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Gene Ontology Browser
Term Detail
GO term:apoptotic cell clearance
Synonym: apoptotic cell removal
Synonym: efferocytosis
Synonym: programmed cell clearance
GO id:GO:0043277
Definition:The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
CommentsNote that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-asingle-organism transport
                                                is-aphagocytosis
                                                        is-aapoptotic cell clearance [GO:0043277] (27 genes, 38 annotations)
                                                                part-ofengulfment of apoptotic cell +
                                                                negatively-regulatesnegative regulation of apoptotic cell clearance +
                                                                part-ofphagosome maturation involved in apoptotic cell clearance +
                                                                positively-regulatespositive regulation of apoptotic cell clearance +
                                                                part-ofrecognition of apoptotic cell
                                                                regulatesregulation of apoptotic cell clearance +
                                                        part-ofFc-gamma receptor signaling pathway involved in phagocytosis
                                                        part-ofimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +
                                                        negatively-regulatesnegative regulation of phagocytosis +
                                                        part-ofopsonization +
                                                        part-ofphagocytosis, engulfment +
                                                        part-ofphagocytosis, recognition +
                                                        part-ofphagolysosome assembly +
                                                        positively-regulatespositive regulation of phagocytosis +
                                                        regulatesregulation of phagocytosis +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-avesicle-mediated transport
                                                is-aendocytosis
                                                        is-aphagocytosis
                                                                is-aapoptotic cell clearance [GO:0043277] (27 genes, 38 annotations)
                                                                        part-ofengulfment of apoptotic cell +
                                                                        negatively-regulatesnegative regulation of apoptotic cell clearance +
                                                                        part-ofphagosome maturation involved in apoptotic cell clearance +
                                                                        positively-regulatespositive regulation of apoptotic cell clearance +
                                                                        part-ofrecognition of apoptotic cell
                                                                        regulatesregulation of apoptotic cell clearance +
                                                                part-ofFc-gamma receptor signaling pathway involved in phagocytosis
                                                                part-ofimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +
                                                                negatively-regulatesnegative regulation of phagocytosis +
                                                                part-ofopsonization +
                                                                part-ofphagocytosis, engulfment +
                                                                part-ofphagocytosis, recognition +
                                                                part-ofphagolysosome assembly +
                                                                positively-regulatespositive regulation of phagocytosis +
                                                                regulatesregulation of phagocytosis +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-aphagocytosis
                                                is-aapoptotic cell clearance [GO:0043277] (27 genes, 38 annotations)
                                                        part-ofengulfment of apoptotic cell +
                                                        negatively-regulatesnegative regulation of apoptotic cell clearance +
                                                        part-ofphagosome maturation involved in apoptotic cell clearance +
                                                        positively-regulatespositive regulation of apoptotic cell clearance +
                                                        part-ofrecognition of apoptotic cell
                                                        regulatesregulation of apoptotic cell clearance +
                                                part-ofFc-gamma receptor signaling pathway involved in phagocytosis
                                                part-ofimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +
                                                negatively-regulatesnegative regulation of phagocytosis +
                                                part-ofopsonization +
                                                part-ofphagocytosis, engulfment +
                                                part-ofphagocytosis, recognition +
                                                part-ofphagolysosome assembly +
                                                positively-regulatespositive regulation of phagocytosis +
                                                regulatesregulation of phagocytosis +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-aphagocytosis
                                                is-aapoptotic cell clearance [GO:0043277] (27 genes, 38 annotations)
                                                        part-ofengulfment of apoptotic cell +
                                                        negatively-regulatesnegative regulation of apoptotic cell clearance +
                                                        part-ofphagosome maturation involved in apoptotic cell clearance +
                                                        positively-regulatespositive regulation of apoptotic cell clearance +
                                                        part-ofrecognition of apoptotic cell
                                                        regulatesregulation of apoptotic cell clearance +
                                                part-ofFc-gamma receptor signaling pathway involved in phagocytosis
                                                part-ofimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +
                                                negatively-regulatesnegative regulation of phagocytosis +
                                                part-ofopsonization +
                                                part-ofphagocytosis, engulfment +
                                                part-ofphagocytosis, recognition +
                                                part-ofphagolysosome assembly +
                                                positively-regulatespositive regulation of phagocytosis +
                                                regulatesregulation of phagocytosis +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism transport
                                is-aphagocytosis
                                        is-aapoptotic cell clearance [GO:0043277] (27 genes, 38 annotations)
                                                part-ofengulfment of apoptotic cell +
                                                negatively-regulatesnegative regulation of apoptotic cell clearance +
                                                part-ofphagosome maturation involved in apoptotic cell clearance +
                                                positively-regulatespositive regulation of apoptotic cell clearance +
                                                part-ofrecognition of apoptotic cell
                                                regulatesregulation of apoptotic cell clearance +
                                        part-ofFc-gamma receptor signaling pathway involved in phagocytosis
                                        part-ofimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis +
                                        negatively-regulatesnegative regulation of phagocytosis +
                                        part-ofopsonization +
                                        part-ofphagocytosis, engulfment +
                                        part-ofphagocytosis, recognition +
                                        part-ofphagolysosome assembly +
                                        positively-regulatespositive regulation of phagocytosis +
                                        regulatesregulation of phagocytosis +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory