Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Igfbp3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IGFBP3
- Mouse genes Igfbp3
- Rat genes Igfbp3
- Zfish genes igfbp3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igfbp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001968	fibronectin binding	Igfbp3	IDA		Mouse	PMID:19236847
Molecular Function	GO:0005520	insulin-like growth factor binding	Igfbp3	IPI	PR:P05017	Mouse	PMID:7679139
Molecular Function	GO:0031994	insulin-like growth factor I binding	IGFBP3	IPI	UniProtKB:P05019	Human	PMID:10766744
Molecular Function	GO:0031994	insulin-like growth factor I binding	igfbp3	IDA		Zfish	PMID:21558420
Molecular Function	GO:0031995	insulin-like growth factor II binding	Igfbp3	IPI	RGD:737149	Rat	PMID:9346943\|RGD:1626111
Molecular Function	GO:0031995	insulin-like growth factor II binding	igfbp3	IDA		Zfish	PMID:21558420
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q8IVG9	Human	PMID:14561895
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q86XT9	Human	PMID:20353938
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:P00533	Human	PMID:23178489
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q8IVG9	Human	PMID:26216267
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q8IVG9	Human	PMID:30184438
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:P17252	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:P61981	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q15047-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q8TAP4-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	IGFBP3	IPI	UniProtKB:P01308	Human	PMID:9388210
Molecular Function	GO:0005515	protein binding	Igfbp3	IPI	RGD:68429	Rat	PMID:9346943\|RGD:1626111
Molecular Function	GO:0008160	protein tyrosine phosphatase activator activity	IGFBP3	IDA		Human	PMID:11940579
Cellular Component	GO:0005615	extracellular space	IGFBP3	IDA		Human	PMID:17119061
Cellular Component	GO:0005615	extracellular space	Igfbp3	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Igfbp3	IDA		Mouse	PMID:7679139
Cellular Component	GO:0005615	extracellular space	Igfbp3	IDA		Mouse	PMID:7510770
Cellular Component	GO:0005615	extracellular space	Igfbp3	IDA		Rat	PMID:15990634\|RGD:1626110
Cellular Component	GO:0005615	extracellular space	Igfbp3	IDA		Rat	PMID:19382144\|RGD:2306671
Cellular Component	GO:0000792	heterochromatin	Igfbp3	IDA		Rat	PMID:15125883\|RGD:10402776
Cellular Component	GO:0042568	insulin-like growth factor binary complex	Igfbp3	IDA		Rat	PMID:9346943\|RGD:1626111
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	IGFBP3	IDA		Human	PMID:9497324
Cellular Component	GO:0042567	insulin-like growth factor ternary complex	Igfbp3	IDA		Rat	PMID:9346943\|RGD:1626111
Cellular Component	GO:0005634	nucleus	IGFBP3	IDA		Human	PMID:17434920
Cellular Component	GO:0005634	nucleus	igfbp3	IDA		Zfish	PMID:21558420
Cellular Component	GO:0031091	platelet alpha granule	Igfbp3	IDA		Rat	PMID:9449625\|RGD:10402780
Biological Process	GO:0007568	aging	Igfbp3	IEP		Rat	PMID:12397024\|RGD:729113
Biological Process	GO:0007568	aging	Igfbp3	IEP		Rat	PMID:9751511\|RGD:10402778
Biological Process	GO:0071392	cellular response to estradiol stimulus	Igfbp3	IEP		Rat	PMID:8674839\|RGD:1358947
Biological Process	GO:1904017	cellular response to Thyroglobulin triiodothyronine	Igfbp3	IEP		Rat	PMID:8674839\|RGD:1358947
Biological Process	GO:0007565	female pregnancy	Igfbp3	IEP		Rat	PMID:9449625\|RGD:10402780
Biological Process	GO:0042472	inner ear morphogenesis	igfbp3	IMP	ZFIN:ZDB-MRPHLNO-050419-1	Zfish	PMID:15550380
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	igfbp3	IEP		Zfish	PMID:14605935
Biological Process	GO:0000165	MAPK cascade	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0000165	MAPK cascade	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0010259	multicellular organism aging	Igfbp3	IEP		Rat	PMID:9492067\|RGD:152176652
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	igfbp3	IDA		Zfish	PMID:21558420
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	igfbp3	IGI	ZFIN:ZDB-MRPHLNO-050221-6,ZFIN:ZDB-MRPHLNO-050419-1	Zfish	PMID:21558420
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGFBP3	IGI	UniProtKB:P97436	Human	PMID:19258508
Biological Process	GO:0008285	negative regulation of cell population proliferation	Igfbp3	IMP		Rat	PMID:22067319\|RGD:10402755
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IGFBP3	IDA		Human	PMID:17591901
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	IGFBP3	IDA		Human	PMID:10766744
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	IGFBP3	IDA		Human	PMID:10766744
Biological Process	GO:2000844	negative regulation of testosterone secretion	Igfbp3	IMP		Rat	PMID:25582342\|RGD:12743617
Biological Process	GO:0001649	osteoblast differentiation	Igfbp3	IEP		Mouse	MGI:MGI:3828402\|PMID:16311053
Biological Process	GO:0030916	otic vesicle formation	igfbp3	IMP	ZFIN:ZDB-MRPHLNO-050419-1	Zfish	PMID:15550380
Biological Process	GO:0060037	pharyngeal system development	igfbp3	IMP	ZFIN:ZDB-MRPHLNO-050419-1	Zfish	PMID:21558420
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	Igfbp3	IMP		Rat	PMID:15125883\|RGD:10402776
Biological Process	GO:0043065	positive regulation of apoptotic process	IGFBP3	IMP		Human	PMID:11971816
Biological Process	GO:0043065	positive regulation of apoptotic process	Igfbp3	IMP		Rat	PMID:15935983\|RGD:10402766
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Igfbp3	IMP		Rat	PMID:15055478\|RGD:10402811
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0043410	positive regulation of MAPK cascade	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0043410	positive regulation of MAPK cascade	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IGFBP3	IDA		Human	PMID:12599210
Biological Process	GO:0006468	protein phosphorylation	IGFBP3	IDA		Human	PMID:17434920
Biological Process	GO:0001558	regulation of cell growth	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0001558	regulation of cell growth	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0010906	regulation of glucose metabolic process	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0010906	regulation of glucose metabolic process	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0040008	regulation of growth	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0040008	regulation of growth	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541
Biological Process	GO:0061771	response to caloric restriction	Igfbp3	IEP		Rat	PMID:17635417\|RGD:12743612
Biological Process	GO:0060416	response to growth hormone	Igfbp3	IEP		Rat	PMID:19916171\|RGD:12743620
Biological Process	GO:0001666	response to hypoxia	Igfbp3	IEP		Rat	PMID:22805023\|RGD:12743618
Biological Process	GO:0032868	response to insulin	Igfbp3	IEP		Rat	PMID:8776722\|RGD:12743615
Biological Process	GO:1990418	response to insulin-like growth factor stimulus	Igfbp3	IEP		Rat	PMID:8776722\|RGD:12743615
Biological Process	GO:0032496	response to lipopolysaccharide	Igfbp3	IEP		Rat	PMID:15930173\|RGD:12743621
Biological Process	GO:0014070	response to organic cyclic compound	Igfbp3	IEP		Rat	PMID:7536658\|RGD:152176653
Biological Process	GO:0009410	response to xenobiotic stimulus	Igfbp3	IEP		Rat	PMID:20042659\|RGD:12743613
Biological Process	GO:0001501	skeletal system development	igfbp3	IMP	ZFIN:ZDB-MRPHLNO-050419-1	Zfish	PMID:15550380
Biological Process	GO:0044342	type B pancreatic cell proliferation	Igfbp3	IGI	MGI:MGI:96440	Mouse	PMID:16675541
Biological Process	GO:0044342	type B pancreatic cell proliferation	Igfbp3	IGI	MGI:MGI:96439	Mouse	PMID:16675541

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.