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Lox
Gene Detail
 Symbol
Name
ID
Lox
lysyl oxidase
MGI:96817
Synonyms ras recision gene (rrg), TSC-160
Feature Type protein coding gene
Genetic Map
Chromosome 18
28.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr18:52517238-52529708 bp, - strand
From NCBI annotation of GRCm38

  12471 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein-lysine 6-oxidase
Gene Tree: Lox

Human
homologs
Human Homolog LOX, lysyl oxidase
NCBI Gene ID 4015
neXtProt AC  NX_P28300
Human Chr (Location)  5q23.2; chr5:122063195-122078360 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to altered arterial wall structure, aortic aneurysms, cardiovascular dysfunction, diaphragmatic hernia, and perinatal death. Abnormal development of the respiratory system, and elastic and collagen fiber abnormalities in the lung and skin are also observed.
 
Human Diseases Modeled Using Mouse Lox (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(14)
Interactions
Lox interacts with 333 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process blood vessel development, collagen fibril organization, ...
Component collagen trimer, extracellular region, ...
Function copper ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (99)    Tissues (97)    Images (12)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 95
RT-PCR 4
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(9) cDNA(34) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024529 (Evidence)
Entrez Gene16948 (Evidence)
DFCITC1572418, TC1602062, TC1660725, TC1701133
DoTSDT.533823, DT.94139675, DT.94303779, DT.97333987
NIA Mouse Gene IndexU038427
EC1.4.3.13
Consensus CDS ProjectCCDS50289.1
International Mouse Knockout Project StatusLox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16948 NCBI Gene Model | MGI Sequence Detail 12471 C57BL/6J ±  kb
transcript NM_010728 RefSeq | MGI Sequence Detail 4914 C57BL/6 
polypeptide P28301 UniProt | EBI | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001695 Lysyl oxidase
InterPro IPR019828 Lysyl oxidase, conserved site
Protein Ontology PR:000009883 protein-lysine 6-oxidase
Graphical View of Protein Domain Structure
References (Earliest) J:5777 Rowe DW, et al., Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem. 1977 Feb 10;252(3):939-42
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(70)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11866, MGI:2147282

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory