| GO term: | apoptotic cell clearance |
| Synonym: | apoptotic cell removal |
| Synonym: | efferocytosis |
| Synonym: | programmed cell clearance |
| GO id: | GO:0043277 |
| Definition: | The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. |
| Comments | Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. |
| Number of paths to term: | 5 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processestablishment of localizationtransportsingle-organism transportphagocytosisapoptotic cell clearance [GO:0043277] (20 genes, 29 annotations)engulfment of apoptotic cell +negative regulation of apoptotic cell clearancephagosome maturation involved in apoptotic cell clearance +positive regulation of apoptotic cell clearancerecognition of apoptotic cellregulation of apoptotic cell clearance +Fc-gamma receptor signaling pathway involved in phagocytosisimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +negative regulation of phagocytosis +opsonizationphagocytosis, engulfment +phagocytosis, recognition +phagolysosome assembly +positive regulation of phagocytosis +regulation of phagocytosis +biological_processestablishment of localizationtransportvesicle-mediated transportendocytosisphagocytosisapoptotic cell clearance [GO:0043277] (20 genes, 29 annotations)engulfment of apoptotic cell +negative regulation of apoptotic cell clearancephagosome maturation involved in apoptotic cell clearance +positive regulation of apoptotic cell clearancerecognition of apoptotic cellregulation of apoptotic cell clearance +Fc-gamma receptor signaling pathway involved in phagocytosisimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +negative regulation of phagocytosis +opsonizationphagocytosis, engulfment +phagocytosis, recognition +phagolysosome assembly +positive regulation of phagocytosis +regulation of phagocytosis +biological_processlocalizationestablishment of localizationtransportsingle-organism transportphagocytosisapoptotic cell clearance [GO:0043277] (20 genes, 29 annotations)engulfment of apoptotic cell +negative regulation of apoptotic cell clearancephagosome maturation involved in apoptotic cell clearance +positive regulation of apoptotic cell clearancerecognition of apoptotic cellregulation of apoptotic cell clearance +Fc-gamma receptor signaling pathway involved in phagocytosisimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +negative regulation of phagocytosis +opsonizationphagocytosis, engulfment +phagocytosis, recognition +phagolysosome assembly +positive regulation of phagocytosis +regulation of phagocytosis +biological_processlocalizationestablishment of localizationtransportvesicle-mediated transportendocytosisphagocytosisapoptotic cell clearance [GO:0043277] (20 genes, 29 annotations)engulfment of apoptotic cell +negative regulation of apoptotic cell clearancephagosome maturation involved in apoptotic cell clearance +positive regulation of apoptotic cell clearancerecognition of apoptotic cellregulation of apoptotic cell clearance +Fc-gamma receptor signaling pathway involved in phagocytosisimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +negative regulation of phagocytosis +opsonizationphagocytosis, engulfment +phagocytosis, recognition +phagolysosome assembly +positive regulation of phagocytosis +regulation of phagocytosis +biological_processsingle-organism processsingle-organism transportphagocytosisapoptotic cell clearance [GO:0043277] (20 genes, 29 annotations)engulfment of apoptotic cell +negative regulation of apoptotic cell clearancephagosome maturation involved in apoptotic cell clearance +positive regulation of apoptotic cell clearancerecognition of apoptotic cellregulation of apoptotic cell clearance +Fc-gamma receptor signaling pathway involved in phagocytosisimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +negative regulation of phagocytosis +opsonizationphagocytosis, engulfment +phagocytosis, recognition +phagolysosome assembly +positive regulation of phagocytosis +regulation of phagocytosis +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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