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Insm1 Gene Detail
Summary
  • Symbol
    Insm1
  • Name
    insulinoma-associated 1
  • Synonyms
    IA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859980
    NCBI Gene: 53626
  • Gene Overview
    MyGene.info: INSM1
Location & Maps
more
  • Sequence Map
    Chr2:146221921-146225020 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3100 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 71.33 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    INSM1, INSM transcriptional repressor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INSM1, INSM transcriptional repressor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IA1, IA-1
  • Links
    NCBI Gene ID: 3642
    neXtProt AC: NX_Q01101

  • Chr Location
    20p11.2; chr20:20368121-20370949 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 4 alleles in 7 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Insm1
Mice homozygous for a null allele display perinatal and neonatal lethality, respiratory failure, and impaired pancreatic and intestinal endocrine cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015694 VEGA Gene Model | MGI Sequence Detail 3100 C57BL/6J ±  kb
transcript OTTMUST00000037301 VEGA | MGI Sequence Detail 3100 Not Applicable  
polypeptide OTTMUSP00000016706 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009062 insulinoma-associated protein 1
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 22
    cDNA 19
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 58
    Developmental Gene Expression 33
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:68357 Wu J, et al., Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans. Genes Dev. 2001 Mar 15;15(6):789-802
  • Latest
    J:228519 Jia S, et al., Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1. Dev Biol. 2015 Dec 1;408(1):90-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory