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Lox Gene Detail
Summary
  • Symbol
    Lox
  • Name
    lysyl oxidase
  • Synonyms
    ras recision gene (rrg), TSC-160
  • Feature Type
    protein coding gene
  • IDs
    MGI:96817
    NCBI Gene: 16948
  • Gene Overview
    MyGene.info: LOX
Location & Maps
more
  • Sequence Map
    Chr18:52516069-52529867 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13799 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 28.22 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    LOX, lysyl oxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LOX, lysyl oxidase
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 4015
    neXtProt AC: NX_P28300

  • Chr Location
    5q23.2; chr5:122063195-122078360 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Lox mouse models

Human Disease Mouse Models
       Menkes Disease   OMIM: 309400 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 3 genetic backgrounds
    14 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Targeted
    3
  • Incidental Mutations
Homozygous inactivation of this gene leads to altered arterial wall structure, aortic aneurysms, cardiovascular dysfunction, diaphragmatic hernia, and perinatal death. Abnormal development of the respiratory system, and elastic and collagen fiber abnormalities in the lung and skin are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024529 Ensembl Gene Model | MGI Sequence Detail 13799 C57BL/6J ±  kb
transcript ENSMUST00000171470 Ensembl | MGI Sequence Detail 4468 Not Applicable  
polypeptide ENSMUSP00000129247 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    81 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    Genomic 9
    cDNA 35
    Primer pair 5

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11866, MGI:2147282
References
more
  • Summaries
    All 71
    Developmental Gene Expression 17
    Diseases 1
    Gene Ontology 15
    Phenotypes 11
  • Earliest
    J:5777 Rowe DW, et al., Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem. 1977 Feb 10;252(3):939-42
  • Latest
    J:222443 Mammoto T, et al., Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. Dev Dyn. 2015 Jun;244(6):713-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory