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Lrp1
Gene Detail
 Symbol
Name
ID
Lrp1
low density lipoprotein receptor-related protein 1
MGI:96828
Synonyms A2mr, b2b1554Clo, CD91
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.52 cM, cytoband B2-D1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:127538161-127621148 bp, - strand
From VEGA annotation of GRCm38

  82988 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LDL receptor-related protein
Gene Tree: Lrp1

Human
homologs
Human Homolog LRP1, low density lipoprotein receptor-related protein 1
NCBI Gene ID 4035
neXtProt AC  NX_Q07954
Human Synonyms  A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
Human Chr (Location)  12q13.3; chr12:57128499-57213359 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Chemically induced (ENU)(1) Gene trapped(33) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit lethality during late organogenesis.
 
Human Diseases Modeled Using Mouse Lrp1 (5)    Alleles Annotated to Human Diseases(2)    Phenotype Images(21)
Interactions
Lrp1 interacts with 182 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process aorta morphogenesis, apoptotic cell clearance, ...
Component clathrin-coated vesicle, coated pit, ...
Function apolipoprotein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (143)    Tissues (48)    Images (39)
Theiler Stages: 10, 11, 13, 15, 18, 23, 25, 28
Assay TypeResults
RNA in situ 90
Northern blot 38
RT-PCR 15
cDNA source data(314)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(326) Genomic(7) cDNA(318) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031813 (Evidence)
Ensembl Gene ModelENSMUSG00000040249 (Evidence)
Entrez Gene16971 (Evidence)
UniGene271854
DFCITC1572103, TC1624724, TC1652316
DoTSDT.101368719, DT.110596863, DT.55167814, DT.87053456, DT.87072659
NIA Mouse Gene IndexU032341
Consensus CDS ProjectCCDS24245.1
International Mouse Knockout Project StatusLrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031813 VEGA Gene Model | MGI Sequence Detail 82988 C57BL/6J ±  kb
transcript OTTMUST00000078868 VEGA | MGI Sequence Detail 14888 Not Applicable 
polypeptide OTTMUSP00000041991 VEGA | MGI Sequence Detail 4545 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(590 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006150 Cysteine-rich repeat
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000002058 low-density lipoprotein receptor-related protein 1
References (Earliest) J:30078 Herz J, et al., Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988 Dec 20;7(13):4119-27
(Latest) J:210621 Gu H, et al., The role of choroid plexus in IVIG-induced beta-amyloid clearance. Neuroscience. 2014 Jun 13;270:168-76
All references(144)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1007, MGD-MRK-11886, MGI:2143570, MGI:5437071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory