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Irf4 Gene Detail
Summary
  • Symbol
    Irf4
  • Name
    interferon regulatory factor 4
  • Synonyms
    IRF-4, Spip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096873
    NCBI Gene: 16364
  • Gene Overview
    MyGene.info: IRF4
Location & Maps
more
  • Sequence Map
    Chr13:30749226-30766927 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17702 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IRF4, interferon regulatory factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRF4, interferon regulatory factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LSIRF, MUM1, NF-EM5, SHEP8
  • Links
    NCBI Gene ID: 3662
    neXtProt AC: NX_Q15306

  • Chr Location
    6p25.3; chr6:391739-411443 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Irf4
  • Incidental Mutations
    APF , CvDC
Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000722 VEGA Gene Model | MGI Sequence Detail 17702 C57BL/6J ±  kb
transcript OTTMUST00000001355 VEGA | MGI Sequence Detail 4715 Not Applicable  
polypeptide OTTMUSP00000000638 VEGA | MGI Sequence Detail 450 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000002046 interferon regulatory factor 4
  • PDB
  • InterPro Domains
    IPR019471 Interferon regulatory factor-3
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR017855 SMAD domain-like
    IPR008984 SMAD/FHA domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 40
    Genomic 1
    cDNA 38
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-29048, MGI:104895, MGI:2145221
References
more
  • Summaries
    All 130
    Developmental Gene Expression 10
    Gene Ontology 13
    Phenotypes 83
  • Earliest
    J:26104 Eisenbeis CF, et al., Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995 Jun 1;9(11):1377-87
  • Latest
    J:230709 Loschko J, et al., Inducible targeting of cDCs and their subsets in vivo. J Immunol Methods. 2016 Apr 9;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory