Automated description from the Alliance of Genome Resources (Release 9.0.0)
Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cholesterol transport; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and transforming growth factor beta receptor signaling pathway. Located in plasma membrane. Is active in several cellular components, including external side of plasma membrane; focal adhesion; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).
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