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Lpar1 Gene Detail
Summary
  • Symbol
    Lpar1
  • Name
    lysophosphatidic acid receptor 1
  • Synonyms
    Edg2, Gpcr26, Kdt2, LPA1, vzg-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108429
    NCBI Gene: 14745
  • Gene Overview
    MyGene.info: LPAR1
Location & Maps
more
  • Sequence Map
    Chr4:58435255-58553898 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118644 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 32.20 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1
  • Links
    NCBI Gene ID: 1902
    neXtProt AC: NX_Q92633

  • Chr Location
    9q31.3; chr9:110873261-111039243 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Gene trapped
    58
  • Targeted
    5
  • Incidental Mutations
Nullizygous mutations cause partial peri- and postnatal lethality, growth defects, craniofacial anomalies, and wide set eyes. Additional phenotypes include altered brain 5-HT and amino acids, reduced prepulse inhibition, impaired suckling, and increased apoptosis in sciatic nerve Schwann cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007519 VEGA Gene Model | MGI Sequence Detail 118644 C57BL/6J ±  kb
transcript OTTMUST00000017341 VEGA | MGI Sequence Detail 3437 Not Applicable  
polypeptide OTTMUSP00000008013 VEGA | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    792 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001684 lysophosphatidic acid receptor 1
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR004065 Lysophosphatidic acid receptor
    IPR002277 Lysophosphatidic acid receptor EDG-2
Molecular
Reagents
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  • All nucleic 111
    Genomic 30
    cDNA 68
    Primer pair 8
    Other 5

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243
References
more
  • Summaries
    All 90
    Developmental Gene Expression 20
    Gene Ontology 9
    Phenotypes 35
  • Earliest
    J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
  • Latest
    J:213690 Jang Y, et al., TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch. 2014 Oct;466(10):1987-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory