Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRP1
  • Mouse genes Lrp1
  • Rat genes Lrp1
  • Zfish genes lrp1aa,lrp1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016964	alpha-2 macroglobulin receptor activity	LRP1	IMP		Human	PMID:26142438
Molecular Function	GO:0034185	apolipoprotein binding	LRP1	IPI	UniProtKB:Q6Q788	Human	PMID:18635818
Molecular Function	GO:0034185	apolipoprotein binding	LRP1	IDA		Human	PMID:2779654
Molecular Function	GO:0005509	calcium ion binding	Lrp1	IDA		Mouse	MGI:MGI:77596|PMID:3266596
Molecular Function	GO:0038024	cargo receptor activity	LRP1	IMP		Human	PMID:23152628
Molecular Function	GO:0038024	cargo receptor activity	LRP1	IMP		Human	PMID:24305823
Molecular Function	GO:0038024	cargo receptor activity	Lrp1	IMP		Mouse	MGI:MGI:5897551|PMID:21289173
Molecular Function	GO:0032050	clathrin heavy chain binding	LRP1	IPI	UniProtKB:Q00610	Human	PMID:26005850
Molecular Function	GO:0015026	coreceptor activity	Lrp1	IDA		Rat	PMID:18321860|RGD:13800554
Molecular Function	GO:0002020	protease binding	Lrp1	IPI	RGD:620196	Rat	PMID:10514495|RGD:2298533
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P21741	Human	PMID:10772929
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P02649	Human	PMID:15182176
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P30533	Human	PMID:17326667
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:Q6Q788	Human	PMID:17326667
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P78352	Human	PMID:17360663
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:Q12879	Human	PMID:17360663
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P02649	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P30533	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:Q03350	Human	PMID:20472562
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:Q63722	Human	PMID:20472562
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P11226	Human	PMID:21054788
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:Q15485	Human	PMID:21054788
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:O00213	Human	PMID:21968187
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:O00213	Human	PMID:24284412
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:O95782|UniProtKB:Q00610|UniProtKB:Q13492	Human	PMID:26005850
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P30533	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:Q92685	Human	PMID:29547901
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P00734	Human	PMID:8626514
Molecular Function	GO:0005515	protein binding	LRP1	IPI	UniProtKB:P05121	Human	PMID:8626514
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:Q3UBG2	Mouse	MGI:MGI:5306561|PMID:20205790
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:3687813|PMID:10827173
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:Q8C142	Mouse	MGI:MGI:3762243|PMID:17727637
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:P21741	Mouse	MGI:MGI:6294421|PMID:10772929
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:4359331|PMID:19455133
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:P97318|UniProtKB:Q9ERE9|UniProtKB:Q9WVI9	Mouse	MGI:MGI:3687813|PMID:10827173
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:P48356	Mouse	MGI:MGI:4944032|PMID:21264353
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:6092779|PMID:28671696
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	PR:O88307	Mouse	PMID:19047013
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	PR:Q6GQT1	Mouse	PMID:17920016
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:O95704	Rat	PMID:12153398|RGD:40902963
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	RGD:736468	Rat	PMID:16303771|RGD:1581914
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	UniProtKB:P00750	Rat	PMID:16303771|RGD:1581914
Molecular Function	GO:0005515	protein binding	Lrp1	IPI	RGD:3035	Rat	PMID:23132925|RGD:9685231
Molecular Function	GO:0044877	protein-containing complex binding	LRP1	IDA		Human	PMID:8626514
Molecular Function	GO:0003723	RNA binding	LRP1	HDA		Human	PMID:22658674
Molecular Function	GO:0005102	signaling receptor binding	Lrp1	IPI	UniProtKB:Q64729	Mouse	MGI:MGI:6434720|PMID:31023188
Cellular Component	GO:0045177	apical part of cell	Lrp1	IDA		Rat	PMID:20488202|RGD:13800549
Cellular Component	GO:0044295	axonal growth cone	Lrp1	IDA		Rat	PMID:26598525|RGD:11097297
Cellular Component	GO:0016323	basolateral plasma membrane	LRP1	IDA		Human	PMID:26005850
Cellular Component	GO:0030136	clathrin-coated vesicle	Lrp1	IDA		Rat	PMID:16190982|RGD:1581917
Cellular Component	GO:0030425	dendrite	Lrp1	IDA		Rat	PMID:9046007|RGD:1625032
Cellular Component	GO:0005769	early endosome	LRP1	IDA		Human	PMID:26005850
Cellular Component	GO:0005768	endosome	Lrp1	IDA		Rat	PMID:14701798|RGD:1625029
Cellular Component	GO:0009897	external side of plasma membrane	Lrp1	IDA		Mouse	PMID:19299737
Cellular Component	GO:0005925	focal adhesion	LRP1	HDA		Human	PMID:21423176
Cellular Component	GO:0032593	insulin-responsive compartment	Lrp1	IDA		Rat	PMID:19864425|RGD:13800551
Cellular Component	GO:0005765	lysosomal membrane	LRP1	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	Lrp1	IDA		Mouse	PMID:15082773
Cellular Component	GO:0043025	neuronal cell body	Lrp1	IDA		Rat	PMID:9046007|RGD:1625032
Cellular Component	GO:0005886	plasma membrane	Lrp1	IDA		Mouse	MGI:MGI:77596|PMID:3266596
Cellular Component	GO:0043235	receptor complex	LRP1	IDA		Human	PMID:23382219
Biological Process	GO:0097242	amyloid-beta clearance	Lrp1	IMP		Mouse	MGI:MGI:5437434|PMID:19098903
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	LRP1	IMP		Human	PMID:23152628
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	LRP1	IMP		Human	PMID:24305823
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Lrp1	IMP		Mouse	MGI:MGI:5465209|PMID:23152628
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Lrp1	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5529723|PMID:24305823
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Lrp1	IDA		Mouse	MGI:MGI:5897551|PMID:21289173
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	LRP1	IGI	UniProtKB:Q13492	Human	PMID:26005850
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	Lrp1	IDA		Mouse	MGI:MGI:5439721|PMID:20630619
Biological Process	GO:0035909	aorta morphogenesis	Lrp1	IMP		Mouse	MGI:MGI:4365879|PMID:19742316
Biological Process	GO:0043277	apoptotic cell clearance	Lrp1	IMP		Mouse	PMID:15647754
Biological Process	GO:0002265	astrocyte activation involved in immune response	Lrp1	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5465209|PMID:23152628
Biological Process	GO:0003279	cardiac septum development	Lrp1	IMP		Mouse	PMID:25807483
Biological Process	GO:0008283	cell population proliferation	Lrp1	IMP		Rat	PMID:15178744|RGD:1581918
Biological Process	GO:0044242	cellular lipid catabolic process	Lrp1	IMP		Rat	PMID:26506094|RGD:11251109
Biological Process	GO:1904646	cellular response to amyloid-beta	Lrp1	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5465209|PMID:23152628
Biological Process	GO:0021987	cerebral cortex development	Lrp1	IEP		Rat	PMID:8930375|RGD:10046019
Biological Process	GO:0061642	chemoattraction of axon	Lrp1	IMP		Rat	PMID:26598525|RGD:11097297
Biological Process	GO:0008203	cholesterol metabolic process	Lrp1	IMP	MGI:MGI:2177650,MGI:MGI:2180880	Mouse	PMID:17920016
Biological Process	GO:0060976	coronary vasculature development	Lrp1	IMP		Mouse	PMID:25807483
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Lrp1	IMP		Mouse	MGI:MGI:6434720|PMID:31023188
Biological Process	GO:0007041	lysosomal transport	Lrp1	IDA		Mouse	MGI:MGI:5701557|PMID:26370502
Biological Process	GO:0043066	negative regulation of apoptotic process	Lrp1	IMP		Rat	PMID:17065459|RGD:13800562
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	Lrp1	IMP		Rat	PMID:20197276|RGD:13800550
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Lrp1	IMP		Rat	PMID:22674573|RGD:13800523
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	Lrp1	IMP		Rat	PMID:20197276|RGD:13800550
Biological Process	GO:0010629	negative regulation of gene expression	Lrp1	IMP		Mouse	MGI:MGI:6434720|PMID:31023188
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Lrp1	IMP		Rat	PMID:17314289|RGD:1625020
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Lrp1	IDA		Rat	PMID:24086544|RGD:13800518
Biological Process	GO:0010977	negative regulation of neuron projection development	Lrp1	IMP		Rat	PMID:23132925|RGD:9685231
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	Lrp1	IMP		Mouse	MGI:MGI:6434720|PMID:31023188
Biological Process	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	Lrp1	IMP		Mouse	MGI:MGI:4365879|PMID:19742316
Biological Process	GO:0060392	negative regulation of SMAD protein signal transduction	Lrp1	IMP		Mouse	MGI:MGI:6434720|PMID:31023188
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	Lrp1	IMP		Mouse	MGI:MGI:4365879|PMID:19742316
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Lrp1	IGI	UniProtKB:P01137	Mouse	MGI:MGI:6434720|PMID:31023188
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Lrp1	IDA		Mouse	PMID:16207730
Biological Process	GO:0006909	phagocytosis	LRP1	IMP		Human	PMID:23152628
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Lrp1	IMP		Mouse	MGI:MGI:5754651|PMID:26619118
Biological Process	GO:0045773	positive regulation of axon extension	Lrp1	IMP		Rat	PMID:21040802|RGD:6904146
Biological Process	GO:0048691	positive regulation of axon extension involved in regeneration	Lrp1	IDA		Rat	PMID:23867460|RGD:13800520
Biological Process	GO:0010942	positive regulation of cell death	LRP1	IGI	ComplexPortal:CPX-1134,UniProtKB:P04925,UniProtKB:P30533	Human	PMID:23386614
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Lrp1	IMP		Rat	PMID:21290408|RGD:13800525
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Lrp1	IMP		Mouse	MGI:MGI:4358638|PMID:19718435
Biological Process	GO:1904109	positive regulation of cholesterol import	Lrp1	IMP		Rat	PMID:22454363|RGD:13800524
Biological Process	GO:0032376	positive regulation of cholesterol transport	Lrp1	IDA		Mouse	MGI:MGI:4358638|PMID:19718435
Biological Process	GO:0048694	positive regulation of collateral sprouting of injured axon	Lrp1	IDA		Rat	PMID:23867460|RGD:13800520
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Lrp1	IMP		Rat	PMID:18321860|RGD:13800554
Biological Process	GO:0045807	positive regulation of endocytosis	LRP1	IGI	UniProtKB:P04925	Human	PMID:23386614
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Lrp1	IMP		Rat	PMID:24865476|RGD:13800516
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Lrp1	IMP		Rat	PMID:24865476|RGD:13800516
Biological Process	GO:0032370	positive regulation of lipid transport	Lrp1	IMP		Mouse	MGI:MGI:4358638|PMID:19718435
Biological Process	GO:1905167	positive regulation of lysosomal protein catabolic process	LRP1	IMP		Human	PMID:23152628
Biological Process	GO:0010976	positive regulation of neuron projection development	Lrp1	IMP		Rat	PMID:24086544|RGD:13800518
Biological Process	GO:0050766	positive regulation of phagocytosis	Lrp1	IMP		Rat	PMID:19299462|RGD:13800552
Biological Process	GO:0032092	positive regulation of protein binding	LRP1	IGI	UniProtKB:P04925	Human	PMID:23386614
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	LRP1	IGI	UniProtKB:P04925	Human	PMID:23386614
Biological Process	GO:0051222	positive regulation of protein transport	Lrp1	IMP		Rat	PMID:11100124|RGD:1625016
Biological Process	GO:1900149	positive regulation of Schwann cell migration	Lrp1	IMP		Rat	PMID:20197276|RGD:13800550
Biological Process	GO:1904300	positive regulation of transcytosis	Lrp1	IMP		Mouse	MGI:MGI:5754651|PMID:26619118
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	Lrp1	IMP		Rat	PMID:20940000|RGD:13800527
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Lrp1	IMP		Rat	PMID:17314289|RGD:1625020
Biological Process	GO:0006898	receptor-mediated endocytosis	LRP1	IMP		Human	PMID:23152628
Biological Process	GO:0006898	receptor-mediated endocytosis	LRP1	IMP		Human	PMID:24305823
Biological Process	GO:0006898	receptor-mediated endocytosis	LRP1	IMP		Human	PMID:26005850
Biological Process	GO:0006898	receptor-mediated endocytosis	LRP1	IMP		Human	PMID:26781079
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp1	IMP		Mouse	MGI:MGI:5897551|PMID:21289173
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp1	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5529723|PMID:24305823
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp1	IGI	UniProtKB:Q05793	Mouse	MGI:MGI:5897551|PMID:21289173
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp1	IDA		Mouse	PMID:21795536
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp1	IMP		Rat	PMID:18285446|RGD:13800558
Biological Process	GO:0006898	receptor-mediated endocytosis	Lrp1	IMP		Rat	PMID:8626514|RGD:8554276
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Lrp1	IMP		Mouse	MGI:MGI:4365879|PMID:19742316
Biological Process	GO:0032374	regulation of cholesterol transport	Lrp1	IMP		Mouse	MGI:MGI:4358638|PMID:19718435
Biological Process	GO:0032429	regulation of phospholipase A2 activity	Lrp1	IMP		Mouse	MGI:MGI:4358638|PMID:19718435
Biological Process	GO:1905109	regulation of pulmonary blood vessel remodeling	Lrp1	IMP		Mouse	MGI:MGI:6434720|PMID:31023188
Biological Process	GO:1901342	regulation of vasculature development	lrp1ab	IMP	ZFIN:ZDB-MRPHLNO-130222-1	Zfish	PMID:22777006
Biological Process	GO:1901342	regulation of vasculature development	lrp1aa	IMP	ZFIN:ZDB-MRPHLNO-130222-3	Zfish	PMID:22777006
Biological Process	GO:1901342	regulation of vasculature development	lrp1aa	IMP	ZFIN:ZDB-MRPHLNO-130222-2	Zfish	PMID:22777006
Biological Process	GO:0150104	transport across blood-brain barrier	Lrp1	IMP		Mouse	MGI:MGI:5754651|PMID:26619118
Biological Process	GO:0150104	transport across blood-brain barrier	Lrp1	IMP		Mouse	MGI:MGI:5439721|PMID:20630619

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern