Icam1
Gene Detail

Symbol Name ID

Icam1 intercellular adhesion molecule 1 MGI:96392

Synonyms

CD54, Icam-1, Ly-47, MALA-2, MGC:6195

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr9:21015960-21028797 bp, + strand From NCBI annotation of GRCm38   12838 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: intercellular adhesion molecule, ICAM-1 type
Gene Tree: Icam1

Human homologs

Human Homolog		ICAM1, intercellular adhesion molecule 1
NCBI Gene ID		3383
neXtProt AC		NX_P05362
Human Synonyms		BB2, CD54, P3.58
Human Chr (Location)		19p13.3-p13.2; chr19:10381517-10397291 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ICAM1

Alleles and phenotypes

All alleles(21) : Targeted(5) Gene trapped(16)
 

Homozygous mutation of this gene results in impaired inflammatory and immune responses.

 
Human Diseases Modeled Using Mouse Icam1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	adhesion to symbiont, cell adhesion, ...
Component	cell surface, external side of plasma membrane, ...
Function	cell surface binding, integrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (33)    Tissues (8)    Images (20)
Theiler Stages: 19, 22, 23

Assay Type	Results
Immunohistochemistry	4
RNA in situ	25
RT-PCR	4

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(5) cDNA(40) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000037405 (Evidence)
Entrez Gene	15894 (Evidence)
DFCI	TC1571893
Consensus CDS Project	CCDS22889.1
International Mouse Knockout Project Status	Icam1

Sequences

Length	Strain/Species
genomic	15894	NCBI Gene Model | MGI Sequence Detail	12838	C57BL/6J
transcript	NM_010493	RefSeq | MGI Sequence Detail	2540	BALB/c
polypeptide	P13597	UniProt | EBI | MGI Sequence Detail	537	Not Applicable

All sequences(52) RefSeq(2) UniProt(13)

Polymorphisms

RFLP(6) : SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003988	Intercellular adhesion molecule
InterPro	IPR013768	Intercellular adhesion molecule, N-terminal
InterPro	IPR003987	Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
Protein Ontology	PR:000001467	intercellular adhesion molecule 1

Graphical View of Protein Domain Structure

References

(Earliest) J:9934 Ballantyne CM, et al., Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1). Nucleic Acids Res. 1989 Jul 25;17(14):5853
(Latest) J:195308 Reichardt P, et al., A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. EMBO J. 2013 Mar 20;32(6):829-43
All references(351)

Other accession IDs

MGD-MRK-11146, MGD-MRK-11148, MGD-MRK-11989