About   Help   FAQ
Lta
Gene Detail
 Symbol
Name
ID
Lta
lymphotoxin A
MGI:104797
STS D17Mit13, D17Nds3
Synonyms hlb382, LT, LT-[a], LT[a], LTalpha, LT-alpha, Ltx, lymphotoxin, lymphotoxin alpha, Tnfb, TNF beta, TNF-beta, Tnfsf1b
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr17:35203165-35205351 bp, - strand
From VEGA annotation of GRCm38

  2187 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Lta

Human
homologs
Human Homolog LTA, lymphotoxin alpha
NCBI Gene ID 4049
neXtProt AC  NX_P01374
Human Synonyms  LT, TNFB, TNFSF1
Human Chr (Location)  6p21.3; chr6:31572099-31574324 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human LTA
Alleles
and
phenotypes
All alleles(11) : Targeted(10) Chemically induced(1)
 
Homozygotes for targeted null mutations exhibit absence of lymph nodes, Peyer's patches, and splenic germinal centers, impaired class switching and NK cell recruitment, and greater susceptibility to Mycobacterium bovis, influenza A, and Toxoplasma gondii.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell proliferation, cellular process, ...
Component extracellular region, extracellular space, ...
Function cytokine activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (81)    Tissues (47)    Images (1)
Theiler Stages: 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 81
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(58) Genomic(42) cDNA(7) Primer pair(8) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037197 (Evidence)
Ensembl Gene ModelENSMUSG00000024402 (Evidence)
Entrez Gene16992 (Evidence)
UniGene87787
DFCITC1586374
DoTSDT.101331321, DT.527003, DT.91561134
NIA Mouse Gene IndexU037745
Consensus CDS ProjectCCDS28692.1
International Mouse Knockout Project StatusLta
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037197 VEGA Gene Model | MGI Sequence Detail 2187 C57BL/6J ±  kb
transcript OTTMUST00000095890 VEGA | MGI Sequence Detail 1383 Not Applicable 
polypeptide OTTMUSP00000053531 VEGA | MGI Sequence Detail 202 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(3)
Polymorphisms PCR(5) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR002960 Tumour necrosis factor beta/lymphotoxin alpha
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002204 lymphotoxin-alpha
References (Earliest) J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
(Latest) J:205784 Vander Lugt B, et al., CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes. J Immunol. 2013 Sep 15;191(6):3119-27
All references(353)
Other
accession IDs
MGD-MRK-11928, MGD-MRK-15153, MGD-MRK-28089, MGI:3575121

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory