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Gene Ontology Browser
Term Detail
GO term:immunological synapse
Synonym: c-SMAC
Synonym: supramolecular activation cluster
GO id:GO:0001772
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell periphery
                                        part-ofplasma membrane
                                                part-ofplasma membrane part
                                                        is-acell body membrane +
                                                        is-acell trailing edge membrane +
                                                        is-acellular bud membrane
                                                        is-acytoplasmic side of plasma membrane +
                                                        is-acytoproct
                                                        is-acytostome
                                                        is-aexternal side of plasma membrane +
                                                        is-aextrinsic component of plasma membrane +
                                                        is-agrowth cone membrane
                                                        is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                                        is-aintracellular canaliculus
                                                        is-aintrinsic component of plasma membrane +
                                                        is-alateral plasma membrane
                                                        is-aleading edge membrane +
                                                        is-amating projection tip membrane
                                                        is-amedial membrane band
                                                        is-amesosome
                                                        is-aorthogonal array
                                                        is-aphagocytic cup +
                                                        is-aphagocytic cup base
                                                        is-aphagocytic cup lip
                                                        is-aplasma membrane of cell tip
                                                        is-aplasma membrane of growing cell tip
                                                        is-aplasma membrane part of cell junction
                                                        is-aplasma membrane part of cell-substrate junction. +
                                                        is-aplasma membrane protein complex +
                                                        is-aplasma membrane region +
                                                        is-aplasma membrane respiratory chain +
                                                        is-aplasma membrane-derived thylakoid lumen
                                                        is-aplasmodesmatal cytoplasmic sleeve
                                                        is-aplasmodesmatal desmotubule +
                                                        is-aplasmodesmatal endoplasmic reticulum
                                                        is-aplasmodesmatal plasma membrane
                                                        is-aporosome
                                                        is-asubapical complex
                                                        is-asubplasmalemmal coating
                                                        is-aT-tubule +
                                                        is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aplasma membrane
                                        part-ofplasma membrane part
                                                is-acell body membrane +
                                                is-acell trailing edge membrane +
                                                is-acellular bud membrane
                                                is-acytoplasmic side of plasma membrane +
                                                is-acytoproct
                                                is-acytostome
                                                is-aexternal side of plasma membrane +
                                                is-aextrinsic component of plasma membrane +
                                                is-agrowth cone membrane
                                                is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                                is-aintracellular canaliculus
                                                is-aintrinsic component of plasma membrane +
                                                is-alateral plasma membrane
                                                is-aleading edge membrane +
                                                is-amating projection tip membrane
                                                is-amedial membrane band
                                                is-amesosome
                                                is-aorthogonal array
                                                is-aphagocytic cup +
                                                is-aphagocytic cup base
                                                is-aphagocytic cup lip
                                                is-aplasma membrane of cell tip
                                                is-aplasma membrane of growing cell tip
                                                is-aplasma membrane part of cell junction
                                                is-aplasma membrane part of cell-substrate junction. +
                                                is-aplasma membrane protein complex +
                                                is-aplasma membrane region +
                                                is-aplasma membrane respiratory chain +
                                                is-aplasma membrane-derived thylakoid lumen
                                                is-aplasmodesmatal cytoplasmic sleeve
                                                is-aplasmodesmatal desmotubule +
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-aplasmodesmatal plasma membrane
                                                is-aporosome
                                                is-asubapical complex
                                                is-asubplasmalemmal coating
                                                is-aT-tubule +
                                                is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aplasma membrane part
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-agrowth cone membrane
                                        is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of cell tip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell periphery
                                part-ofplasma membrane
                                        part-ofplasma membrane part
                                                is-acell body membrane +
                                                is-acell trailing edge membrane +
                                                is-acellular bud membrane
                                                is-acytoplasmic side of plasma membrane +
                                                is-acytoproct
                                                is-acytostome
                                                is-aexternal side of plasma membrane +
                                                is-aextrinsic component of plasma membrane +
                                                is-agrowth cone membrane
                                                is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                                is-aintracellular canaliculus
                                                is-aintrinsic component of plasma membrane +
                                                is-alateral plasma membrane
                                                is-aleading edge membrane +
                                                is-amating projection tip membrane
                                                is-amedial membrane band
                                                is-amesosome
                                                is-aorthogonal array
                                                is-aphagocytic cup +
                                                is-aphagocytic cup base
                                                is-aphagocytic cup lip
                                                is-aplasma membrane of cell tip
                                                is-aplasma membrane of growing cell tip
                                                is-aplasma membrane part of cell junction
                                                is-aplasma membrane part of cell-substrate junction. +
                                                is-aplasma membrane protein complex +
                                                is-aplasma membrane region +
                                                is-aplasma membrane respiratory chain +
                                                is-aplasma membrane-derived thylakoid lumen
                                                is-aplasmodesmatal cytoplasmic sleeve
                                                is-aplasmodesmatal desmotubule +
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-aplasmodesmatal plasma membrane
                                                is-aporosome
                                                is-asubapical complex
                                                is-asubplasmalemmal coating
                                                is-aT-tubule +
                                                is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aplasma membrane
                                part-ofplasma membrane part
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-agrowth cone membrane
                                        is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of cell tip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aplasma membrane part
                                is-acell body membrane +
                                is-acell trailing edge membrane +
                                is-acellular bud membrane
                                is-acytoplasmic side of plasma membrane +
                                is-acytoproct
                                is-acytostome
                                is-aexternal side of plasma membrane +
                                is-aextrinsic component of plasma membrane +
                                is-agrowth cone membrane
                                is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                is-aintracellular canaliculus
                                is-aintrinsic component of plasma membrane +
                                is-alateral plasma membrane
                                is-aleading edge membrane +
                                is-amating projection tip membrane
                                is-amedial membrane band
                                is-amesosome
                                is-aorthogonal array
                                is-aphagocytic cup +
                                is-aphagocytic cup base
                                is-aphagocytic cup lip
                                is-aplasma membrane of cell tip
                                is-aplasma membrane of growing cell tip
                                is-aplasma membrane part of cell junction
                                is-aplasma membrane part of cell-substrate junction. +
                                is-aplasma membrane protein complex +
                                is-aplasma membrane region +
                                is-aplasma membrane respiratory chain +
                                is-aplasma membrane-derived thylakoid lumen
                                is-aplasmodesmatal cytoplasmic sleeve
                                is-aplasmodesmatal desmotubule +
                                is-aplasmodesmatal endoplasmic reticulum
                                is-aplasmodesmatal plasma membrane
                                is-aporosome
                                is-asubapical complex
                                is-asubplasmalemmal coating
                                is-aT-tubule +
                                is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aplasma membrane part
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-agrowth cone membrane
                                        is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of cell tip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        is-aplasma membrane
                                part-ofplasma membrane part
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-agrowth cone membrane
                                        is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of cell tip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aplasma membrane part
                                is-acell body membrane +
                                is-acell trailing edge membrane +
                                is-acellular bud membrane
                                is-acytoplasmic side of plasma membrane +
                                is-acytoproct
                                is-acytostome
                                is-aexternal side of plasma membrane +
                                is-aextrinsic component of plasma membrane +
                                is-agrowth cone membrane
                                is-aimmunological synapse [GO:0001772] (32 genes, 38 annotations)
                                is-aintracellular canaliculus
                                is-aintrinsic component of plasma membrane +
                                is-alateral plasma membrane
                                is-aleading edge membrane +
                                is-amating projection tip membrane
                                is-amedial membrane band
                                is-amesosome
                                is-aorthogonal array
                                is-aphagocytic cup +
                                is-aphagocytic cup base
                                is-aphagocytic cup lip
                                is-aplasma membrane of cell tip
                                is-aplasma membrane of growing cell tip
                                is-aplasma membrane part of cell junction
                                is-aplasma membrane part of cell-substrate junction. +
                                is-aplasma membrane protein complex +
                                is-aplasma membrane region +
                                is-aplasma membrane respiratory chain +
                                is-aplasma membrane-derived thylakoid lumen
                                is-aplasmodesmatal cytoplasmic sleeve
                                is-aplasmodesmatal desmotubule +
                                is-aplasmodesmatal endoplasmic reticulum
                                is-aplasmodesmatal plasma membrane
                                is-aporosome
                                is-asubapical complex
                                is-asubplasmalemmal coating
                                is-aT-tubule +
                                is-atetraspanin-enriched microdomain


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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory