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Irf4
Gene Detail
Symbol

Name
ID
Irf4
interferon regulatory factor 4
MGI:1096873
Synonyms
IRF-4, Spip
Feature Type
protein coding gene
Genetic Map
Chromosome 13
13.28 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:30749226-30766927 bp, + strand
From VEGA annotation of GRCm38

  17702 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRF4
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf4

Human
homologs
IRF4, interferon regulatory factor 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3662
neXtProt AC: NX_Q15306

Human Synonyms: LSIRF, MUM1, NF-EM5, SHEP8

Human Chr (Location): 6p25-p23; chr6:391739-411443 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(4)
Genomic Mutations involving Irf4 (1)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections.
 
Interactions
Irf4 interacts with 332 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process defense response to protozoan, histone H3 acetylation, ...
Component cytoplasm, membrane, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (145)    Tissues (144)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
Western blot 1
RT-PCR 1
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN irf4a    NEW 
Molecular
reagents
All nucleic(40) Genomic(1) cDNA(38) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000722 (Evidence)
Ensembl Gene Model ENSMUSG00000021356 (Evidence)
Entrez Gene 16364 (Evidence)
UniGene 4677
DFCI TC1580727, TC1656423
DoTS DT.99858673
NIA Mouse Gene Index U014696
Consensus CDS Project CCDS26419.1
International Mouse Phenotyping Consortium Status Irf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000722 VEGA Gene Model | MGI Sequence Detail 17702 C57BL/6J ±  kb
transcript OTTMUST00000001355 VEGA | MGI Sequence Detail 4715 Not Applicable 
polypeptide OTTMUSP00000000638 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002046 interferon regulatory factor 4
References
(Earliest) J:26104 Eisenbeis CF, et al., Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995 Jun 1;9(11):1377-87
(Latest) J:218674 Carotta S, et al., The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation. J Exp Med. 2014 Oct 20;211(11):2169-81
All references(124)
Other
accession IDs
MGD-MRK-29048, MGI:104895, MGI:2145221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory