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Igfbp3 Gene Detail
Summary
  • Symbol
    Igfbp3
  • Name
    insulin-like growth factor binding protein 3
  • Synonyms
    IGFBP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96438
    NCBI Gene: 16009
  • Gene Overview
    MyGene.info: IGFBP3
Location & Maps
more
  • Genetic Map
    Chromosome 11, 4.75 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    IGFBP3, insulin like growth factor binding protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IGFBP3, insulin like growth factor binding protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BP-53, IBP3
  • Links
    NCBI Gene ID: 3486
    neXtProt AC: NX_P17936

  • Chr Location
    7p12.3; chr7:45912245-45921272 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    6
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for one knock-out allele exhibit normal body weight. Mice homozygous for another knock-out allele exhibit increased body weight, and show altered hepatic carbohydrate and lipid metabolism when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005135 VEGA Gene Model | MGI Sequence Detail 7838 C57BL/6J ±  kb
transcript OTTMUST00000011487 VEGA | MGI Sequence Detail 2421 Not Applicable  
polypeptide OTTMUSP00000005343 VEGA | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008949 insulin-like growth factor-binding protein 3
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR009168 Insulin-like growth factor binding protein
    IPR012211 Insulin-like growth factor binding protein 3
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
Molecular
Reagents
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  • All nucleic 148
    Genomic 5
    cDNA 137
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11235, MGI:2144251
References
more
  • Summaries
    All 104
    Developmental Gene Expression 38
    Gene Ontology 12
    Phenotypes 19
  • Earliest
    J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
  • Latest
    J:220756 Nguyen KH, et al., Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability. Endocrinology. 2015 Feb;156(2):462-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory