Lrp1
Gene Detail

Symbol Name ID

Lrp1 low density lipoprotein receptor-related protein 1 MGI:96828

Synonyms

A2mr, CD91

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.52 cM, cytoband B2-D1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr10:127538161-127621148 bp, - strand From VEGA annotation of GRCm38   82988 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: LDL receptor-related protein
Gene Tree: Lrp1

Human homologs

Human Homolog		LRP1, low density lipoprotein receptor-related protein 1
NCBI Gene ID		4035
neXtProt AC		NX_Q07954
Human Synonyms		A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
Human Chr (Location)		12q13.3; chr12:57522282-57607142 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(42) : Targeted(9) Gene trapped(33)
 

Mice homozygous for a null allele exhibit lethality during late organogenesis.

 
Human Diseases Modeled Using Mouse Lrp1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	aorta morphogenesis, apoptotic cell clearance, ...
Component	clathrin-coated vesicle, coated pit, ...
Function	apolipoprotein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (143)    Tissues (48)    Images (39)
Theiler Stages: 10, 11, 13, 15, 18, 23, 25, 28

Assay Type	Results
RNA in situ	90
Northern blot	38
RT-PCR	15

cDNA source data(313)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(325) Genomic(7) cDNA(317) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031813 (Evidence)
Ensembl Gene Model	ENSMUSG00000040249 (Evidence)
Entrez Gene	16971 (Evidence)
UniGene	271854
DFCI	TC1572103, TC1624724, TC1652316
DoTS	DT.101368719, DT.110596863, DT.55167814, DT.87053456, DT.87072659
NIA Mouse Gene Index	U032341
Consensus CDS Project	CCDS24245.1
International Mouse Knockout Project Status	Lrp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031813	VEGA Gene Model | MGI Sequence Detail	82988	C57BL/6J
transcript	OTTMUST00000078868	VEGA | MGI Sequence Detail	14888	Not Applicable
polypeptide	OTTMUSP00000041991	VEGA | MGI Sequence Detail	4545	Not Applicable

All sequences(74) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(504 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006150	Cysteine-rich repeat
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000002058	low-density lipoprotein receptor-related protein 1

References

(Earliest) J:30078 Herz J, et al., Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988 Dec 20;7(13):4119-27
(Latest) J:193915 Carlo AS, et al., The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-beta peptide in the brain. J Neurosci. 2013 Jan 2;33(1):358-70
All references(129)

Other accession IDs

MGD-MRK-1007, MGD-MRK-11886, MGI:2143570