0060729	intestinal epithelial structure maintenance	tnfa	IGI	ZFIN:ZDB-GENO-150617-6,ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:25730872
Biological Process	GO:0001889	liver development	tnfa	IMP	ZFIN:ZDB-MRPHLNO-171212-1	Zfish	PMID:27366683
Biological Process	GO:0001889	liver development	tnfa	IMP	ZFIN:ZDB-MRPHLNO-110301-5	Zfish	PMID:21064033
Biological Process	GO:0001889	liver development	tnfb	IMP	ZFIN:ZDB-MRPHLNO-110301-6	Zfish	PMID:21064033
Biological Process	GO:0048535	lymph node development	Lta	IMP	MGI:MGI:1860954	Mouse	PMID:9565643
Biological Process	GO:0048535	lymph node development	Lta	IMP	MGI:MGI:1860957	Mouse	PMID:7636227
Biological Process	GO:0048535	lymph node development	Lta	IMP		Mouse	PMID:10415063
Biological Process	GO:0048535	lymph node development	Lta	IMP	MGI:MGI:1860953	Mouse	PMID:9368616
Biological Process	GO:0048535	lymph node development	Lta	IMP	MGI:MGI:1857215	Mouse	PMID:8171322
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Lta	IDA		Rat	PMID:1080770|RGD:1581946
Biological Process	GO:0038061	NIK/NF-kappaB signaling	tnfa	IMP		Zfish	PMID:25416946
Biological Process	GO:0032292	peripheral nervous system axon ensheathment	tnfa	IMP	ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:28379965
Biological Process	GO:0043065	positive regulation of apoptotic process	Lta	IMP		Rat	PMID:9798700|RGD:1580413
Biological Process	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	Lta	IGI	MGI:MGI:104798	Mouse	PMID:9834074
Biological Process	GO:0060252	positive regulation of glial cell proliferation	Lta	IMP		Rat	PMID:11595667|RGD:8548857
Biological Process	GO:1902038	positive regulation of hematopoietic stem cell differentiation	tnfa	IMP	ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:25416946
Biological Process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	Lta	IGI	MGI:MGI:104798	Mouse	PMID:9834074
Biological Process	GO:0032729	positive regulation of type II interferon production	Lta	IGI	MGI:MGI:104798	Mouse	PMID:9834074
Biological Process	GO:0070207	protein homotrimerization	tnfa	IPI	UniProtKB:Q6T9C7	Zfish	PMID:33989682
Biological Process	GO:0031099	regeneration	tnfa	IMP	ZFIN:ZDB-MRPHLNO-090428-3	Zfish	PMID:23575850
Biological Process	GO:0046685	response to arsenic-containing substance	tnfa	IDA		Zfish	PMID:17400579
Biological Process	GO:0046685	response to arsenic-containing substance	tnfa	IDA		Zfish	PMID:16007375
Biological Process	GO:0009617	response to bacterium	tnfa	IDA		Zfish	PMID:17400579
Biological Process	GO:0009617	response to bacterium	tnfa	IDA		Zfish	PMID:17804254
Biological Process	GO:0043330	response to exogenous dsRNA	tnfa	IDA		Zfish	PMID:19201835
Biological Process	GO:0043330	response to exogenous dsRNA	lta	IDA		Zfish	PMID:19201835
Biological Process	GO:0001666	response to hypoxia	Lta	IEP		Rat	PMID:15197744|RGD:4143218
Biological Process	GO:0032496	response to lipopolysaccharide	Lta	IEP		Rat	PMID:12849708|RGD:1625037
Biological Process	GO:0032496	response to lipopolysaccharide	tnfa	IDA		Zfish	PMID:19201835
Biological Process	GO:0032496	response to lipopolysaccharide	tnfa	IDA		Zfish	PMID:17442590
Biological Process	GO:0032496	response to lipopolysaccharide	lta	IDA		Zfish	PMID:19201835
Biological Process	GO:0002237	response to molecule of bacterial origin	tnfa	IDA		Zfish	PMID:19201835
Biological Process	GO:0002237	response to molecule of bacterial origin	lta	IDA		Zfish	PMID:19201835
Biological Process	GO:0007584	response to nutrient	Lta	IEP		Rat	PMID:12122042|RGD:628312
Biological Process	GO:0009615	response to virus	tnfa	IMP	ZFIN:ZDB-MRPHLNO-110621-1	Zfish	PMID:27351838
Biological Process	GO:0009615	response to virus	tnfa	IDA		Zfish	PMID:25746990
Biological Process	GO:0009615	response to virus	tnfa	IDA		Zfish	PMID:17371995
Biological Process	GO:0009615	response to virus	tnfa	IDA		Zfish	PMID:16007375
Biological Process	GO:0009410	response to xenobiotic stimulus	Lta	IEP		Rat	PMID:20298761|RGD:4143212
Biological Process	GO:0032609	type II interferon production	Lta	IGI	MGI:MGI:104798	Mouse	PMID:9834074

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern