Lta
Gene Detail

Symbol Name ID

Lta lymphotoxin A MGI:104797

STS

D17Mit13, D17Nds3

Synonyms

hlb382, LT, LT-[a], LT[a], LTalpha, LT-alpha, Ltx, lymphotoxin, lymphotoxin alpha, Tnfb, TNF beta, TNF-beta, Tnfsf1b

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr17:35203165-35205351 bp, - strand From VEGA annotation of GRCm38   2187 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Lta

Human homologs

Human Homolog		LTA, lymphotoxin alpha (TNF superfamily, member 1)
NCBI Gene ID		4049
neXtProt AC		NX_P01374
Human Synonyms		LT, TNFB, TNFSF1
Human Chr (Location)		6p21.3; chr6:31539876-31542101 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human LTA

Alleles and phenotypes

All alleles(10) : Targeted(9) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit absence of lymph nodes, Peyer's patches, and splenic germinal centers, impaired class switching and NK cell recruitment, and greater susceptibility to Mycobacterium bovis, influenza A, and Toxoplasma gondii.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell proliferation, cellular process, ...
Component	extracellular region, extracellular space, ...
Function	cytokine activity, tumor necrosis factor receptor binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (81)    Tissues (47)    Images (1)
Theiler Stages: 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	81

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) Genomic(42) cDNA(7) Primer pair(8) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037197 (Evidence)
Ensembl Gene Model	ENSMUSG00000024402 (Evidence)
Entrez Gene	16992 (Evidence)
UniGene	87787
DFCI	TC1586374
DoTS	DT.101331321, DT.527003, DT.91561134
NIA Mouse Gene Index	U037745
Consensus CDS Project	CCDS28692.1
International Mouse Knockout Project Status	Lta

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037197	VEGA Gene Model | MGI Sequence Detail	2187	C57BL/6J
transcript	OTTMUST00000095890	VEGA | MGI Sequence Detail	1383	Not Applicable
polypeptide	OTTMUSP00000053531	VEGA | MGI Sequence Detail	202	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

PCR(5) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR006053	Tumour necrosis factor alpha/beta/c
InterPro	IPR002960	Tumour necrosis factor beta/lymphotoxin alpha
InterPro	IPR021184	Tumour necrosis factor, conserved site
InterPro	IPR008983	Tumour necrosis factor-like
Protein Ontology	PR:000002204	lymphotoxin-alpha

References

(Earliest) J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
(Latest) J:193029 Chen X, et al., TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J Immunol. 2013 Feb 1;190(3):1076-84
All references(346)

Other accession IDs

MGD-MRK-11928, MGD-MRK-15153, MGD-MRK-28089, MGI:3575121