Lox
Gene Detail

Symbol Name ID

Lox lysyl oxidase MGI:96817

Synonyms

ras recision gene (rrg), TSC-160

Feature Type

protein coding gene

Genetic Map

Chromosome 18

28.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr18:52517238-52529708 bp, - strand From NCBI annotation of GRCm38   12471 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein-lysine 6-oxidase
Gene Tree: Lox

Human homologs

Human Homolog		LOX, lysyl oxidase
NCBI Gene ID		4015
neXtProt AC		NX_P28300
Human Chr (Location)		5q23.2; chr5:121398890-121414055 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Homozygous mutation of this gene results in perinatal lethality, aneurysms, hernia or rupture of the diaphragm, and abnormal aorta and aorta elastic fiber morphology.

 
Human Diseases Modeled Using Mouse Lox (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(14)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	blood vessel development, collagen fibril organization, ...
Component	collagen, extracellular region, ...
Function	copper ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (97)    Tissues (96)    Images (11)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	95
RT-PCR	2

cDNA source data(119)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(132) Genomic(9) cDNA(120) Primer pair(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024529 (Evidence)
Entrez Gene	16948 (Evidence)
UniGene	172
DFCI	TC1572418, TC1602062, TC1660725
DoTS	DT.533823, DT.94139675, DT.94303779
NIA Mouse Gene Index	U038427
EC	1.4.3.13
Consensus CDS Project	CCDS50289.1
International Mouse Knockout Project Status	Lox

Sequences

Length	Strain/Species
genomic	16948	NCBI Gene Model | MGI Sequence Detail	12471	C57BL/6J
transcript	NM_010728	RefSeq | MGI Sequence Detail	3604	C57BL/6
polypeptide	P28301	UniProt | EBI | MGI Sequence Detail	411	Not Applicable

All sequences(46) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001695	Lysyl oxidase
InterPro	IPR019828	Lysyl oxidase, conserved site
Protein Ontology	PR:000009883	protein-lysine 6-oxidase

Graphical View of Protein Domain Structure

References

(Earliest) J:5777 Rowe DW, et al., Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem. 1977 Feb 10;252(3):939-42
(Latest) J:189252 Tao G, et al., Collagen XIV is important for growth and structural integrity of the myocardium. J Mol Cell Cardiol. 2012 Nov;53(5):626-38
All references(70)

Other accession IDs

MGD-MRK-11866, MGI:2147282