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Insm1
Gene Detail
 Symbol
Name
ID
Insm1
insulinoma-associated 1
MGI:1859980
Synonyms IA-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:146221921-146225020 bp, + strand
From VEGA annotation of GRCm38

  3100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 western clawed frog; 2 zebrafish

Gene Tree: Insm1

Human
homologs
Human Homolog INSM1, insulinoma-associated 1
NCBI Gene ID 3642
neXtProt AC  NX_Q01101
Human Synonyms  IA1, IA-1
Human Chr (Location)  20p11.2; chr20:20368121-20370949 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for a null allele display perinatal and neonatal lethality, respiratory failure, and impaired pancreatic and intestinal endocrine cell development.
 
Interactions
Insm1 interacts with 241 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process adrenal chromaffin cell differentiation, cell cycle, ...
Component nucleus, transcriptional repressor complex
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (270)    Tissues (170)    Images (41)
Theiler Stages: 6, 7, 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 227
Northern blot 33
RT-PCR 10
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015694 (Evidence)
Ensembl Gene ModelENSMUSG00000068154 (Evidence)
Entrez Gene53626 (Evidence)
UniGene379070
DFCITC1582723, TC1633725
DoTSDT.101715369, DT.87072851, DT.97403722
NIA Mouse Gene IndexU056235
Consensus CDS ProjectCCDS16830.1
International Mouse Knockout Project StatusInsm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015694 VEGA Gene Model | MGI Sequence Detail 3100 C57BL/6J ±  kb
transcript OTTMUST00000037301 VEGA | MGI Sequence Detail 3100 Not Applicable 
polypeptide OTTMUSP00000016706 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009062 insulinoma-associated protein 1
References (Earliest) J:67331 Tateno M, et al., Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer Res. 2001 Feb 1;61(3):1144-53
(Latest) J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory