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Il1a
Gene Detail
Symbol

Name
ID
Member of
Il1a
interleukin 1 alpha
MGI:96542
Il1 cluster
Synonyms
Il-1a
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.90 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(57)
Sequence Map
Chr2:129299610-129309972 bp, - strand
From VEGA annotation of GRCm38

  10363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL1A
Protein SuperFamily: interleukin-1
Gene Tree: Il1a

Human
homologs
IL1A, interleukin 1, alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3552
neXtProt AC: NX_P01583

Human Synonyms: IL1, IL-1A, IL1-ALPHA, IL1F1

Human Chr (Location): 2q14; chr2:112773915-112785394 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Il1a interacts with 231 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process cellular response to heat, connective tissue replacement involved in inflammatory response wound healing, ...
Component cell surface, cytosol, ...
Function copper ion binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (108)    Tissues (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 103
Nuclease S1 5
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015415 (Evidence)
Ensembl Gene Model ENSMUSG00000027399 (Evidence)
Entrez Gene 16175 (Evidence)
UniGene 15534
DFCI TC1585770
DoTS DT.55187969, DT.99645818
Consensus CDS Project CCDS16725.1
International Mouse Phenotyping Consortium Status Il1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015415 VEGA Gene Model | MGI Sequence Detail 10363 C57BL/6J ±  kb
transcript OTTMUST00000036603 VEGA | MGI Sequence Detail 1974 Not Applicable 
polypeptide OTTMUSP00000016430 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(14) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR003294 Interleukin-1, alpha/beta
InterPro IPR003295 Interleukin-1, alpha IL1A
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003502 Interleukin-1 propeptide
Protein Ontology PR:000001135 interleukin-1 alpha
References
(Earliest) J:7660 Lomedico PT, et al., Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature. 1984 Nov 29-Dec 5;312(5993):458-62
(Latest) J:219900 Huaux F, et al., IL-1alpha induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation. J Pathol. 2015 Apr;235(5):698-709
All references(233)
Other
accession IDs
MGD-MRK-11351, MGD-MRK-11366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory