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Lta Gene Detail
Summary
  • Symbol
    Lta
  • Name
    lymphotoxin A
  • Synonyms
    hlb382, LT, LT-[a], LT[a], LTalpha, LT-alpha, Ltx, lymphotoxin, lymphotoxin alpha, Tnfb, TNF beta, TNF-beta, Tnfsf1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104797
    NCBI Gene: 16992
  • Gene Overview
    MyGene.info: LTA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:35203165-35205351 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    28 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    LTA, lymphotoxin alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LTA, lymphotoxin alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LT, TNFB, TNFSF1, TNLG1E
  • Links
    NCBI Gene ID: 4049
    neXtProt AC: NX_P01374
    UniProt: P01374

  • Chr Location
    6p21.33; chr6:31560550-31574324 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human LTA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    91 phenotypes from 11 alleles in 22 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    270 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit absence of lymph nodes, Peyer's patches, and splenic germinal centers, impaired class switching and NK cell recruitment, and greater susceptibility to Mycobacterium bovis, influenza A, and Toxoplasma gondii.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037197 VEGA Gene Model | MGI Sequence Detail 2187 C57BL/6J ±  kb
    transcript OTTMUST00000095890 VEGA | MGI Sequence Detail 1383 Not Applicable  
    polypeptide OTTMUSP00000053531 VEGA | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 42
      cDNA 7
      Primer pair 8
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
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    MGD-MRK-11928, MGD-MRK-15153, MGD-MRK-28089, MGI:3575121
    References
    more
    • Summaries
      All 383
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 270
    • Earliest
      J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
    • Latest
      J:249558 Liu Z, et al., L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017 May 12;8(None):15196

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory