| GO term: | keratinization |
| GO id: | GO:0031424 |
| Definition: | The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. |
| Number of paths to term: | 16 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationepithelial cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmentepidermis developmentepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmentepidermis developmentepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processanatomical structure developmenttissue developmentepidermis developmentepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processanatomical structure developmenttissue developmentepithelium developmentepithelial cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processcellular developmental processcell differentiationepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processcellular developmental processcell differentiationepithelial cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processdevelopmental processabscission +age-dependent behavioral declineanatomical structure development +anatomical structure formation involved in morphogenesis +anatomical structure morphogenesis +cellular developmental process +development involved in symbiotic interaction +developmental pigmentation +developmental process involved in reproduction +dormancy process +innervation +keratinization [GO:0031424] (32 genes, 32 annotations)cornificationmegagametogenesis +meristem determinacy +meristem maintenance +microgametogenesis +midbrain-hindbrain boundary maturation during brain developmentmidbrain-hindbrain boundary maturation during neural plate developmentmulticellular organismal development +muscle attachment +negative regulation of developmental process +organism emergence from protective structure +otolith tetheringpattern specification process +polyphenic determination +positive regulation of developmental process +post-embryonic development +pseudocleavage +pupariationpupationregulation of developmental process +single-organism developmental process +spore germination +stem cell maintenance +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmentepidermis developmentepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processmulticellular organismal processsingle-multicellular organism processadult behavior +age-dependent behavioral declinebeta-amyloid clearance +bud dormancy processcell recognition +circadian regulation of gene expressioncircadian regulation of heart rate +circadian regulation of translationcoagulation +cytokine production +determination of adult lifespan +digestion +hatching behaviorinnervation +keratinization [GO:0031424] (32 genes, 32 annotations)cornificationlarval behavior +megagametogenesis +meristem determinacy +meristem maintenance +microgametogenesis +midbrain-hindbrain boundary maturation during brain developmentmidbrain-hindbrain boundary maturation during neural plate developmentmolting cycle +molting cycle process +morphogenesis of a branching structure +multicellular organism adhesion +multicellular organism growth +multicellular organismal development +multicellular organismal homeostasis +multicellular organismal metabolic process +multicellular organismal movement +multicellular organismal response to stress +multicellular organismal signaling +muscle attachment +negative regulation of multicellular organismal process +neurotrophin production +organ growth +organism emergence from protective structure +ossification +otolith tetheringpattern specification process +pigment accumulation in tissues +plasma lipoprotein particle clearance +plasma lipoprotein particle organization +pollen germinationpolyphenic determination +positive regulation of multicellular organismal process +post-embryonic development +primary growthproduction of molecular mediator involved in inflammatory response +pseudocleavage +pupariationpupationregulation of body fluid levels +respiratory gaseous exchange +response to dietary excess +scab formationsecretion by tissue +seed dormancy process +seed germination +sleep +stem cell maintenance +system process +tissue migration +tissue remodeling +transforming growth factor beta activation +tropism +vascular transport +vibrational conductance of sound to the inner earvisual behavior +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmentepidermis developmentepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processsingle-organism processsingle-multicellular organism processadult behavior +age-dependent behavioral declinebeta-amyloid clearance +bud dormancy processcell recognition +circadian regulation of gene expressioncircadian regulation of heart rate +circadian regulation of translationcoagulation +cytokine production +determination of adult lifespan +digestion +hatching behaviorinnervation +keratinization [GO:0031424] (32 genes, 32 annotations)cornificationlarval behavior +megagametogenesis +meristem determinacy +meristem maintenance +microgametogenesis +midbrain-hindbrain boundary maturation during brain developmentmidbrain-hindbrain boundary maturation during neural plate developmentmolting cycle +molting cycle process +morphogenesis of a branching structure +multicellular organism adhesion +multicellular organism growth +multicellular organismal development +multicellular organismal homeostasis +multicellular organismal metabolic process +multicellular organismal movement +multicellular organismal response to stress +multicellular organismal signaling +muscle attachment +negative regulation of multicellular organismal process +neurotrophin production +organ growth +organism emergence from protective structure +ossification +otolith tetheringpattern specification process +pigment accumulation in tissues +plasma lipoprotein particle clearance +plasma lipoprotein particle organization +pollen germinationpolyphenic determination +positive regulation of multicellular organismal process +post-embryonic development +primary growthproduction of molecular mediator involved in inflammatory response +pseudocleavage +pupariationpupationregulation of body fluid levels +respiratory gaseous exchange +response to dietary excess +scab formationsecretion by tissue +seed dormancy process +seed germination +sleep +stem cell maintenance +system process +tissue migration +tissue remodeling +transforming growth factor beta activation +tropism +vascular transport +vibrational conductance of sound to the inner earvisual behavior +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmentepidermis developmentepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationepidermal cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationepithelial cell differentiationkeratinocyte differentiationkeratinization [GO:0031424] (32 genes, 32 annotations)cornificationkeratinocyte development +limb granular cell differentiation +limb spinous cell differentiation +negative regulation of keratinocyte differentiationpositive regulation of keratinocyte differentiationregulation of keratinocyte differentiation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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