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Irf4 Gene Detail
Summary
  • Symbol
    Irf4
  • Name
    interferon regulatory factor 4
  • Synonyms
    IRF-4, Spip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096873
    NCBI Gene: 16364
  • Gene Overview
    MyGene.info: IRF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:30749226-30766927 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17702 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.28 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IRF4, interferon regulatory factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRF4, interferon regulatory factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LSIRF, MUM1, NF-EM5, SHEP8
  • Links
    NCBI Gene ID: 3662
    neXtProt AC: NX_Q15306
    UniProt: Q15306

  • Chr Location
    6p25.3; chr6:391739-411443 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 5 alleles in 9 genetic backgrounds
    12 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections as well as impaired thermogenic gene expression and energy expenditure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000722 VEGA Gene Model | MGI Sequence Detail 17702 C57BL/6J ±  kb
    transcript OTTMUST00000001355 VEGA | MGI Sequence Detail 4715 Not Applicable  
    polypeptide OTTMUSP00000000638 VEGA | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      75 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 1
      cDNA 38
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-29048, MGI:104895, MGI:2145221
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 113
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:258422 Lai R, et al., CD11b(+) Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103(+) Dendritic Cells via IL-10. J Immunol. 2018 Mar 1;200(5):1746-1760

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory