Irf4
Gene Detail

Symbol Name ID

Irf4 interferon regulatory factor 4 MGI:1096873

Synonyms

IRF-4, Spip

Feature Type

protein coding gene

Genetic Map

Chromosome 13

13.28 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:30749226-30766927 bp, + strand From VEGA annotation of GRCm38   17702 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf4

Human homologs

Human Homolog		IRF4, interferon regulatory factor 4
NCBI Gene ID		3662
neXtProt AC		NX_Q15306
Human Synonyms		LSIRF, MUM1, NF-EM5
Human Chr (Location)		6p25-p23; chr6:391739-411443 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IRF4

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	defense response to protozoan, histone H3 acetylation, ...
Component	cytoplasm, nuclear nucleosome, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (145)    Tissues (143)    Images (7)
Theiler Stages: 15, 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	143
Western blot	1
RT-PCR	1

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(1) cDNA(38) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000722 (Evidence)
Ensembl Gene Model	ENSMUSG00000021356 (Evidence)
Entrez Gene	16364 (Evidence)
UniGene	4677
DFCI	TC1580727, TC1656423
DoTS	DT.99858673
NIA Mouse Gene Index	U014696
Consensus CDS Project	CCDS26419.1
International Mouse Knockout Project Status	Irf4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000722	VEGA Gene Model | MGI Sequence Detail	17702	C57BL/6J
transcript	OTTMUST00000001355	VEGA | MGI Sequence Detail	4715	Not Applicable
polypeptide	OTTMUSP00000000638	VEGA | MGI Sequence Detail	450	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019471	Interferon regulatory factor-3
InterPro	IPR019817	Interferon regulatory factor, conserved site
InterPro	IPR001346	Interferon regulatory factor DNA-binding domain
InterPro	IPR017855	SMAD domain-like
InterPro	IPR008984	SMAD/FHA domain
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000002046	interferon regulatory factor 4

References

(Earliest) J:26104 Eisenbeis CF, et al., Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995 Jun 1;9(11):1377-87
(Latest) J:193851 Visekruna A, et al., Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur J Immunol. 2013 Mar;43(3):606-18
All references(100)

Other accession IDs

MGD-MRK-29048, MGI:104895, MGI:2145221