Phenotypes Associated with This Genotype

Genotype
MGI:4943741

• Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain cholesterol level ( J:167724 )

• in the cortex of the brain at 12 months of age

decreased dendritic spine density ( J:167724 )

• decrease in spine densities of apical oblique and basal shaft dendrites of pyramidal neurons in the cortex and in the CA1 region of the hippocampus at 18 months but not at 12 months of age

abnormal synapse morphology ( J:167724 )

• expression analysis indicates an age dependent decrease in synaptic density

neurodegeneration ( J:167724 )

• significant increase in apoptotic cells in the cortex and hippocampus at 24 months but not at 18 months of age

abnormal nervous system physiology ( J:167724 )

• significantly lower levels of sulfatide, galactosylceramide, cholesterol and triglyceride in the cortex of the brain at 12 months of age

• amyloid-beta levels are decreased in the hippocampus at 18 months of age, indicating that the neurodegeneration likely occurs by an amyloid-beta independent mechanism

brain inflammation ( J:167724 )

• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age

reduced long-term potentiation ( J:167724 )

• severely reduced in hippocampal slices at 18 months of age

behavior/neurological

abnormal associative learning ( J:167724 )

impaired contextual conditioning behavior ( J:167724 )

• exhibit significantly less freezing time than controls at 18 months of age

impaired cued conditioning behavior ( J:167724 )

• exhibit significantly less freezing time than controls at 18 months of age

abnormal motor capabilities/coordination/movement ( J:167724 )

limb grasping ( J:167724 )

• develops by 13 months of age

impaired coordination ( J:167724 )

• at 18 months of age

hyperactivity ( J:167724 )

• in an open field test at 18 months of age

homeostasis/metabolism

abnormal lipid level ( J:167724 )

• significantly lower levels of sulfatide and galactosylceramide in the cortex of the brain at 12 months of age

decreased brain cholesterol level ( J:167724 )

• in the cortex of the brain at 12 months of age

decreased triglyceride level ( J:167724 )

• in the cortex of the brain at 12 months of age

immune system

brain inflammation ( J:167724 )

• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:167724