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Lpar1 Gene Detail
Summary
  • Symbol
    Lpar1
  • Name
    lysophosphatidic acid receptor 1
  • Synonyms
    Edg2, Gpcr26, Kdt2, LPA1, vzg-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108429
    NCBI Gene: 14745
  • Gene Overview
    MyGene.info: LPAR1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:58435255-58553898 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118644 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 32.20 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPAR1, lysophosphatidic acid receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1, VZG1
  • Links
    NCBI Gene ID: 1902
    neXtProt AC: NX_Q92633
    UniProt: Q92633

  • Chr Location
    9q31.3; chr9:110873252-111039259 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations cause partial peri- and postnatal lethality, growth defects, craniofacial anomalies, and wide set eyes. Additional phenotypes include altered brain 5-HT and amino acids, reduced prepulse inhibition, impaired suckling, and increased apoptosis in sciatic nerve Schwann cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000007519 VEGA Gene Model | MGI Sequence Detail 118644 C57BL/6J ±  kb
    transcript OTTMUST00000017338 VEGA | MGI Sequence Detail 3512 Not Applicable  
    polypeptide OTTMUSP00000008010 VEGA | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      792 from dbSNP Build 142
    • PCR
    Protein
    Information
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    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 30
      cDNA 69
      Primer pair 8
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26047, MGD-MRK-37473, MGI:104610, MGI:2140243
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:26723 Thompson HA, et al., Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology. 1995 Jul;136(7):3037-45
    • Latest
      J:263937 Magkrioti C, et al., The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis. Cancer Res. 2018 Jul 1;78(13):3634-3644

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory