Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lox

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LOX
- Mouse genes Lox
- Rat genes Lox
- Zfish genes loxa
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lox

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	LOX	IDA		Human	PMID:31152061
Molecular Function	GO:0005507	copper ion binding	Lox	IMP		Rat	PMID:16432278\|RGD:1600669
Molecular Function	GO:0060090	molecular adaptor activity	LOX	IPI	ChEBI:16336,ChEBI:18376,ChEBI:28304,ChEBI:28815,ChEBI:37397	Human	PMID:30082873
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:O95967	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:P15502	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:P35555	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:Q9UBX5	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:O95967	Human	PMID:19855011
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:Q15262	Human	PMID:21690299
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:O95967	Human	PMID:22919265
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:Q9UBX5	Human	PMID:25118846
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:P55083	Human	PMID:26601954
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:O95967	Human	PMID:27339457
Molecular Function	GO:0005515	protein binding	LOX	IPI	UniProtKB:P00747,UniProtKB:P01133,UniProtKB:P02452,UniProtKB:P02751,UniProtKB:P08123,UniProtKB:P08253,UniProtKB:P12109,UniProtKB:P13605,UniProtKB:P15502,UniProtKB:P21980,UniProtKB:Q07507,UniProtKB:Q14766,UniProtKB:Q9H6X2-2,UniProtKB:Q9Y4K0	Human	PMID:30082873
Molecular Function	GO:0005515	protein binding	Lox	IPI	UniProtKB:Q6UY14\|UniProtKB:Q7TSK7\|UniProtKB:Q9H324	Mouse	MGI:MGI:6313570\|PMID:29758265
Molecular Function	GO:0005515	protein binding	Lox	IPI	UniProtKB:P04049\|UniProtKB:P17879	Mouse	MGI:MGI:5008506\|PMID:21536655
Molecular Function	GO:0005515	protein binding	Lox	IPI	PR:P28301	Mouse	PMID:18835815
Molecular Function	GO:0005515	protein binding	Lox	IPI	PR:Q9WVJ9	Mouse	PMID:19855011
Molecular Function	GO:0005515	protein binding	Lox	IPI	PR:P54320	Mouse	PMID:16251195
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	LOX	IDA		Human	PMID:31152061
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IDA		Mouse	MGI:MGI:5816638\|PMID:27432961
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IDA		Mouse	PMID:16192629
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IDA		Mouse	PMID:14140
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IDA		Mouse	PMID:20889
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IDA		Mouse	PMID:14741400
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IMP		Rat	PMID:16432278\|RGD:1600669
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity	Lox	IDA		Rat	PMID:16804742\|RGD:1600668
Molecular Function	GO:0036094	small molecule binding	LOX	IPI	ChEBI:16336,ChEBI:18376,ChEBI:28304,ChEBI:28815,ChEBI:37397	Human	PMID:30082873
Cellular Component	GO:0005581	collagen trimer	Lox	IDA		Mouse	PMID:7901452
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Lox	HDA		Mouse	MGI:MGI:6201834\|PMID:22159717
Cellular Component	GO:0031012	extracellular matrix	Lox	IDA		Mouse	PMID:25715398
Cellular Component	GO:0031012	extracellular matrix	Lox	IDA		Mouse	PMID:9382709
Cellular Component	GO:0031012	extracellular matrix	Lox	IDA		Mouse	PMID:18835815
Cellular Component	GO:0031012	extracellular matrix	Lox	IDA		Rat	PMID:16251195\|RGD:8553592
Cellular Component	GO:0005576	extracellular region	Lox	IDA		Mouse	MGI:MGI:5816638\|PMID:27432961
Cellular Component	GO:0005615	extracellular space	LOX	IDA		Human	PMID:31152061
Cellular Component	GO:0005615	extracellular space	Lox	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005634	nucleus	Lox	IDA		Rat	PMID:10996848\|RGD:1581906
Biological Process	GO:0035904	aorta development	Lox	IMP		Mouse	PMID:25807483
Biological Process	GO:0035905	ascending aorta development	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:28550176
Biological Process	GO:0001568	blood vessel development	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:12417550
Biological Process	GO:0048514	blood vessel morphogenesis	Lox	IMP		Mouse	MGI:MGI:5816638\|PMID:27432961
Biological Process	GO:0030282	bone mineralization	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:19458888
Biological Process	GO:0051216	cartilage development	loxa	IMP	ZFIN:ZDB-MRPHLNO-080921-2	Zfish	PMID:18467084
Biological Process	GO:0051216	cartilage development	loxa	IMP	ZFIN:ZDB-MRPHLNO-080921-1	Zfish	PMID:18467084
Biological Process	GO:0060326	cell chemotaxis	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:18586678
Biological Process	GO:0060326	cell chemotaxis	Lox	IMP		Rat	PMID:18586678\|RGD:14390060
Biological Process	GO:1990869	cellular response to chemokine	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:18586678
Biological Process	GO:0071310	cellular response to organic substance	Lox	IDA		Mouse	PMID:28800626
Biological Process	GO:0030199	collagen fibril organization	Lox	IMP		Mouse	PMID:26700732
Biological Process	GO:0030199	collagen fibril organization	Lox	IMP		Rat	PMID:16432278\|RGD:1600669
Biological Process	GO:0030199	collagen fibril organization	Lox	IDA		Rat	PMID:16804742\|RGD:1600668
Biological Process	GO:0061448	connective tissue development	Lox	IGI	MGI:MGI:98725	Mouse	PMID:25715398
Biological Process	GO:0035906	descending aorta development	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:28550176
Biological Process	GO:0071897	DNA biosynthetic process	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:19458888
Biological Process	GO:0048251	elastic fiber assembly	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:12417550
Biological Process	GO:0048251	elastic fiber assembly	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:16192629
Biological Process	GO:0048251	elastic fiber assembly	Lox	IMP		Mouse	PMID:23413430
Biological Process	GO:0048251	elastic fiber assembly	Lox	IMP		Rat	PMID:16432278\|RGD:1600669
Biological Process	GO:0007507	heart development	Lox	IMP		Mouse	PMID:25807483
Biological Process	GO:0030324	lung development	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:16192629
Biological Process	GO:0046716	muscle cell cellular homeostasis	Lox	IGI	MGI:MGI:98725	Mouse	PMID:25715398
Biological Process	GO:0055001	muscle cell development	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:25715398
Biological Process	GO:0007517	muscle organ development	loxa	IMP	ZFIN:ZDB-MRPHLNO-080921-2	Zfish	PMID:18467084
Biological Process	GO:0007517	muscle organ development	loxa	IMP	ZFIN:ZDB-MRPHLNO-080921-1	Zfish	PMID:18467084
Biological Process	GO:0022008	neurogenesis	loxa	IMP	ZFIN:ZDB-MRPHLNO-080921-2	Zfish	PMID:18467084
Biological Process	GO:0022008	neurogenesis	loxa	IMP	ZFIN:ZDB-MRPHLNO-080921-1	Zfish	PMID:18467084
Biological Process	GO:0001649	osteoblast differentiation	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:19458888
Biological Process	GO:0018057	peptidyl-lysine oxidation	LOX	IDA		Human	PMID:31152061
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:18586678
Biological Process	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	Lox	IMP		Rat	PMID:18586678\|RGD:14390060
Biological Process	GO:0043491	protein kinase B signaling	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:28538980
Biological Process	GO:0043491	protein kinase B signaling	Lox	IDA		Mouse	PMID:28538980
Biological Process	GO:0018158	protein oxidation	Lox	IMP		Rat	PMID:18586678\|RGD:14390060
Biological Process	GO:0042981	regulation of apoptotic process	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:28538980
Biological Process	GO:1903010	regulation of bone development	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:21665949
Biological Process	GO:0010468	regulation of gene expression	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:28285904
Biological Process	GO:0045652	regulation of megakaryocyte differentiation	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:21665949
Biological Process	GO:2000586	regulation of platelet-derived growth factor receptor-beta signaling pathway	Lox	IMP	MGI:MGI:2657016	Mouse	PMID:21665949
Biological Process	GO:0001932	regulation of protein phosphorylation	Lox	IMP		Mouse	PMID:18835815
Biological Process	GO:1900120	regulation of receptor binding	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:18586678
Biological Process	GO:1900120	regulation of receptor binding	Lox	IMP		Rat	PMID:18586678\|RGD:14390060
Biological Process	GO:0016202	regulation of striated muscle tissue development	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:25715398
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Lox	IMP	MGI:MGI:3610732	Mouse	PMID:25715398
Biological Process	GO:0009725	response to hormone	Lox	IDA		Rat	PMID:12488341\|RGD:729248
Biological Process	GO:0048545	response to steroid hormone	Lox	IDA		Rat	PMID:12488341\|RGD:729248
Biological Process	GO:0009410	response to xenobiotic stimulus	Lox	IEP		Rat	PMID:15816421\|RGD:1581902
Biological Process	GO:0042060	wound healing	Lox	IEP		Rat	PMID:15816421\|RGD:1581902
Biological Process	GO:0042060	wound healing	Lox	IMP		Rat	PMID:16804742\|RGD:1600668

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.