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Icam1
Gene Detail
 Symbol
Name
ID
Icam1
intercellular adhesion molecule 1
MGI:96392
Synonyms CD54, Icam-1, Ly-47, MALA-2, MGC:6195
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr9:21015960-21028797 bp, + strand
From NCBI annotation of GRCm38

  12838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: intercellular adhesion molecule, ICAM-1 type
Gene Tree: Icam1

Human
homologs
Human Homolog ICAM1, intercellular adhesion molecule 1
NCBI Gene ID 3383
neXtProt AC  NX_P05362
Human Synonyms  BB2, CD54, P3.58
Human Chr (Location)  19p13.3-p13.2; chr19:10270841-10286615 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ICAM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(16) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired inflammatory and immune responses.
 
Human Diseases Modeled Using Mouse Icam1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Icam1 interacts with 143 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process acute inflammatory response to antigenic stimulus, adhesion of symbiont to host, ...
Component cell surface, external side of plasma membrane, ...
Function integrin binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (39)    Tissues (10)    Images (20)
Theiler Stages: 19, 22, 23, 26
Assay TypeResults
Immunohistochemistry 8
RNA in situ 25
RT-PCR 6
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(5) cDNA(40) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037405 (Evidence)
Entrez Gene15894 (Evidence)
DFCITC1571893
Consensus CDS ProjectCCDS22889.1
International Mouse Knockout Project StatusIcam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15894 NCBI Gene Model | MGI Sequence Detail 12838 C57BL/6J ±  kb
transcript NM_010493 RefSeq | MGI Sequence Detail 2540 BALB/c 
polypeptide P13597 UniProt | EBI | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(13)
Polymorphisms RFLP(6) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003988 Intercellular adhesion molecule
InterPro IPR013768 Intercellular adhesion molecule, N-terminal
InterPro IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
Protein Ontology PR:000001467 intercellular adhesion molecule 1
Graphical View of Protein Domain Structure
References (Earliest) J:9934 Ballantyne CM, et al., Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1). Nucleic Acids Res. 1989 Jul 25;17(14):5853
(Latest) J:209375 Bullard DC, et al., Expression of a single ICAM-1 isoform on T cells is sufficient for development of experimental autoimmune encephalomyelitis. Eur J Immunol. 2014 Apr;44(4):1194-9
All references(365)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11146, MGD-MRK-11148, MGD-MRK-11989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory