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Lpar1 Gene Detail
Summary
  • Symbol
    Lpar1
  • Name
    lysophosphatidic acid receptor 1
  • Synonyms
    Edg2, Gpcr26, Kdt2, LPA1, vzg-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108429
    NCBI Gene: 14745
  • Gene Overview
    MyGene.info: LPAR1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:58435255-58553898 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 32.20 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    792 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108429
protein coding gene Chr4:58435252-58554027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028325
protein coding gene Chr4:57267860-57391925 (-)
A/J MGP_AJ_G0028286
protein coding gene Chr4:55080794-55202336 (-)
AKR/J MGP_AKRJ_G0028235
protein coding gene Chr4:56607519-56732740 (-)
BALB/cJ MGP_BALBcJ_G0028305
protein coding gene Chr4:55240006-55366361 (-)
C3H/HeJ MGP_C3HHeJ_G0028026
protein coding gene Chr4:57100898-57229477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028746
protein coding gene Chr4:59282231-59416707 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026052
protein coding gene Chr4:51849548-51963617 (-)
CAST/EiJ MGP_CASTEiJ_G0027464
protein coding gene Chr4:56859981-56985363 (-)
CBA/J MGP_CBAJ_G0027991
protein coding gene Chr4:61301440-61440028 (-)
DBA/2J MGP_DBA2J_G0028141
protein coding gene Chr4:54978196-55097833 (-)
FVB/NJ MGP_FVBNJ_G0028108
protein coding gene Chr4:54210729-54328271 (-)
LP/J MGP_LPJ_G0028240
protein coding gene Chr4:57368969-57497417 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028132
protein coding gene Chr4:64430845-64564679 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028782
protein coding gene Chr4:56809914-56935975 (-)
PWK/PhJ MGP_PWKPhJ_G0027189
protein coding gene Chr4:54992013-55118342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027017
protein coding gene Chr4:56099345-56231815 (-)
WSB/EiJ MGP_WSBEiJ_G0027542
protein coding gene Chr4:56765370-56896902 (-)



Homology
more
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1
  • Links
    NCBI Gene ID: 1902
    neXtProt AC: NX_Q92633
    UniProt: Q92633

  • Chr Location
    9q31.3; chr9:110873252-111039259 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations cause partial peri- and postnatal lethality, growth defects, craniofacial anomalies, and wide set eyes. Additional phenotypes include altered brain 5-HT and amino acids, reduced prepulse inhibition, impaired suckling, and increased apoptosis in sciatic nerve Schwann cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038668 Ensembl Gene Model | MGI Sequence Detail 118644 C57BL/6J ±  kb
    transcript ENSMUST00000055018 Ensembl | MGI Sequence Detail 3512 Not Applicable  
    polypeptide ENSMUSP00000052581 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 30
      cDNA 69
      Primer pair 8
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
    • Latest
      J:263937 Magkrioti C, et al., The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis. Cancer Res. 2018 Jul 1;78(13):3634-3644

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory