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Icam1 Gene Detail
Summary
  • Symbol
    Icam1
  • Name
    intercellular adhesion molecule 1
  • Synonyms
    CD54, Icam-1, Ly-47, MALA-2, MGC:6195
  • Feature Type
    protein coding gene
  • IDs
    MGI:96392
    NCBI Gene: 15894
  • Gene Overview
    MyGene.info: ICAM1
Location & Maps
more
  • Sequence Map
    Chr9:21015960-21028797 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12838 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.69 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    ICAM1, intercellular adhesion molecule 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ICAM1, intercellular adhesion molecule 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BB2, CD54, P3.58
  • Links
    NCBI Gene ID: 3383
    neXtProt AC: NX_P05362

  • Chr Location
    19p13.2; chr19:10270841-10286615 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Icam1 mouse models; 1 with human ICAM1 associations

Human Disease Mouse Models
       Malaria, Susceptibility to   OMIM: 611162 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 4 alleles in 10 genetic backgrounds
    36 phenotypes from multigenic genotypes
    200 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired inflammatory and immune responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15894 NCBI Gene Model | MGI Sequence Detail 12838 C57BL/6J ±  kb
transcript NM_010493 RefSeq | MGI Sequence Detail 2593 C57BL/6  
polypeptide P13597 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000001467 intercellular adhesion molecule 1
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003988 Intercellular adhesion molecule
    IPR013768 Intercellular adhesion molecule, N-terminal
    IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
Molecular
Reagents
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  • All nucleic 48
    Genomic 5
    cDNA 40
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11146, MGD-MRK-11148, MGD-MRK-11989
References
more
  • Summaries
    All 375
    Developmental Gene Expression 32
    Diseases 2
    Gene Ontology 16
    Phenotypes 200
  • Earliest
    J:9934 Ballantyne CM, et al., Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1). Nucleic Acids Res. 1989 Jul 25;17(14):5853
  • Latest
    J:232503 Woodfin A, et al., ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. Blood. 2016 Feb 18;127(7):898-907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory