Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables fibronectin binding activity and insulin-like growth factor binding activity. Involved in osteoblast differentiation. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).