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Lrp1 Gene Detail
Summary
  • Symbol
    Lrp1
  • Name
    low density lipoprotein receptor-related protein 1
  • Synonyms
    A2mr, b2b1554Clo, CD91
  • Feature Type
    protein coding gene
  • IDs
    MGI:96828
    NCBI Gene: 16971
Location & Maps
more
  • Sequence Map
    Chr10:127538161-127621148 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82988 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRP1, LDL receptor related protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRP1, LDL receptor related protein 1
    Orthology source: HomoloGene
  • Synonyms
    A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
  • Links
    NCBI Gene ID: 4035
    neXtProt AC: NX_Q07954

  • Chr Location
    12q13.3; chr12:57128499-57213359 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with Lrp1 mouse models

Human Disease Mouse Models
       Alzheimer Disease; AD   OMIM: 104300 View 2 models
Diaphragmatic Hernia, Congenital   OMIM: 142340 View 1 model
Gastroschisis   OMIM: 230750 View 1 model
Omphalocele, Autosomal   OMIM: 164750 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    86 phenotypes from 9 alleles in 9 genetic backgrounds
    32 phenotypes from multigenic genotypes
    21 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    44
  • Chemically induced (ENU)
    1
  • Gene trapped
    33
  • Targeted
    10
  • Incidental Mutations
Mice homozygous for a null allele exhibit lethality during late organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031813 VEGA Gene Model | MGI Sequence Detail 82988 C57BL/6J ±  kb
transcript OTTMUST00000078868 VEGA | MGI Sequence Detail 14888 Not Applicable  
polypeptide OTTMUSP00000041991 VEGA | MGI Sequence Detail 4545 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    590 from dbSNP Build 137
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR026823 Complement Clr-like EGF domain
    IPR006150 Cysteine-rich repeat
    IPR032485 Domain of unknown function DUF5050
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR000033 LDLR class B repeat
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR011042 Six-bladed beta-propeller, TolB-like
Molecular
Reagents
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  • All nucleic 326
    Genomic 7
    cDNA 318
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1007, MGD-MRK-11886, MGI:2143570, MGI:5437071
References
more
  • Summaries
    All 152
    Developmental Gene Expression 20
    Diseases 3
    Gene Ontology 19
    Phenotypes 67
  • Earliest
    J:30078 Herz J, et al., Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988 Dec 20;7(13):4119-27
  • Latest
    J:226571 Kang LI, et al., Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Lab Invest. 2015 Oct;95(10):1117-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory