Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ICAM1
  • Mouse genes Icam1
  • Rat genes Icam1
  • Zfish genes icam3,sc:d0202,si:ch211-66e2.3,si:ch73-208g10.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Icam1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	ICAM1	IPI	UniProtKB:P11215	Human	PMID:12208882
Molecular Function	GO:0005178	integrin binding	ICAM1	IPI	UniProtKB:P20701	Human	PMID:12208882
Molecular Function	GO:0005178	integrin binding	ICAM1	IPI	UniProtKB:P20701	Human	PMID:1448173
Molecular Function	GO:0005178	integrin binding	ICAM1	IDA		Human	PMID:23620790
Molecular Function	GO:0005178	integrin binding	Icam1	IMP		Rat	PMID:16825578|RGD:1582375
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:P20701	Human	PMID:12526797
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:Q9UHI5	Human	PMID:12716892
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:P20701	Human	PMID:16595626
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:P20701	Human	PMID:22956999
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:P60033	Human	PMID:23858057
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:Q14145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:Q99828	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:Q9BRX2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ICAM1	IPI	UniProtKB:P02679	Human	PMID:7822297
Molecular Function	GO:0044877	protein-containing complex binding	Icam1	IPI	RGD:631424|RGD:1305581	Rat	PMID:10556544|RGD:4145434
Cellular Component	GO:0009986	cell surface	ICAM1	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	ICAM1	HDA		Human	PMID:23981064
Cellular Component	GO:0009986	cell surface	Icam1	IDA		Rat	PMID:15474526|RGD:151665813
Cellular Component	GO:0009986	cell surface	Icam1	IDA		Rat	PMID:31723344|RGD:152176657
Cellular Component	GO:0009986	cell surface	Icam1	IDA		Rat	PMID:8938183|RGD:1625386
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ICAM1	HDA		Human	PMID:27559042
Cellular Component	GO:0009897	external side of plasma membrane	Icam1	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Icam1	IDA		Mouse	PMID:18684012
Cellular Component	GO:0070062	extracellular exosome	ICAM1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ICAM1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ICAM1	IDA		Human	PMID:21276792
Cellular Component	GO:0005615	extracellular space	ICAM1	IDA		Human	PMID:9290466
Cellular Component	GO:0005615	extracellular space	Icam1	IDA		Rat	PMID:18413153|RGD:2306987
Cellular Component	GO:0005925	focal adhesion	ICAM1	HDA		Human	PMID:21423176
Cellular Component	GO:0001772	immunological synapse	Icam1	IDA		Mouse	MGI:MGI:6838590|PMID:27359298
Cellular Component	GO:0001772	immunological synapse	Icam1	IDA		Mouse	PMID:14973438
Cellular Component	GO:0016020	membrane	ICAM1	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	Icam1	IDA		Mouse	MGI:MGI:5605955|PMID:12763482
Cellular Component	GO:0005886	plasma membrane	Icam1	IDA		Rat	PMID:15087287|RGD:1358663
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	Icam1	IMP		Rat	PMID:7641842|RGD:8158119
Biological Process	GO:0044406	adhesion of symbiont to host	ICAM1	IDA		Human	PMID:2538243
Biological Process	GO:0060048	cardiac muscle contraction	icam3	IMP	ZFIN:ZDB-GENO-190411-12	Zfish	PMID:29777134
Biological Process	GO:0007155	cell adhesion	ICAM1	IDA		Human	PMID:16809613
Biological Process	GO:0007155	cell adhesion	Icam1	IDA		Mouse	PMID:15249579
Biological Process	GO:0007155	cell adhesion	Icam1	IDA		Mouse	PMID:10528208
Biological Process	GO:0033627	cell adhesion mediated by integrin	Icam1	IDA		Mouse	PMID:10601245
Biological Process	GO:0098609	cell-cell adhesion	Icam1	IDA		Rat	PMID:12097510|RGD:628354
Biological Process	GO:0098609	cell-cell adhesion	Icam1	IMP		Rat	PMID:8938183|RGD:1625386
Biological Process	GO:0071312	cellular response to alkaloid	Icam1	IEP		Rat	PMID:20674665|RGD:4145373
Biological Process	GO:1904646	cellular response to amyloid-beta	ICAM1	IDA		Human	PMID:11078691
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Icam1	IEP		Rat	PMID:10976991|RGD:11520786
Biological Process	GO:0071333	cellular response to glucose stimulus	Icam1	IDA		Mouse	PMID:17670746
Biological Process	GO:0071333	cellular response to glucose stimulus	Icam1	IEP		Rat	PMID:20627932|RGD:4145381
Biological Process	GO:0071456	cellular response to hypoxia	Icam1	IEP		Rat	PMID:20631551|RGD:8662392
Biological Process	GO:0071347	cellular response to interleukin-1	Icam1	IEP		Rat	PMID:20643106|RGD:4145376
Biological Process	GO:0071354	cellular response to interleukin-6	Icam1	IEP		Rat	PMID:7865494|RGD:11520781
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Icam1	IEP		Mouse	PMID:20439489
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Icam1	IEP		Rat	PMID:20674665|RGD:4145373
Biological Process	GO:0031669	cellular response to nutrient levels	Icam1	IEP		Rat	PMID:20643106|RGD:4145376
Biological Process	GO:0071310	cellular response to organic substance	Icam1	IEP		Rat	PMID:20870297|RGD:4145347
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Icam1	IEP		Rat	PMID:15087287|RGD:1358663
Biological Process	GO:0071346	cellular response to type II interferon	Icam1	IEP		Rat	PMID:7865494|RGD:11520781
Biological Process	GO:0090398	cellular senescence	Icam1	IEP		Rat	PMID:20421514|RGD:4145420
Biological Process	GO:0061028	establishment of endothelial barrier	ICAM1	IGI	UniProtKB:Q96S97	Human	PMID:23264465
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	Icam1	IMP		Rat	PMID:10201790|RGD:11520782
Biological Process	GO:0097368	establishment of Sertoli cell barrier	Icam1	IDA		Rat	PMID:22976294|RGD:8547721
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ICAM1	IMP		Human	PMID:2477710
Biological Process	GO:0007159	leukocyte cell-cell adhesion	Icam1	IMP		Mouse	PMID:8562500
Biological Process	GO:0050900	leukocyte migration	ICAM1	IEP		Human	PMID:12082081
Biological Process	GO:0022614	membrane to membrane docking	ICAM1	IEP		Human	PMID:12082081
Biological Process	GO:0051926	negative regulation of calcium ion transport	Icam1	IDA		Rat	PMID:15087287|RGD:1358663
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ICAM1	IDA		Human	PMID:10903502
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ICAM1	IDA		Human	PMID:10903502
Biological Process	GO:0001541	ovarian follicle development	Icam1	IEP		Rat	PMID:20591976|RGD:4145386
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Icam1	IDA		Rat	PMID:17662049|RGD:7240703
Biological Process	GO:0002693	positive regulation of cellular extravasation	ICAM1	IMP		Human	PMID:12902516
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ICAM1	IMP		Human	PMID:10903502
Biological Process	GO:0043547	positive regulation of GTPase activity	Icam1	IDA		Rat	PMID:17662049|RGD:7240703
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	Icam1	IMP		Rat	PMID:10517906|RGD:11520788
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Icam1	IMP		Rat	PMID:9062344|RGD:1600239
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Icam1	IMP		Rat	PMID:9062344|RGD:1600239
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Icam1	IDA		Rat	PMID:17662049|RGD:7240703
Biological Process	GO:0045907	positive regulation of vasoconstriction	Icam1	IMP		Rat	PMID:12296653|RGD:4145431
Biological Process	GO:0046813	receptor-mediated virion attachment to host cell	ICAM1	IDA		Human	PMID:2538243
Biological Process	GO:0008360	regulation of cell shape	Icam1	IMP		Rat	PMID:15087287|RGD:1358663
Biological Process	GO:1900027	regulation of ruffle assembly	Icam1	IDA		Mouse	PMID:23372835
Biological Process	GO:0043200	response to amino acid	Icam1	IEP		Rat	PMID:20599905|RGD:4145385
Biological Process	GO:0001975	response to amphetamine	Icam1	IEP		Rat	PMID:21093552|RGD:4889145
Biological Process	GO:0046688	response to copper ion	Icam1	IEP		Rat	PMID:20544302|RGD:4145394
Biological Process	GO:0045471	response to ethanol	Icam1	IEP		Rat	PMID:20726338|RGD:4145369
Biological Process	GO:0034698	response to gonadotropin	Icam1	IEP		Rat	PMID:20591976|RGD:4145386
Biological Process	GO:0001666	response to hypoxia	Icam1	IEP		Rat	PMID:19823174|RGD:4145499
Biological Process	GO:0032868	response to insulin	Icam1	IEP		Rat	PMID:18791499|RGD:2308944
Biological Process	GO:0010212	response to ionizing radiation	Icam1	IEP		Rat	PMID:20385203|RGD:4145425
Biological Process	GO:0032496	response to lipopolysaccharide	Icam1	IEP		Rat	PMID:20871155|RGD:4145345
Biological Process	GO:0014070	response to organic cyclic compound	Icam1	IEP		Rat	PMID:20740350|RGD:4145367
Biological Process	GO:0010477	response to sulfur dioxide	Icam1	IEP		Rat	PMID:20951496|RGD:4145333
Biological Process	GO:0009410	response to xenobiotic stimulus	Icam1	IEP		Rat	PMID:20871620|RGD:4145344
Biological Process	GO:0009410	response to xenobiotic stimulus	Icam1	IEP		Rat	PMID:29091898|RGD:15090820
Biological Process	GO:0007605	sensory perception of sound	Icam1	IMP		Rat	PMID:19213042|RGD:8547577
Biological Process	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ICAM1	IMP		Human	PMID:2477710
Biological Process	GO:0002457	T cell antigen processing and presentation	Icam1	IDA		Mouse	PMID:2479693
Biological Process	GO:0072683	T cell extravasation	Icam1	IMP		Mouse	PMID:17344467
Biological Process	GO:0055015	ventricular cardiac muscle cell development	icam3	IMP	ZFIN:ZDB-GENO-190411-12	Zfish	PMID:29777134

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern