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Insm1
Gene Detail
Symbol

Name
ID
Insm1
insulinoma-associated 1
MGI:1859980
Synonyms
IA-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:146221921-146225020 bp, + strand
From VEGA annotation of GRCm38

  3100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: INSM1
Gene Tree: Insm1

Human
homologs
INSM1, insulinoma-associated 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3642
neXtProt AC: NX_Q01101

Human Synonyms: IA1, IA-1

Human Chr (Location): 20p11.2; chr20:20368121-20370949 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for a null allele display perinatal and neonatal lethality, respiratory failure, and impaired pancreatic and intestinal endocrine cell development.
 
Interactions
Insm1 interacts with 240 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process adrenal chromaffin cell differentiation, cell cycle, ...
Component nucleus, transcriptional repressor complex
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (270)    Tissues (170)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 227
Northern blot 33
RT-PCR 10
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase insm1 ; ZFIN insm1a, insm1b    NEW 
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015694 (Evidence)
Ensembl Gene Model ENSMUSG00000068154 (Evidence)
Entrez Gene 53626 (Evidence)
UniGene 379070
DFCI TC1582723, TC1633725
DoTS DT.101715369, DT.87072851, DT.97403722
NIA Mouse Gene Index U056235
Consensus CDS Project CCDS16830.1
International Mouse Phenotyping Consortium Status Insm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015694 VEGA Gene Model | MGI Sequence Detail 3100 C57BL/6J ±  kb
transcript OTTMUST00000037301 VEGA | MGI Sequence Detail 3100 Not Applicable 
polypeptide OTTMUSP00000016706 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009062 insulinoma-associated protein 1
References
(Earliest) J:68357 Wu J, et al., Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans. Genes Dev. 2001 Mar 15;15(6):789-802
(Latest) J:217584 Gerstmann K, et al., Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. Development. 2015 Jan 1;142(1):140-50
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory