Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein-lysine 6-oxidase activity. Involved in blood vessel morphogenesis. Acts upstream of or within several processes, including circulatory system development; extracellular matrix organization; and regulation of signal transduction. Located in extracellular matrix and extracellular region. Part of collagen trimer. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Menkes disease and Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase).