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Gene Ontology Browser
Term Detail
GO term:keratinization
GO id:GO:0031424
Definition:The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
Number of paths to term: 15

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-aepidermal cell differentiation
                                                                is-akeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aanimal organ development
                                        is-askin development
                                                part-ofkeratinocyte differentiation
                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                part-ofcornification
                                                        part-ofkeratinocyte development +
                                                        is-alimb granular cell differentiation +
                                                        is-alimb spinous cell differentiation +
                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        is-askin development
                                                                part-ofkeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-ofanimal organ development
                                                is-askin development
                                                        part-ofkeratinocyte differentiation
                                                                part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                        part-ofcornification
                                                                part-ofkeratinocyte development +
                                                                is-alimb granular cell differentiation +
                                                                is-alimb spinous cell differentiation +
                                                                negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                positively-regulatespositive regulation of keratinocyte differentiation
                                                                regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-atissue development
                                        is-aepidermis development
                                                part-ofepidermal cell differentiation
                                                        is-akeratinocyte differentiation
                                                                part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                        part-ofcornification
                                                                part-ofkeratinocyte development +
                                                                is-alimb granular cell differentiation +
                                                                is-alimb spinous cell differentiation +
                                                                negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                positively-regulatespositive regulation of keratinocyte differentiation
                                                                regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-atissue development
                                        is-aepithelium development
                                                part-ofepithelial cell differentiation
                                                        is-aepidermal cell differentiation
                                                                is-akeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-aepidermal cell differentiation
                                                                is-akeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        is-askin development
                                                                part-ofkeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-aadult behavior +
                                is-abeta-amyloid clearance +
                                is-abud dormancy process
                                is-acallus formation
                                is-acircadian regulation of gene expression
                                is-acircadian regulation of heart rate +
                                is-acircadian regulation of translation
                                is-acoagulation +
                                is-acytokine production +
                                is-adetermination of adult lifespan +
                                is-adigestion +
                                is-agastric acid secretion +
                                is-ahatching behavior
                                is-ainnervation +
                                is-aintestinal D-glucose absorption +
                                is-aintestinal folate absorption
                                is-aintestinal lipid absorption +
                                is-akeratinization [GO:0031424] (35 genes, 35 annotations)
                                        part-ofcornification
                                is-alarval behavior +
                                is-alearning or memory +
                                is-amegagametogenesis +
                                is-ameristem determinacy +
                                is-ameristem maintenance +
                                is-amicrogametogenesis +
                                is-amidbrain-hindbrain boundary maturation during brain development
                                is-amidbrain-hindbrain boundary maturation during neural plate development
                                is-amolting cycle +
                                is-amolting cycle process +
                                is-amorphogenesis of a branching structure +
                                is-amulticellular organism adhesion +
                                is-amulticellular organism development +
                                is-amulticellular organism growth +
                                is-amulticellular organism metabolic process +
                                is-amulticellular organismal homeostasis +
                                is-amulticellular organismal movement +
                                is-amulticellular organismal response to stress +
                                is-amulticellular organismal signaling +
                                is-amuscle attachment +
                                negatively-regulatesnegative regulation of multicellular organismal process +
                                is-aneurotrophin production +
                                is-aorgan growth +
                                is-aorganism emergence from protective structure +
                                is-aossification +
                                is-aotolith tethering
                                is-apattern specification process +
                                is-aphotoreceptor cell maintenance
                                is-apigment accumulation in tissues +
                                is-aplasma lipoprotein particle clearance +
                                is-aplasma lipoprotein particle organization +
                                is-apollen germination
                                is-apolyphenic determination +
                                positively-regulatespositive regulation of multicellular organismal process +
                                is-apost-embryonic development +
                                is-aprimary growth
                                is-aproduction of molecular mediator involved in inflammatory response +
                                is-apseudocleavage +
                                is-apupariation
                                is-apupation
                                is-arenal glucose absorption
                                is-arenal tubular secretion
                                is-arenal water transport +
                                is-arespiratory gaseous exchange +
                                is-aresponse to dietary excess +
                                is-aresponse to high population density
                                is-ascab formation
                                is-asecretion by tissue +
                                is-aseed dormancy process +
                                is-aseed germination +
                                is-asleep +
                                is-astem cell population maintenance +
                                is-atissue migration +
                                is-atissue remodeling +
                                is-atransforming growth factor beta activation +
                                is-avascular transport +
                                is-avibrational conductance of sound to the inner ear
                                is-avisual behavior +


