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Il1a
Gene Detail
 Symbol
Name
ID
Member of
Il1a
interleukin 1 alpha
MGI:96542
Il1 cluster
Synonyms Il-1a
Feature Type protein coding gene
Genetic Map
Chromosome 2
62.90 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(57)
Sequence Map
Chr2:129299610-129309972 bp, - strand
From VEGA annotation of GRCm38

  10363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-1
Gene Tree: Il1a

Human
homologs
Human Homolog IL1A, interleukin 1, alpha
NCBI Gene ID 3552
neXtProt AC  NX_P01583
Human Synonyms  IL1, IL-1A, IL1-ALPHA, IL1F1
Human Chr (Location)  2q14; chr2:112773915-112785394 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, development of Th2 helper cell responses and some antibody responses are compromised.
 
Interactions
Il1a interacts with 232 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cellular response to heat, cytokine-mediated signaling pathway, ...
Component cell surface, cytosol, ...
Function copper ion binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (108)    Tissues (61)   
Theiler Stages: 2, 3, 4, 5, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RT-PCR 103
Nuclease S1 5
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015415 (Evidence)
Ensembl Gene ModelENSMUSG00000027399 (Evidence)
Entrez Gene16175 (Evidence)
UniGene15534
DFCITC1585770
DoTSDT.55187969, DT.99645818
Consensus CDS ProjectCCDS16725.1
International Mouse Knockout Project StatusIl1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015415 VEGA Gene Model | MGI Sequence Detail 10363 C57BL/6J ±  kb
transcript OTTMUST00000036603 VEGA | MGI Sequence Detail 1974 Not Applicable 
polypeptide OTTMUSP00000016430 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(3)
Polymorphisms RFLP(14) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR003294 Interleukin-1, alpha/beta
InterPro IPR003295 Interleukin-1, alpha IL1A
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003502 Interleukin-1 propeptide
Protein Ontology PR:000001135 interleukin-1 alpha
References (Earliest) J:7660 Lomedico PT, et al., Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature. 1984 Nov 29-Dec 5;312(5993):458-62
(Latest) J:209377 Ikeda S, et al., Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-beta-induced Foxp3 expression. J Immunol. 2014 Feb 15;192(4):1449-58
All references(230)
Other
accession IDs
MGD-MRK-11351, MGD-MRK-11366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory