About   Help   FAQ
Lta Gene Detail
Summary
  • Symbol
    Lta
  • Name
    lymphotoxin A
  • Synonyms
    hlb382, LT, LT-[a], LT[a], LTalpha, LT-alpha, Ltx, lymphotoxin, lymphotoxin alpha, Tnfb, TNF beta, TNF-beta, Tnfsf1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104797
    NCBI Gene: 16992
  • Gene Overview
    MyGene.info: LTA
Location & Maps
more
  • Sequence Map
    Chr17:35203165-35205351 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2187 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LTA, lymphotoxin alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LTA, lymphotoxin alpha
    Orthology source: HomoloGene
  • Synonyms
    LT, TNFB, TNFSF1, TNLG1E
  • Links
    NCBI Gene ID: 4049
    neXtProt AC: NX_P01374

  • Chr Location
    6p21.3; chr6:31560550-31574324 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human LTA associations

Human Disease Mouse Models
       Leprosy, Susceptibility to, 4; LPRS4   OMIM: 610988
Myocardial Infarction, Susceptibility to   OMIM: 608446
Psoriatic Arthritis, Susceptibility to Psoriatic Arthritis, Susceptibility to, 1; PSORAS1   OMIM: 607507
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    87 phenotypes from 11 alleles in 22 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    265 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Targeted
    11
  • Transgenic
    3
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit absence of lymph nodes, Peyer's patches, and splenic germinal centers, impaired class switching and NK cell recruitment, and greater susceptibility to Mycobacterium bovis, influenza A, and Toxoplasma gondii.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037197 VEGA Gene Model | MGI Sequence Detail 2187 C57BL/6J ±  kb
transcript OTTMUST00000095890 VEGA | MGI Sequence Detail 1383 Not Applicable  
polypeptide OTTMUSP00000053531 VEGA | MGI Sequence Detail 202 Not Applicable  
For the selected sequence
Polymorphisms
less
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    Genomic 42
    cDNA 7
    Primer pair 8
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11928, MGD-MRK-15153, MGD-MRK-28089, MGI:3575121
References
more
  • Summaries
    All 362
    Developmental Gene Expression 10
    Gene Ontology 13
    Phenotypes 265
  • Earliest
    J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
  • Latest
    J:229710 Jones DD, et al., The omentum is a site of protective IgM production during intracellular bacterial infection. Infect Immun. 2015 May;83(5):2139-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory