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Lox
Gene Detail
Symbol

Name
ID
Lox
lysyl oxidase
MGI:96817
Synonyms
ras recision gene (rrg), TSC-160
Feature Type
protein coding gene
Genetic Map
Chromosome 18
28.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr18:52516069-52529867 bp, - strand
From Ensembl annotation of GRCm38

  13799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LOX
Protein SuperFamily: protein-lysine 6-oxidase
Gene Tree: Lox

Human
homologs
LOX, lysyl oxidase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4015
neXtProt AC: NX_P28300

Human Chr (Location): 5q23.2; chr5:122063195-122078360 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous inactivation of this gene leads to altered arterial wall structure, aortic aneurysms, cardiovascular dysfunction, diaphragmatic hernia, and perinatal death. Abnormal development of the respiratory system, and elastic and collagen fiber abnormalities in the lung and skin are also observed.
 
Human Diseases Modeled in Mice Using Lox (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(14)
Interactions
Lox interacts with 332 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process blood vessel development, collagen fibril organization, ...
Component collagen trimer, extracellular region, ...
Function copper ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (99)    Tissues (97)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
RT-PCR 4
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lox ; ZFIN lox    NEW 
Molecular
reagents
All nucleic(47) Genomic(9) cDNA(34) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024529 (Evidence)
Entrez Gene 16948 (Evidence)
DFCI TC1572418, TC1602062, TC1660725, TC1701133
DoTS DT.533823, DT.94139675, DT.94303779, DT.97333987
NIA Mouse Gene Index U038427
EC 1.4.3.13
Consensus CDS Project CCDS50289.1
International Mouse Phenotyping Consortium Status Lox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024529 Ensembl Gene Model | MGI Sequence Detail 13799 C57BL/6J ±  kb
transcript ENSMUST00000025409 Ensembl | MGI Sequence Detail 3604 Not Applicable 
polypeptide ENSMUSP00000025409 Ensembl | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001695 Lysyl oxidase
InterPro IPR019828 Lysyl oxidase, conserved site
Protein Ontology PR:000009883 protein-lysine 6-oxidase
References
(Earliest) J:5777 Rowe DW, et al., Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem. 1977 Feb 10;252(3):939-42
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(73)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11866, MGI:2147282

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory