| GO term: | platelet alpha granule |
| Synonym: | platelet alpha-granule |
| GO id: | GO:0031091 |
| Definition: | A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). |
| Number of paths to term: | 21 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
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membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcellcell partintracellularintracellular partintracellular organellecytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcellcell partintracellularintracellular partintracellular organelleintracellular membrane-bounded organellecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcellcell partintracellular partcytoplasmcytoplasmic partcytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcellcell partintracellular partcytoplasmic partcytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcellcell partintracellular partintracellular organellecytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcellcell partintracellular partintracellular organelleintracellular membrane-bounded organellecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellularintracellular partcytoplasmcytoplasmic partcytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellularintracellular partcytoplasmic partcytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellularintracellular partintracellular organellecytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellularintracellular partintracellular organelleintracellular membrane-bounded organellecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellular partcytoplasmcytoplasmic partcytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellular partcytoplasmic partcytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellular partintracellular organellecytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentcell partintracellular partintracellular organelleintracellular membrane-bounded organellecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentorganelleintracellular organellecytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentorganelleintracellular organelleintracellular membrane-bounded organellecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentorganellemembrane-bounded organelleintracellular membrane-bounded organellecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentorganellevesiclecytoplasmic vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +cellular_componentorganellevesiclemembrane-bounded vesiclecytoplasmic membrane-bounded vesiclesecretory granuleacrosomal vesicle +azurophil granule +chromaffin granule +cortical granuledense core granule +insulin-responsive compartmentlamellar body +mucocystplatelet alpha granule [GO:0031091] (14 genes, 15 annotations)platelet alpha granule lumenplatelet alpha granule membraneplatelet dense granule +secretory granule lumen +secretory granule membrane +specific granule +tertiary granule +Weibel-Palade bodyzymogen granule +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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