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Igfbp3
Gene Detail
 Symbol
Name
ID
Igfbp3
insulin-like growth factor binding protein 3
MGI:96438
Synonyms IGFBP-3
Feature Type protein coding gene
Genetic Map
Chromosome 11
4.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:7206086-7213923 bp, - strand
From VEGA annotation of GRCm38

  7838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp3

Human
homologs
Human Homolog IGFBP3, insulin-like growth factor binding protein 3
NCBI Gene ID 3486
neXtProt AC  NX_P17936
Human Synonyms  BP-53, IBP3
Human Chr (Location)  7p13-p12; chr7:45912245-45921272 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for one knock-out allele exhibit normal body weight. Mice homozygous for another knock-out allele exhibit increased body weight, and show altered hepatic carbohydrate and lipid metabolism when fed a high-fat diet.
 
Interactions
Igfbp3 interacts with 240 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process negative regulation of cell proliferation, negative regulation of protein phosphorylation, ...
Component extracellular region, extracellular space, ...
Function fibronectin binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (65)    Tissues (52)    Images (5)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 17
Northern blot 19
RT-PCR 29
cDNA source data(137)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) Genomic(5) cDNA(137) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005135 (Evidence)
Ensembl Gene ModelENSMUSG00000020427 (Evidence)
Entrez Gene16009 (Evidence)
UniGene29254
DFCITC1574593, TC1604772, TC1615779
DoTSDT.101719142, DT.97343456, DT.97381081
NIA Mouse Gene IndexU032502, U058944
Consensus CDS ProjectCCDS24428.1
International Mouse Knockout Project StatusIgfbp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005135 VEGA Gene Model | MGI Sequence Detail 7838 C57BL/6J ±  kb
transcript OTTMUST00000011488 VEGA | MGI Sequence Detail 1709 Not Applicable 
polypeptide OTTMUSP00000049576 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR012211 Insulin-like growth factor binding protein 3
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008949 insulin-like growth factor-binding protein 3
References (Earliest) J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
(Latest) J:203301 Chin YP, et al., Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology. 2013 Oct;154(10):3739-44
All references(102)
Other
accession IDs
MGD-MRK-11235, MGI:2144251

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory