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Igfbp3
Gene Detail
Symbol

Name
ID
Igfbp3
insulin-like growth factor binding protein 3
MGI:96438
Synonyms
IGFBP-3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
4.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:7206086-7213923 bp, - strand
From VEGA annotation of GRCm38

  7838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:500  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: IGFBP3
Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp3

Human
homologs
IGFBP3, insulin-like growth factor binding protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3486
neXtProt AC: NX_P17936

Human Synonyms: BP-53, IBP3

Human Chr (Location): 7p12.3; chr7:45912245-45921272 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Incidental mutations (data from APF )
 
Mice homozygous for one knock-out allele exhibit normal body weight. Mice homozygous for another knock-out allele exhibit increased body weight, and show altered hepatic carbohydrate and lipid metabolism when fed a high-fat diet.
 
Interactions
Igfbp3 interacts with 240 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (36 records)
Data Summary: Results (59)    Tissues (50)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
Northern blot 19
RT-PCR 23
cDNA source data(137)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN igfbp3    NEW 
Molecular
reagents
All nucleic(148) Genomic(5) cDNA(137) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005135 (Evidence)
Ensembl Gene Model ENSMUSG00000020427 (Evidence)
Entrez Gene 16009 (Evidence)
UniGene 29254
DFCI TC1574593, TC1604772, TC1615779
DoTS DT.101719142, DT.97343456, DT.97381081
NIA Mouse Gene Index U032502, U058944
Consensus CDS Project CCDS24428.1
International Mouse Phenotyping Consortium Status Igfbp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005135 VEGA Gene Model | MGI Sequence Detail 7838 C57BL/6J ±  kb
transcript OTTMUST00000011487 VEGA | MGI Sequence Detail 2421 Not Applicable 
polypeptide OTTMUSP00000005343 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR012211 Insulin-like growth factor binding protein 3
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008949 insulin-like growth factor-binding protein 3
References
(Earliest) J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
(Latest) J:220756 Nguyen KH, et al., Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability. Endocrinology. 2015 Feb;156(2):462-74
All references(105)
Other
accession IDs
MGD-MRK-11235, MGI:2144251

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory