Phenotypes Associated with This Genotype

Genotype
MGI:3622779

• Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr; Tg(INS-Il10)#Sar/0
• Genetic Background: NOD.Cg-Icam1^tm1Jcgr Tg(INS-Il10)#Sar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

periinsulitis ( J:66103 )

• ICAM-I deficient transgenic mice develop periinsulitis but not insulitis as do wild-type transgenic NOD mice

decreased susceptibility to autoimmune diabetes ( J:66103 )

• wild-type transgenic NOD mice readily develop diabetes starting at 5 weeks (blood glucose >300 mg/dl), while ICAM-I deficient transgenic NOD mice have not developed diabetes at 12 weeks (n=4) or 16 weeks (n=5); nontransgenic ICAM-I deficient mice do not develop diabetes over the same period

• transfer of concanavalin A treated splenocytes from 8 week old Tg(TcraBDC2.5)1Doi Tg(TcraBDC2.5)1Doi female mice expressing an islet-specific TCR transgene to irradiated ICAM-I deficient NOD or deficient transgenic NOD mice does not induce diabetes in recipients

endocrine/exocrine glands

periinsulitis ( J:66103 )

• ICAM-I deficient transgenic mice develop periinsulitis but not insulitis as do wild-type transgenic NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:98583