obsolete Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        is-askin development
                                                                part-ofkeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-aadult behavior +
                                is-abeta-amyloid clearance +
                                is-abud dormancy process
                                is-acallus formation
                                is-acircadian regulation of gene expression
                                is-acircadian regulation of heart rate +
                                is-acircadian regulation of translation
                                is-acoagulation +
                                is-acytokine production +
                                is-adetermination of adult lifespan +
                                is-adigestion +
                                is-agastric acid secretion +
                                is-ahatching behavior
                                is-ainnervation +
                                is-aintestinal D-glucose absorption +
                                is-aintestinal folate absorption
                                is-aintestinal lipid absorption +
                                is-akeratinization [GO:0031424] (35 genes, 35 annotations)
                                        part-ofcornification
                                is-alarval behavior +
                                is-alearning or memory +
                                is-amegagametogenesis +
                                is-ameristem determinacy +
                                is-ameristem maintenance +
                                is-amicrogametogenesis +
                                is-amidbrain-hindbrain boundary maturation during brain development
                                is-amidbrain-hindbrain boundary maturation during neural plate development
                                is-amolting cycle +
                                is-amolting cycle process +
                                is-amorphogenesis of a branching structure +
                                is-amulticellular organism adhesion +
                                is-amulticellular organism development +
                                is-amulticellular organism growth +
                                is-amulticellular organism metabolic process +
                                is-amulticellular organismal homeostasis +
                                is-amulticellular organismal movement +
                                is-amulticellular organismal response to stress +
                                is-amulticellular organismal signaling +
                                is-amuscle attachment +
                                negatively-regulatesnegative regulation of multicellular organismal process +
                                is-aneurotrophin production +
                                is-aorgan growth +
                                is-aorganism emergence from protective structure +
                                is-aossification +
                                is-aotolith tethering
                                is-apattern specification process +
                                is-aphotoreceptor cell maintenance
                                is-apigment accumulation in tissues +
                                is-aplasma lipoprotein particle clearance +
                                is-aplasma lipoprotein particle organization +
                                is-apollen germination
                                is-apolyphenic determination +
                                positively-regulatespositive regulation of multicellular organismal process +
                                is-apost-embryonic development +
                                is-aprimary growth
                                is-aproduction of molecular mediator involved in inflammatory response +
                                is-apseudocleavage +
                                is-apupariation
                                is-apupation
                                is-arenal glucose absorption
                                is-arenal tubular secretion
                                is-arenal water transport +
                                is-arespiratory gaseous exchange +
                                is-aresponse to dietary excess +
                                is-aresponse to high population density
                                is-ascab formation
                                is-asecretion by tissue +
                                is-aseed dormancy process +
                                is-aseed germination +
                                is-asleep +
                                is-astem cell population maintenance +
                                is-atissue migration +
                                is-atissue remodeling +
                                is-atransforming growth factor beta activation +
                                is-avascular transport +
                                is-avibrational conductance of sound to the inner ear
                                is-avisual behavior +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        is-askin development
                                                                part-ofkeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-aepidermal cell differentiation
                                                                is-akeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-aepidermal cell differentiation
                                                                is-akeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        is-askin development
                                                                part-ofkeratinocyte differentiation
                                                                        part-ofkeratinization [GO:0031424] (35 genes, 35 annotations)
                                                                                part-ofcornification
                                                                        part-ofkeratinocyte development +
                                                                        is-alimb granular cell differentiation +
                                                                        is-alimb spinous cell differentiation +
                                                                        negatively-regulatesnegative regulation of keratinocyte differentiation
                                                                        positively-regulatespositive regulation of keratinocyte differentiation
                                                                        regulatesregulation of keratinocyte differentiation +


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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory