Lpar1
Gene Detail

Symbol Name ID

Lpar1 lysophosphatidic acid receptor 1 MGI:108429

Synonyms

Edg2, Gpcr26, Kdt2, LPA1, vzg-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

32.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:58435255-58553898 bp, - strand From VEGA annotation of GRCm38   118644 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1072  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar1

Human homologs

Human Homolog		LPAR1, lysophosphatidic acid receptor 1
NCBI Gene ID		1902
neXtProt AC		NX_Q92633
Human Synonyms		edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1
Human Chr (Location)		9q31.3; chr9:113636054-113800365 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(62) : Targeted(4) Gene trapped(58)
 

Homozygous animals for a targeted null alleles exhibit some perinatal mortality. Survivors show reduced size and craniofacial dysmorphism.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	activation of MAPK activity, bleb assembly, ...
Component	cell surface, cytoplasm, ...
Function	G-protein alpha-subunit binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (173)    Tissues (96)    Images (20)
Theiler Stages: 11, 13, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	102
Northern blot	24
RT-PCR	47

cDNA source data(66)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(108) Genomic(30) cDNA(66) Primer pair(7) Other(5)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000007519 (Evidence)
Ensembl Gene Model	ENSMUSG00000038668 (Evidence)
Entrez Gene	14745 (Evidence)
UniGene	4772
DFCI	TC1576343, TC1592407, TC1613080
DoTS	DT.101393696, DT.110839572, DT.485777, DT.91447595, DT.94367980
NIA Mouse Gene Index	U025113
Consensus CDS Project	CCDS18212.1
International Mouse Knockout Project Status	Lpar1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007519	VEGA Gene Model | MGI Sequence Detail	118644	C57BL/6J
transcript	OTTMUST00000017338	VEGA | MGI Sequence Detail	3512	Not Applicable
polypeptide	OTTMUSP00000008010	VEGA | MGI Sequence Detail	364	Not Applicable

All sequences(69) RefSeq(4) UniProt(5)

Polymorphisms

PCR(4) : SNPs(646 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR004065	Lysophosphatidic acid receptor
InterPro	IPR002277	Lysophosphatidic acid receptor EDG-2
Protein Ontology	PR:000001684	lysophosphatidic acid receptor 1

References

(Earliest) J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
(Latest) J:194801 Cheng HY, et al., Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):24-32
All references(83)

Other accession IDs

MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243