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Lpar1
Gene Detail
Symbol

Name
ID
Lpar1
lysophosphatidic acid receptor 1
MGI:108429
Synonyms
Edg2, Gpcr26, Kdt2, LPA1, vzg-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
32.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:58435255-58553898 bp, - strand
From VEGA annotation of GRCm38

  118644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1072  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar1

Human
homologs
Human Homolog LPAR1, lysophosphatidic acid receptor 1
NCBI Gene ID 1902
neXtProt AC  NX_Q92633
Human Synonyms  edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1
Human Chr (Location)  9q31.3; chr9:110873262-111039243 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(58) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous animals for a targeted null alleles exhibit some perinatal mortality. Survivors show reduced size and craniofacial dysmorphism.
 
Phenotype Images(3)
Interactions
Lpar1 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPK activity, bleb assembly, ...
Component cell surface, cytoplasm, ...
Function G-protein alpha-subunit binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (236)    Tissues (137)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
Northern blot 24
RT-PCR 47
cDNA source data(68)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) Genomic(30) cDNA(68) Primer pair(8) Other(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000007519 (Evidence)
Ensembl Gene ModelENSMUSG00000038668 (Evidence)
Entrez Gene14745 (Evidence)
UniGene4772
DFCITC1613080, TC1592407, TC1576343, TC1707497
DoTSDT.101393696, DT.91447595, DT.485777, DT.110839572, DT.94367980
NIA Mouse Gene IndexU025113
Consensus CDS ProjectCCDS18212.1, CCDS71391.1
International Mouse Knockout Project StatusLpar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007519 VEGA Gene Model | MGI Sequence Detail 118644 C57BL/6J ±  kb
transcript OTTMUST00000017338 VEGA | MGI Sequence Detail 3512 Not Applicable 
polypeptide OTTMUSP00000008010 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(9)
Polymorphisms
PCR(4) : SNPs within 2kb(797 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004065 Lysophosphatidic acid receptor
InterPro IPR002277 Lysophosphatidic acid receptor EDG-2
Protein Ontology PR:000001684 lysophosphatidic acid receptor 1
References
(Earliest) J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
(Latest) J:210684 David M, et al., Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem. 2014 Mar 7;289(10):6551-64
All references(89)
Other
accession IDs
MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory