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Lpar1
Gene Detail
Symbol

Name
ID
Lpar1
lysophosphatidic acid receptor 1
MGI:108429
Synonyms
Edg2, Gpcr26, Kdt2, LPA1, vzg-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
32.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:58435255-58553898 bp, - strand
From VEGA annotation of GRCm38

  118644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1072  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LPAR1
Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar1

Human
homologs
LPAR1, lysophosphatidic acid receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1902
neXtProt AC: NX_Q92633

Human Synonyms: edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1

Human Chr (Location): 9q31.3; chr9:110873261-111039243 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(58) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(3)
Interactions
Lpar1 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPK activity, bleb assembly, ...
Component cell surface, cytoplasm, ...
Function G-protein alpha-subunit binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (236)    Tissues (137)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
Northern blot 24
RT-PCR 47
cDNA source data(68)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lpar1 ; ZFIN lpar1    NEW 
Molecular
reagents
All nucleic(111) Genomic(30) cDNA(68) Primer pair(8) Other(5)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000007519 (Evidence)
Ensembl Gene Model ENSMUSG00000038668 (Evidence)
Entrez Gene 14745 (Evidence)
UniGene 4772
DFCI TC1613080, TC1592407, TC1576343, TC1707497
DoTS DT.485777, DT.110839572, DT.101393696, DT.91447595, DT.94367980
NIA Mouse Gene Index U025113
Consensus CDS Project CCDS18212.1, CCDS71391.1
International Mouse Phenotyping Consortium Status Lpar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007519 VEGA Gene Model | MGI Sequence Detail 118644 C57BL/6J ±  kb
transcript OTTMUST00000017338 VEGA | MGI Sequence Detail 3512 Not Applicable 
polypeptide OTTMUSP00000008010 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(22) UniProt(5)
Polymorphisms
PCR(4) : SNPs within 2kb(797 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004065 Lysophosphatidic acid receptor
InterPro IPR002277 Lysophosphatidic acid receptor EDG-2
Protein Ontology PR:000001684 lysophosphatidic acid receptor 1
References
(Earliest) J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
(Latest) J:213690 Jang Y, et al., TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch. 2014 Oct;466(10):1987-98
All references(89)
Other
accession IDs
MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory