112 phenotypes from 10 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lrp1b2b1554Clo/Lrp1b2b1554Clo C57BL/6J-Lrp1b2b1554Clo	abnormal body wall morphology	J:175213
	abnormal heart ventricle outflow tract morphology	J:175213
	atrioventricular septal defect	J:175213
	diaphragmatic hernia	J:175213
	herniated abdominal wall	J:175213
	omphalocele	J:175213
Lrp1tm1.1(KOMP)Wtsi/Lrp1+ C57BL/6N-Lrp1tm1.1(KOMP)Wtsi/J	increased circulating alkaline phosphatase level	J:211773
	increased heart weight	J:211773
Lrp1tm1.1(KOMP)Wtsi/Lrp1tm1.1(KOMP)Wtsi C57BL/6N-Lrp1tm1.1(KOMP)Wtsi/J	abnormal craniofacial morphology	J:211773
	abnormal embryo size	J:211773
	abnormal forebrain morphology	J:211773
	abnormal limb bud morphology	J:211773
	hemorrhage	J:211773
	microphthalmia	J:211773
	preweaning lethality, complete penetrance	J:211773
Lrp1tm1Ajmr/Lrp1tm1Ajmr involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:144146
Lrp1tm1Her/Lrp1tm1Her involves: 129S7/SvEvBrd	embryonic growth retardation	J:30077
	embryonic lethality during organogenesis, complete penetrance	J:30077
	internal hemorrhage	J:30077
Lrp1tm2Ajmr/Lrp1tm2Ajmr involves: 129P2/OlaHsd * C57BL/6	abnormal liver morphology	J:144146
Lrp1tm2Her/Lrp1tm2Her involves: 129S7/SvEvBrd	abnormal liver physiology	J:76281
	normal homeostasis/metabolism phenotype	J:67929
Lrp1tm2Her/Lrp1tm2Her Tg(Camk2a-cre)T29-1Stl/0 involves: 129S7/SvEvBrd * BALB/c * C57BL	abnormal associative learning	J:167724
	abnormal lipid level	J:167724
	abnormal motor capabilities/coordination/movement	J:167724
	abnormal nervous system physiology	J:167724
	abnormal synapse morphology	J:167724
	brain inflammation	J:167724
	decreased brain cholesterol level	J:167724
	decreased dendritic spine density	J:167724
	decreased triglyceride level	J:167724
	hyperactivity	J:167724
	impaired contextual conditioning behavior	J:167724
	impaired coordination	J:167724
	impaired cued conditioning behavior	J:167724
	limb grasping	J:167724
	neurodegeneration	J:167724
	reduced long-term potentiation	J:167724
Lrp1tm2Her/Lrp1tm2Her Tg(Fabp4-cre)1Rev/0 involves: 129S7/SvEvBrd * C57BL/6	abnormal adipose tissue amount	J:127398
	abnormal adipose tissue physiology	J:127398
	abnormal body temperature homeostasis	J:127398
	abnormal brown fat cell morphology	J:127398
	abnormal circulating lipid level	J:127398
	abnormal fat pad morphology	J:127398
	abnormal glucose homeostasis	J:127398
	abnormal lipid homeostasis	J:127398
	decreased body surface temperature	J:127398
	decreased body weight	J:127398
	decreased brown adipose tissue amount	J:127398
	decreased brown fat cell size	J:127398
	decreased brown fat lipid droplet number	J:127398
	decreased circulating free fatty acids level	J:127398
	decreased circulating glucose level	J:127398
	decreased circulating insulin level	J:127398
	decreased circulating leptin level	J:127398
	decreased epididymal fat pad weight	J:127398
	decreased interscapular fat pad weight	J:127398
	decreased liver triglyceride level	J:127398
	decreased susceptibility to diet-induced obesity	J:127398
	decreased total body fat amount	J:127398
	decreased white fat cell size	J:127398
	normal homeostasis/metabolism phenotype	J:127398
	impaired adaptive thermogenesis	J:127398
	improved glucose tolerance	J:127398
	increased energy expenditure	J:127398
	increased food intake	J:127398
	increased muscle cell glucose uptake	J:127398
	increased oxygen consumption	J:127398
	increased susceptibility to weight loss	J:127398
	trunk curl	J:127398
Lrp1tm2Her/Lrp1tm2Her Tg(Mx1-cre)29-4Her/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal circulating protein level	J:117317
	increased circulating factor VIII level	J:117317
	increased circulating von Willebrand factor level	J:117317
Lrp1tm2Her/Lrp1tm2Her Tg(Mx1-cre)29-4Her/0 involves: 129S7/SvEvBrd * C57BL/6J * SJL	abnormal blood homeostasis	J:83443
	abnormal liver physiology	J:83443
	increased circulating factor VIII level	J:83443
	increased circulating von Willebrand factor level	J:83443
Lrp1tm2Her/Lrp1tm2Her Tg(Syn1-cre)671Jxm/0 involves: 129S7/SvEvBrd * C57BL/6 * CBA	abnormal gait	J:93329
	abnormal limb posture	J:93329
	abnormal posture	J:93329
	decreased circulating insulin level	J:93329
	decreased total body fat amount	J:93329
	hyperactivity	J:93329
	hypoglycemia	J:93329
	impaired limb coordination	J:93329
	increased food intake	J:93329
	kyphosis	J:93329
	limb grasping	J:93329
	normal nervous system phenotype	J:93329
	postnatal growth retardation	J:93329
	premature death	J:93329
	reduced fertility	J:93329
	tremors	J:93329
	weakness	J:93329
Lrp1tm2Her/Lrp1tm2Her Tg(Tagln-cre)1Her/0 B6.Cg-Lrp1tm2Her Tg(Tagln-cre)1Her	abnormal aorta elastic tissue morphology	J:167799
	abnormal aorta smooth muscle morphology	J:167799
	abnormal aorta tunica media morphology	J:167799
	abnormal vascular smooth muscle physiology	J:167799
	abnormal vascular wound healing	J:167799
	decreased vasoconstriction	J:167799
Lrp1tm2Her/Lrp1tm2Her Tg(Tagln-cre)1Her/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal ascending aorta morphology	J:209752
	abnormal coronary artery morphology	J:209752
	abnormal heart echocardiography feature	J:209752
	abnormal myocardial fiber morphology	J:209752
	aortic valve regurgitation	J:209752
	cardiac interstitial fibrosis	J:209752
	decreased cardiac muscle contractility	J:209752
	decreased systemic arterial diastolic blood pressure	J:209752
	dilated aorta bulb	J:209752
	dilated ascending aorta	J:209752
	dilated cardiomyopathy	J:209752
	dilated heart left ventricle	J:209752
	enlarged heart	J:209752
	increased heart left ventricle size	J:209752
	increased heart weight	J:209752
	increased pulse pressure	J:209752
	perivascular fibrosis	J:209752
Lrp1tm3Ajmr/Lrp1tm3Ajmr involves: 129P2/OlaHsd * C57BL/6	abnormal liver perisinusoidal space morphology	J:144146
	decreased hepatocyte number	J:144146
	lethality throughout fetal growth and development, incomplete penetrance	J:144146
	liver degeneration	J:144146
	perinatal lethality, complete penetrance	J:144146
Lrp1tm4Ajmr/Lrp1tm4Ajmr involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:144146
Lrp1tm5Ajmr/Lrp1tm5Ajmr involves: 129P2/OlaHsd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:186908
Lrp1tm6Ajmr/Lrp1tm6Ajmr involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:186908