Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRF4
  • Mouse genes Irf4
  • Rat genes Irf4
  • Zfish genes irf4a,irf4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Irf4	IMP		Mouse	MGI:MGI:6269211|PMID:30413670
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IRF4	IDA		Human	PMID:12374808
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	irf4a	IDA		Zfish	PMID:26300447
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Irf4	IDA		Mouse	MGI:MGI:5448096|PMID:22983707
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Irf4	IDA		Mouse	MGI:MGI:5444779|PMID:22992523
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Irf4	IDA		Mouse	MGI:MGI:5441724|PMID:22992524
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	irf4a	IDA		Zfish	PMID:26300447
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:O95163	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:P51617	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:Q86UE8	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:Q9H6S0	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:Q7Z6J9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:Q8TF65	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	IRF4	IPI	UniProtKB:P17947	Human	PMID:33951726
Molecular Function	GO:0005515	protein binding	Irf4	IPI	UniProtKB:O70343	Mouse	MGI:MGI:5603501|PMID:24995979
Molecular Function	GO:0005515	protein binding	Irf4	IPI	UniProtKB:Q8R4B8	Mouse	MGI:MGI:5689221|PMID:26098997
Molecular Function	GO:0005515	protein binding	Irf4	IPI	UniProtKB:O35284	Mouse	MGI:MGI:5441724|PMID:22992524
Molecular Function	GO:0005515	protein binding	Irf4	IPI	UniProtKB:O35284|UniProtKB:P09450|UniProtKB:Q64287	Mouse	MGI:MGI:5444779|PMID:22992523
Molecular Function	GO:0005515	protein binding	Irf4	IPI	UniProtKB:O35284	Mouse	MGI:MGI:5444043|PMID:23021777
Molecular Function	GO:0005515	protein binding	Irf4	IPI	UniProtKB:O35284	Mouse	MGI:MGI:5448096|PMID:22983707
Molecular Function	GO:0005515	protein binding	Irf4	IPI	PR:P22366	Mouse	PMID:16236719
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IRF4	IDA		Human	PMID:12374808
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	irf4a	IDA		Zfish	PMID:26300447
Molecular Function	GO:0043565	sequence-specific DNA binding	Irf4	IDA		Mouse	MGI:MGI:5444779|PMID:22992523
Molecular Function	GO:0043565	sequence-specific DNA binding	Irf4	IDA		Mouse	MGI:MGI:5441724|PMID:22992524
Molecular Function	GO:0043565	sequence-specific DNA binding	Irf4	IDA		Mouse	MGI:MGI:5448096|PMID:22983707
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF4	IDA		Human	PMID:28473536
Molecular Function	GO:0003713	transcription coactivator activity	Irf4	IDA		Mouse	MGI:MGI:6269211|PMID:30413670
Cellular Component	GO:0000785	chromatin	irf4a	IDA		Zfish	PMID:26300447
Cellular Component	GO:0005829	cytosol	IRF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	IRF4	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	IRF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000786	nucleosome	Irf4	IDA		Mouse	PMID:16428437
Cellular Component	GO:0005634	nucleus	irf4a	IDA		Zfish	PMID:25735871
Biological Process	GO:0006338	chromatin remodeling	Irf4	IMP		Mouse	PMID:16428437
Biological Process	GO:0042832	defense response to protozoan	Irf4	IMP		Mouse	MGI:MGI:5441724|PMID:22992524
Biological Process	GO:0097535	lymphoid lineage cell migration into thymus	irf4a	IMP	ZFIN:ZDB-MRPHLNO-160115-2	Zfish	PMID:26300447
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	irf4a	IMP	ZFIN:ZDB-MRPHLNO-160115-2	Zfish	PMID:26300447
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Irf4	IMP		Mouse	MGI:MGI:5441724|PMID:22992524
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Irf4	IMP	MGI:MGI:2387941	Mouse	PMID:15184678
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	irf4a	IMP	ZFIN:ZDB-MRPHLNO-160115-2	Zfish	PMID:26300447
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Irf4	IMP	MGI:MGI:2387941	Mouse	PMID:16236719
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Irf4	IMP		Mouse	MGI:MGI:5603501|PMID:24995979
Biological Process	GO:0043388	positive regulation of DNA binding	Irf4	IMP		Mouse	PMID:16428437
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IRF4	IDA		Human	PMID:12374808
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf4	IGI	UniProtKB:P17433	Mouse	MGI:MGI:5922877|PMID:28338898
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Irf4	IDA		Mouse	MGI:MGI:6269211|PMID:30413670
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IRF4	IDA		Human	PMID:12374808
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IRF4	IDA		Human	PMID:12374808
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IRF4	IDA		Human	PMID:12374808
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IRF4	IDA		Human	PMID:12374808
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF4	IDA		Human	PMID:12374808
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf4	IMP		Mouse	PMID:16428437
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	Irf4	IMP		Mouse	MGI:MGI:5448096|PMID:22983707

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern