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Lrp1 Gene Detail
Summary
  • Symbol
    Lrp1
  • Name
    low density lipoprotein receptor-related protein 1
  • Synonyms
    A2mr, b2b1554Clo, CD91
  • Feature Type
    protein coding gene
  • IDs
    MGI:96828
    NCBI Gene: 16971
  • Gene Overview
    MyGene.info: LRP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127538161-127621148 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.52 cM, cytoband B2-D1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96828
protein coding gene Chr10:127538157-127621148 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017827
protein coding gene Chr10:131159698-131242448 (-)
A/J MGP_AJ_G0017802
protein coding gene Chr10:125906601-125988974 (-)
AKR/J MGP_AKRJ_G0017765
protein coding gene Chr10:129622697-129707654 (-)
BALB/cJ MGP_BALBcJ_G0017766
protein coding gene Chr10:126311060-126393569 (-)
C3H/HeJ MGP_C3HHeJ_G0017590
protein coding gene Chr10:129774259-129860842 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018221
protein coding gene Chr10:135604066-135691784 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015901
protein coding gene Chr10:119892673-119977329 (-)
CAST/EiJ MGP_CASTEiJ_G0017150
protein coding gene Chr10:130434784-130519728 (-)
CBA/J MGP_CBAJ_G0017559
protein coding gene Chr10:141068049-141163271 (-)
DBA/2J MGP_DBA2J_G0017665
protein coding gene Chr10:124982168-125066891 (-)
FVB/NJ MGP_FVBNJ_G0017660
protein coding gene Chr10:123923632-124008068 (-)
LP/J MGP_LPJ_G0017739
protein coding gene Chr10:131731109-131818469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017688
protein coding gene Chr10:143763306-143847159 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018261
protein coding gene Chr10:129688005-129779758 (-)
PWK/PhJ MGP_PWKPhJ_G0016935
protein coding gene Chr10:125187626-125271997 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016727
protein coding gene Chr10:128728877-128808395 (-)
WSB/EiJ MGP_WSBEiJ_G0017211
protein coding gene Chr10:129915183-130002844 (-)



Homology
more
  • Human Ortholog
    LRP1, LDL receptor related protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRP1, LDL receptor related protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A2MR, APOER, APR, CD91, IGFBP3R, IGFBP-3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5
  • Links
    NCBI Gene ID: 4035
    neXtProt AC: NX_Q07954
    UniProt: Q07954

  • Chr Location
    12q13.3; chr12:57128401-57213377 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    5 with Lrp1 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    112 phenotypes from 10 alleles in 10 genetic backgrounds
    32 phenotypes from multigenic genotypes
    21 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality during late organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040249 Ensembl Gene Model | MGI Sequence Detail 82988 C57BL/6J ±  kb
    transcript ENSMUST00000049149 Ensembl | MGI Sequence Detail 14888 Not Applicable  
    polypeptide ENSMUSP00000044004 Ensembl | MGI Sequence Detail 4545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR026823 Complement Clr-like EGF domain
      IPR032485 Domain of unknown function DUF5050
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR011042 Six-bladed beta-propeller, TolB-like
    Molecular
    Reagents
    less
    • All nucleic 328
      Genomic 7
      cDNA 320
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1007, MGD-MRK-11886, MGI:2143570, MGI:5437071
    References
    more
    • Summaries
      All 206
      Developmental Gene Expression 23
      Diseases 4
      Gene Ontology 24
      Phenotypes 92
    • Earliest
      J:30078 Herz J, et al., Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 1988 Dec 20;7(13):4119-27
    • Latest
      J:264537 Hamlin AN, et al., Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression. J Biol Chem. 2018 Jun 22;293(25):9674-9684

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory