Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lpar1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LPAR1
- Mouse genes Lpar1
- Rat genes Lpar1
- Zfish genes lpar1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lpar1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Lpar1	IMP		Rat	PMID:16504475\|RGD:1626471
Molecular Function	GO:0035727	lysophosphatidic acid binding	LPAR1	IDA		Human	PMID:9070858
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	LPAR1	IDA		Human	PMID:19306925
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	LPAR1	IMP		Human	PMID:9070858
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	Lpar1	IDA		Mouse	MGI:MGI:84257\|PMID:8922387
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	Lpar1	IDA		Mouse	MGI:MGI:5645214\|PMID:9600933
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	lpar1	IDA		Zfish	PMID:21971049
Molecular Function	GO:0030165	PDZ domain binding	Lpar1	IPI	UniProtKB:Q9NZN5	Mouse	PMID:15755723
Molecular Function	GO:0030165	PDZ domain binding	Lpar1	IPI	UniProtKB:O15085	Mouse	PMID:15755723
Molecular Function	GO:0005543	phospholipid binding	Lpar1	IDA		Rat	PMID:16242672\|RGD:1626474
Molecular Function	GO:0005543	phospholipid binding	Lpar1	IMP		Rat	PMID:16504475\|RGD:1626471
Molecular Function	GO:0005515	protein binding	LPAR1	IPI	UniProtKB:P11233	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	LPAR1	IPI	UniProtKB:P25098	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	Lpar1	IPI	UniProtKB:Q9NZN5	Mouse	MGI:MGI:3584233\|PMID:15755723
Cellular Component	GO:0009986	cell surface	LPAR1	IDA		Human	PMID:19306925
Cellular Component	GO:0005737	cytoplasm	Lpar1	IDA		Rat	PMID:18978343\|RGD:2317687
Cellular Component	GO:0043198	dendritic shaft	Lpar1	IDA		Rat	PMID:16638019\|RGD:2317707
Cellular Component	GO:0043197	dendritic spine	Lpar1	IDA		Rat	PMID:16638019\|RGD:2317707
Cellular Component	GO:0030139	endocytic vesicle	LPAR1	IDA		Human	PMID:19306925
Cellular Component	GO:0005768	endosome	LPAR1	IDA		Human	PMID:19306925
Cellular Component	GO:0098982	GABA-ergic synapse	Lpar1	EXP		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0098982	GABA-ergic synapse	Lpar1	IDA		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0098982	GABA-ergic synapse	Lpar1	IMP		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0098978	glutamatergic synapse	Lpar1	EXP		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0098978	glutamatergic synapse	Lpar1	IDA		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0098978	glutamatergic synapse	Lpar1	IMP		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0043005	neuron projection	Lpar1	IDA		Rat	PMID:11948806\|RGD:10054294
Cellular Component	GO:0043025	neuronal cell body	Lpar1	IDA		Rat	PMID:11948806\|RGD:10054294
Cellular Component	GO:0005886	plasma membrane	LPAR1	IDA		Human	PMID:19306925
Cellular Component	GO:0005886	plasma membrane	Lpar1	IDA		Mouse	MGI:MGI:5645214\|PMID:9600933
Cellular Component	GO:0005886	plasma membrane	Lpar1	IDA		Mouse	MGI:MGI:84257\|PMID:8922387
Cellular Component	GO:0005886	plasma membrane	Lpar1	IDA		Rat	PMID:11948806\|RGD:10054294
Cellular Component	GO:0005886	plasma membrane	Lpar1	IDA		Rat	PMID:18978343\|RGD:2317687
Cellular Component	GO:0045211	postsynaptic membrane	Lpar1	IDA		Rat	PMID:25996636\|RGD:155230734
Cellular Component	GO:0042734	presynaptic membrane	Lpar1	IDA		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0007202	activation of phospholipase C activity	LPAR1	IDA		Human	PMID:19306925
Biological Process	GO:0007202	activation of phospholipase C activity	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Biological Process	GO:0001525	angiogenesis	lpar1	IGI	ZFIN:ZDB-MRPHLNO-090126-5,ZFIN:ZDB-MRPHLNO-120202-2	Zfish	PMID:21971049
Biological Process	GO:0001525	angiogenesis	lpar1	IGI	ZFIN:ZDB-MRPHLNO-090126-5,ZFIN:ZDB-MRPHLNO-120202-3	Zfish	PMID:21971049
Biological Process	GO:0032060	bleb assembly	Lpar1	IGI	MGI:MGI:1929469	Mouse	PMID:17135244
Biological Process	GO:0007420	brain development	Lpar1	IEP		Rat	PMID:10384882\|RGD:2317715
Biological Process	GO:0051216	cartilage development	lpar1	IMP	ZFIN:ZDB-GENO-170321-1	Zfish	PMID:27005960
Biological Process	GO:0051216	cartilage development	lpar1	IMP	ZFIN:ZDB-MRPHLNO-090126-5	Zfish	PMID:27005960
Biological Process	GO:0060326	cell chemotaxis	LPAR1	IMP		Human	PMID:19733258
Biological Process	GO:1904566	cellular response to 1-oleoyl-sn-glycerol 3-phosphate	Lpar1	IDA		Rat	PMID:12139919\|RGD:727395
Biological Process	GO:0071453	cellular response to oxygen levels	Lpar1	IEP		Rat	PMID:18978343\|RGD:2317687
Biological Process	GO:0021549	cerebellum development	Lpar1	IEP		Rat	PMID:9753172\|RGD:2317716
Biological Process	GO:0022038	corpus callosum development	Lpar1	IEP		Rat	PMID:9753172\|RGD:2317716
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Lpar1	IDA		Mouse	MGI:MGI:5645214\|PMID:9600933
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Lpar1	IDA		Mouse	MGI:MGI:84257\|PMID:8922387
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Lpar1	IDA		Mouse	PMID:15755723
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Lpar1	IMP		Rat	PMID:16504475\|RGD:1626471
Biological Process	GO:0060217	hemangioblast cell differentiation	lpar1	IMP	ZFIN:ZDB-MRPHLNO-150827-1	Zfish	PMID:24829209
Biological Process	GO:0001946	lymphangiogenesis	lpar1	IMP	ZFIN:ZDB-MRPHLNO-090126-5	Zfish	PMID:18606866
Biological Process	GO:0001946	lymphangiogenesis	lpar1	IMP	ZFIN:ZDB-MRPHLNO-090126-6	Zfish	PMID:18606866
Biological Process	GO:0042552	myelination	Lpar1	IEP		Rat	PMID:10384882\|RGD:2317715
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Lpar1	IDA		Rat	PMID:12139919\|RGD:727395
Biological Process	GO:0010977	negative regulation of neuron projection development	Lpar1	IMP		Mouse	MGI:MGI:5645214\|PMID:9600933
Biological Process	GO:0010977	negative regulation of neuron projection development	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Biological Process	GO:0010977	negative regulation of neuron projection development	Lpar1	IMP		Rat	PMID:18978343\|RGD:2317687
Biological Process	GO:0022008	neurogenesis	Lpar1	IEP		Rat	PMID:9753172\|RGD:2317716
Biological Process	GO:0014003	oligodendrocyte development	Lpar1	IEP		Rat	PMID:11948806\|RGD:10054294
Biological Process	GO:0021554	optic nerve development	Lpar1	IEP		Rat	PMID:12139919\|RGD:727395
Biological Process	GO:0043065	positive regulation of apoptotic process	Lpar1	IMP		Rat	PMID:16890224\|RGD:2317699
Biological Process	GO:0043065	positive regulation of apoptotic process	Lpar1	IMP		Rat	PMID:18978343\|RGD:2317687
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	LPAR1	IMP		Human	PMID:19733258
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Lpar1	IDA		Rat	PMID:16242672\|RGD:1626474
Biological Process	GO:0060999	positive regulation of dendritic spine development	Lpar1	IDA		Rat	PMID:16638019\|RGD:2317707
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	LPAR1	IEP		Human	PMID:12761501
Biological Process	GO:0043410	positive regulation of MAPK cascade	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Biological Process	GO:0043410	positive regulation of MAPK cascade	Lpar1	IDA		Mouse	PMID:15755723
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	Lpar1	IMP		Mouse	MGI:MGI:5645214\|PMID:9600933
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	Lpar1	IDA		Mouse	PMID:15755723
Biological Process	GO:0071673	positive regulation of smooth muscle cell chemotaxis	Lpar1	IMP		Rat	PMID:19742132\|RGD:2317679
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Lpar1	IDA		Mouse	MGI:MGI:5645214\|PMID:9600933
Biological Process	GO:0060215	primitive hemopoiesis	lpar1	IMP	ZFIN:ZDB-MRPHLNO-150827-1	Zfish	PMID:24829209
Biological Process	GO:0008360	regulation of cell shape	Lpar1	IDA		Mouse	MGI:MGI:84257\|PMID:8922387
Biological Process	GO:0008360	regulation of cell shape	Lpar1	IDA		Mouse	MGI:MGI:5645211\|PMID:11040035
Biological Process	GO:0008360	regulation of cell shape	Lpar1	IMP		Mouse	MGI:MGI:5645214\|PMID:9600933
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Lpar1	EXP		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Lpar1	IDA		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Lpar1	IEP		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Lpar1	IMP		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Lpar1	EXP		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Lpar1	IDA		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Lpar1	IEP		Rat	PMID:25996636\|RGD:155230734
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Lpar1	IMP		Rat	PMID:25996636\|RGD:155230734

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.