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Lox Gene Detail
Summary
  • Symbol
    Lox
  • Name
    lysyl oxidase
  • Synonyms
    ras recision gene (rrg), TSC-160
  • Feature Type
    protein coding gene
  • IDs
    MGI:96817
    NCBI Gene: 16948
  • Gene Overview
    MyGene.info: LOX
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:52516069-52529867 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 28.22 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96817
protein coding gene Chr18:52516060-52529867 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024428
protein coding gene Chr18:51638733-51653070 (-)
A/J MGP_AJ_G0024394
protein coding gene Chr18:49648230-49661689 (-)
AKR/J MGP_AKRJ_G0024364
protein coding gene Chr18:51040840-51054769 (-)
BALB/cJ MGP_BALBcJ_G0024394
protein coding gene Chr18:49815911-49842815 (-)
C3H/HeJ MGP_C3HHeJ_G0024161
protein coding gene Chr18:51170277-51185918 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024840
protein coding gene Chr18:53381212-53398983 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022272
protein coding gene Chr18:49452370-49465856 (-)
CAST/EiJ MGP_CASTEiJ_G0023635
protein coding gene Chr18:51119195-51147601 (-)
CBA/J MGP_CBAJ_G0024131
protein coding gene Chr18:54943940-54963912 (-)
DBA/2J MGP_DBA2J_G0024261
protein coding gene Chr18:49354662-49369171 (-)
FVB/NJ MGP_FVBNJ_G0024228
protein coding gene Chr18:48789128-48802786 (-)
LP/J MGP_LPJ_G0024346
protein coding gene Chr18:51665231-51680018 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024258
protein coding gene Chr18:56706334-56721188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024887
protein coding gene Chr18:51051490-51066469 (-)
PWK/PhJ MGP_PWKPhJ_G0023379
protein coding gene Chr18:49373671-49390735 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023185
protein coding gene Chr18:51221726-51256588 (-)
WSB/EiJ MGP_WSBEiJ_G0023698
protein coding gene Chr18:50961232-50977540 (-)



Homology
more
  • Human Ortholog
    LOX, lysyl oxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LOX, lysyl oxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAT10
  • Links
    NCBI Gene ID: 4015
    neXtProt AC: NX_P28300
    UniProt: P28300

  • Chr Location
    5q23.1; chr5:122063195-122078501 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Lox mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 3 genetic backgrounds
    14 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to altered arterial wall structure, aortic aneurysms, cardiovascular dysfunction, diaphragmatic hernia, and perinatal death. Abnormal development of the respiratory system, and elastic and collagen fiber abnormalities in the lung and skin are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024529 Ensembl Gene Model | MGI Sequence Detail 13799 C57BL/6J ±  kb
    transcript ENSMUST00000025409 Ensembl | MGI Sequence Detail 3604 Not Applicable  
    polypeptide ENSMUSP00000025409 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 9
      cDNA 36
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11866, MGI:2147282
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 20
      Phenotypes 13
    • Earliest
      J:5777 Rowe DW, et al., Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem. 1977 Feb 10;252(3):939-42
    • Latest
      J:254644 Kim D, et al., Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2725-2731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory