Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INSM1
  • Mouse genes Insm1
  • Rat genes
  • Zfish genes insm1a,insm1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Insm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	INSM1	IDA		Human	PMID:16569215
Molecular Function	GO:0031490	chromatin DNA binding	INSM1	IDA		Human	PMID:18417529
Molecular Function	GO:0030332	cyclin binding	INSM1	IPI	UniProtKB:P24385	Human	PMID:16569215
Molecular Function	GO:0030332	cyclin binding	INSM1	IPI	UniProtKB:P24385	Human	PMID:18417529
Molecular Function	GO:0030332	cyclin binding	INSM1	IPI	UniProtKB:P24385	Human	PMID:19124461
Molecular Function	GO:0003700	DNA-binding transcription factor activity	INSM1	IDA		Human	PMID:11842116
Molecular Function	GO:0003700	DNA-binding transcription factor activity	INSM1	IDA		Human	PMID:16569215
Molecular Function	GO:0003700	DNA-binding transcription factor activity	INSM1	IDA		Human	PMID:18417529
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	insm1a	IMP		Zfish	PMID:30606747
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	INSM1	IDA		Human	PMID:16569215
Molecular Function	GO:0042826	histone deacetylase binding	INSM1	IPI	UniProtKB:O15379	Human	PMID:16569215
Molecular Function	GO:0042826	histone deacetylase binding	INSM1	IPI	UniProtKB:Q13547	Human	PMID:16569215
Molecular Function	GO:0042826	histone deacetylase binding	INSM1	IPI	UniProtKB:O15379	Human	PMID:18417529
Molecular Function	GO:0060090	molecular adaptor activity	INSM1	EXP		Human	PMID:23721412
Molecular Function	GO:0005515	protein binding	Insm1	IPI	UniProtKB:Q62417	Mouse	MGI:MGI:2182863|PMID:12079283
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	INSM1	IDA		Human	PMID:11842116
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	INSM1	IDA		Human	PMID:16569215
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	INSM1	IDA		Human	PMID:18417529
Molecular Function	GO:0043565	sequence-specific DNA binding	insm1a	IPI	ZFIN:ZDB-GENE-060421-4643	Zfish	PMID:23000964
Molecular Function	GO:0043565	sequence-specific DNA binding	insm1a	IPI	ZFIN:ZDB-GENE-990708-5	Zfish	PMID:23000964
Molecular Function	GO:0043565	sequence-specific DNA binding	insm1a	IPI	ZFIN:ZDB-GENE-040426-1810	Zfish	PMID:23000964
Molecular Function	GO:0043565	sequence-specific DNA binding	insm1a	IPI	ZFIN:ZDB-GENE-980526-90	Zfish	PMID:23000964
Molecular Function	GO:0043565	sequence-specific DNA binding	insm1a	IPI	ZFIN:ZDB-GENE-080204-119	Zfish	PMID:23000964
Cellular Component	GO:0005634	nucleus	Insm1	IDA		Mouse	PMID:12079283
Cellular Component	GO:0017053	transcription repressor complex	INSM1	IDA		Human	PMID:16569215
Cellular Component	GO:0017053	transcription repressor complex	INSM1	IDA		Human	PMID:18417529
Biological Process	GO:0061104	adrenal chromaffin cell differentiation	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0043697	cell dedifferentiation	insm1a	IMP	ZFIN:ZDB-MRPHLNO-121017-1	Zfish	PMID:23000964
Biological Process	GO:0043697	cell dedifferentiation	insm1a	IGI	ZFIN:ZDB-GENE-980526-90,ZFIN:ZDB-GENE-990708-5	Zfish	PMID:23000964
Biological Process	GO:0016477	cell migration	Insm1	IMP	MGI:MGI:5576020	Mouse	PMID:25053427
Biological Process	GO:0008283	cell population proliferation	Insm1	IMP	MGI:MGI:5576020	Mouse	PMID:25053427
Biological Process	GO:0031018	endocrine pancreas development	Insm1	IMP		Mouse	PMID:16511571
Biological Process	GO:0035270	endocrine system development	Insm1	IMP	MGI:MGI:3656035	Mouse	PMID:16951258
Biological Process	GO:0008285	negative regulation of cell population proliferation	INSM1	IDA		Human	PMID:19124461
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	insm1a	IDA		Zfish	PMID:23000964
Biological Process	GO:0001933	negative regulation of protein phosphorylation	INSM1	IDA		Human	PMID:19124461
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	INSM1	IDA		Human	PMID:11842116
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	INSM1	IDA		Human	PMID:16569215
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	INSM1	IDA		Human	PMID:18417529
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	INSM1	IDA		Human	PMID:19124461
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	insm1a	IDA		Zfish	PMID:30606747
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	insm1a	IMP		Zfish	PMID:30606747
Biological Process	GO:0003358	noradrenergic neuron development	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0042421	norepinephrine biosynthetic process	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0003310	pancreatic A cell differentiation	Insm1	IDA		Mouse	MGI:MGI:3619850|PMID:16511571
Biological Process	GO:0003310	pancreatic A cell differentiation	Insm1	IMP		Mouse	PMID:16511571
Biological Process	GO:0045597	positive regulation of cell differentiation	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0030335	positive regulation of cell migration	Insm1	IMP	MGI:MGI:5576020	Mouse	PMID:25053427
Biological Process	GO:0008284	positive regulation of cell population proliferation	Insm1	IMP	MGI:MGI:5576020	Mouse	PMID:25053427
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0035677	posterior lateral line neuromast hair cell development	insm1a	IMP	ZFIN:ZDB-MRPHLNO-171018-2	Zfish	PMID:28824372
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	insm1a	IMP	ZFIN:ZDB-MRPHLNO-171018-2	Zfish	PMID:28824372
Biological Process	GO:0051726	regulation of cell cycle	INSM1	IDA		Human	PMID:19124461
Biological Process	GO:0010564	regulation of cell cycle process	insm1a	IMP	ZFIN:ZDB-MRPHLNO-121017-1	Zfish	PMID:23000964
Biological Process	GO:0010468	regulation of gene expression	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0043254	regulation of protein-containing complex assembly	INSM1	IDA		Human	PMID:19124461
Biological Process	GO:0042670	retinal cone cell differentiation	insm1a	IMP	ZFIN:ZDB-MRPHLNO-130920-5	Zfish	PMID:23747542
Biological Process	GO:0042670	retinal cone cell differentiation	insm1a	IMP	ZFIN:ZDB-MRPHLNO-130920-4	Zfish	PMID:23747542
Biological Process	GO:0060221	retinal rod cell differentiation	insm1a	IMP	ZFIN:ZDB-MRPHLNO-130920-5	Zfish	PMID:23747542
Biological Process	GO:0060221	retinal rod cell differentiation	insm1a	IMP	ZFIN:ZDB-MRPHLNO-130920-4	Zfish	PMID:23747542
Biological Process	GO:0070654	sensory epithelium regeneration	insm1a	IGI	ZFIN:ZDB-GENE-980526-90,ZFIN:ZDB-GENE-990708-5	Zfish	PMID:23000964
Biological Process	GO:0070654	sensory epithelium regeneration	insm1a	IGI	ZFIN:ZDB-GENE-080204-119	Zfish	PMID:23000964
Biological Process	GO:0021522	spinal cord motor neuron differentiation	insm1a	IMP	ZFIN:ZDB-CRISPR-170113-5	Zfish	PMID:28894416
Biological Process	GO:0021522	spinal cord motor neuron differentiation	insm1a	IMP	ZFIN:ZDB-MRPHLNO-171018-2	Zfish	PMID:28894416
Biological Process	GO:0061549	sympathetic ganglion development	Insm1	IMP		Mouse	MGI:MGI:3772428|PMID:18094025
Biological Process	GO:0042246	tissue regeneration	insm1a	IDA		Zfish	PMID:30606747
Biological Process	GO:0042246	tissue regeneration	insm1a	IMP		Zfish	PMID:30606747
Biological Process	GO:0060290	transdifferentiation	INSM1	IDA		Human	PMID:16511571
Biological Process	GO:0003323	type B pancreatic cell development	Insm1	IMP	MGI:MGI:3656035	Mouse	PMID:16951258
Biological Process	GO:0003309	type B pancreatic cell differentiation	Insm1	IDA		Mouse	MGI:MGI:3619850|PMID:16511571
Biological Process	GO:0003309	type B pancreatic cell differentiation	Insm1	IMP		Mouse	PMID:16511571

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern