Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Il1a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IL1A
- Mouse genes Il1a
- Rat genes Il1a
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Il1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005507	copper ion binding	IL1A	IDA		Human	PMID:12746488
Molecular Function	GO:0005125	cytokine activity	IL1A	IMP		Human	PMID:2989698
Molecular Function	GO:0005125	cytokine activity	Il1a	IDA		Mouse	PMID:23395675
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:Q99584	Human	PMID:12746488
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:O00165	Human	PMID:16971486
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:P27930	Human	PMID:16971486
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:P29466	Human	PMID:18329368
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:P29466:PRO_0000004522	Human	PMID:18329368
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:P27930	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:O00165	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:O60684	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	IL1A	IPI	UniProtKB:P50222	Human	PMID:25910212
Cellular Component	GO:0009986	cell surface	Il1a	IDA		Rat	PMID:17621543\|RGD:2311093
Cellular Component	GO:0005829	cytosol	IL1A	IDA		Human	PMID:12746488
Cellular Component	GO:0005829	cytosol	Il1a	IDA		Rat	PMID:7721336\|RGD:7800678
Cellular Component	GO:0005615	extracellular space	IL1A	IDA		Human	PMID:12746488
Cellular Component	GO:0005615	extracellular space	IL1A	IMP		Human	PMID:3493774
Cellular Component	GO:0005615	extracellular space	Il1a	IDA		Mouse	PMID:21148126
Cellular Component	GO:0005615	extracellular space	Il1a	IDA		Rat	PMID:12270120\|RGD:729411
Cellular Component	GO:0005615	extracellular space	Il1a	IDA		Rat	PMID:19472295\|RGD:8693643
Cellular Component	GO:0005886	plasma membrane	Il1a	IDA		Rat	PMID:7721336\|RGD:7800678
Biological Process	GO:0002526	acute inflammatory response	Il1a	IEP		Rat	PMID:8806881\|RGD:7794765
Biological Process	GO:0034605	cellular response to heat	IL1A	IDA		Human	PMID:12746488
Biological Process	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	Il1a	IMP		Mouse	PMID:15784728
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IL1A	IMP		Human	PMID:2989698
Biological Process	GO:0035234	ectopic germ cell programmed cell death	Il1a	IGI	MGI:MGI:96543	Mouse	PMID:11536012
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Il1a	IMP	MGI:MGI:2157371	Mouse	PMID:11536012
Biological Process	GO:0007507	heart development	Il1a	IEP		Rat	PMID:1297459\|RGD:7794762
Biological Process	GO:0072639	interleukin-33 production	Il1a	IDA		Mouse	PMID:32484881
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Il1a	IDA		Mouse	PMID:19766171
Biological Process	GO:0031424	keratinization	Il1a	IDA		Rat	PMID:20385541\|RGD:4142790
Biological Process	GO:0008285	negative regulation of cell population proliferation	IL1A	IDA		Human	PMID:3493774
Biological Process	GO:1904445	negative regulation of establishment of Sertoli cell barrier	Il1a	IDA		Rat	PMID:18057314\|RGD:10046056
Biological Process	GO:0045766	positive regulation of angiogenesis	Il1a	IMP		Mouse	MGI:MGI:2652930\|PMID:12598651
Biological Process	GO:0001819	positive regulation of cytokine production	IL1A	IDA		Human	PMID:1739124
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Il1a	IDA		Rat	PMID:16595703\|RGD:2311095
Biological Process	GO:0010628	positive regulation of gene expression	IL1A	IDA		Human	PMID:23817958
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Il1a	IDA		Rat	PMID:15671867\|RGD:1358666
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IL1A	IMP		Human	PMID:2989698
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Il1a	IMP		Rat	PMID:31172560\|RGD:15023467
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il1a	IMP		Rat	PMID:31172560\|RGD:15023467
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Il1a	IMP		Rat	PMID:17621543\|RGD:2311093
Biological Process	GO:0046330	positive regulation of JNK cascade	Il1a	IDA		Rat	PMID:15671867\|RGD:1358666
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IL1A	IMP		Human	PMID:2989698
Biological Process	GO:1902624	positive regulation of neutrophil migration	Il1a	IMP		Rat	PMID:1826836\|RGD:7794767
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	Il1a	IDA		Rat	PMID:8612624\|RGD:7800677
Biological Process	GO:0050714	positive regulation of protein secretion	IL1A	IMP		Human	PMID:9564845
Biological Process	GO:0010893	positive regulation of steroid biosynthetic process	Il1a	IDA		Rat	PMID:16595703\|RGD:2311095
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Il1a	IDA		Rat	PMID:15671867\|RGD:1358666
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il1a	IGI	MGI:MGI:1932410	Mouse	PMID:19666510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il1a	IGI	MGI:MGI:107364	Mouse	PMID:19666510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il1a	IGI	MGI:MGI:1890474	Mouse	PMID:19666510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Il1a	IGI	MGI:MGI:96543	Mouse	PMID:19666510
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Il1a	IMP		Rat	PMID:31172560\|RGD:15023467
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	Il1a	IMP		Mouse	MGI:MGI:2652930\|PMID:12598651
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Il1a	IDA		Rat	PMID:18057314\|RGD:10046056
Biological Process	GO:0051930	regulation of sensory perception of pain	Il1a	IDA		Rat	PMID:18374486\|RGD:2311090
Biological Process	GO:0046688	response to copper ion	IL1A	IDA		Human	PMID:12746488
Biological Process	GO:0010332	response to gamma radiation	Il1a	IEP		Rat	PMID:16524844\|RGD:2311096
Biological Process	GO:0009408	response to heat	Il1a	IEP		Rat	PMID:8178258\|RGD:4142847
Biological Process	GO:0001666	response to hypoxia	Il1a	IEP		Rat	PMID:15197744\|RGD:4143218
Biological Process	GO:0033591	response to L-ascorbic acid	Il1a	IEP		Rat	PMID:18983910\|RGD:2311086
Biological Process	GO:0032496	response to lipopolysaccharide	Il1a	IEP		Rat	PMID:19524137\|RGD:2311077
Biological Process	GO:0014070	response to organic cyclic compound	Il1a	IEP		Rat	PMID:16087301\|RGD:2311097
Biological Process	GO:0014070	response to organic cyclic compound	Il1a	IEP		Rat	PMID:17696279\|RGD:2311102
Biological Process	GO:0010033	response to organic substance	Il1a	IEP		Rat	PMID:15451557\|RGD:2311101
Biological Process	GO:0010243	response to organonitrogen compound	Il1a	IEP		Rat	PMID:15580020\|RGD:2311100
Biological Process	GO:0010193	response to ozone	Il1a	IEP		Rat	PMID:17901407\|RGD:2311091
Biological Process	GO:0007165	signal transduction	Il1a	IDA		Mouse	MGI:MGI:5468848\|PMID:23395675
Biological Process	GO:0007283	spermatogenesis	Il1a	IEP		Rat	PMID:7859917\|RGD:7800679
Biological Process	GO:0042060	wound healing	Il1a	IEP		Rat	PMID:18638276\|RGD:2311088

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.