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Irf4
Gene Detail
Symbol

Name
ID
Irf4
interferon regulatory factor 4
MGI:1096873
Synonyms
IRF-4, Spip
Feature Type
protein coding gene
Genetic Map
Chromosome 13
13.28 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:30749226-30766927 bp, + strand
From VEGA annotation of GRCm38

  17702 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf4

Human
homologs
Human Homolog IRF4, interferon regulatory factor 4
NCBI Gene ID 3662
neXtProt AC  NX_Q15306
Human Synonyms  LSIRF, MUM1, NF-EM5
Human Chr (Location)  6p25-p23; chr6:391739-411443 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IRF4
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections.
 
Interactions
Irf4 interacts with 333 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process defense response to protozoan, histone H3 acetylation, ...
Component membrane, nuclear nucleosome, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (145)    Tissues (144)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
Western blot 1
RT-PCR 1
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(1) cDNA(38) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000722 (Evidence)
Ensembl Gene ModelENSMUSG00000021356 (Evidence)
Entrez Gene16364 (Evidence)
UniGene4677
DFCITC1580727, TC1656423
DoTSDT.99858673
NIA Mouse Gene IndexU014696
Consensus CDS ProjectCCDS26419.1
International Mouse Knockout Project StatusIrf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000722 VEGA Gene Model | MGI Sequence Detail 17702 C57BL/6J ±  kb
transcript OTTMUST00000001355 VEGA | MGI Sequence Detail 4715 Not Applicable 
polypeptide OTTMUSP00000000638 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002046 interferon regulatory factor 4
References
(Earliest) J:26104 Eisenbeis CF, et al., Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995 Jun 1;9(11):1377-87
(Latest) J:213132 Masson F, et al., Id2 represses E2A-mediated activation of IL-10 expression in T cells. Blood. 2014 May 29;123(22):3420-8
All references(122)
Other
accession IDs
MGD-MRK-29048, MGI:104895, MGI:2145221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory