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Gene Ontology Browser
Term Detail
GO term:immunological synapse
Synonym: c-SMAC
Synonym: supramolecular activation cluster
GO id:GO:0001772
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell periphery
                                        part-ofplasma membrane
                                                part-ofplasma membrane part
                                                        is-a1,3-beta-D-glucan synthase complex
                                                        is-acell body membrane +
                                                        is-acell trailing edge membrane +
                                                        is-acellular bud membrane
                                                        is-aCus cation efflux complex
                                                        is-acytoplasmic side of plasma membrane +
                                                        is-acytoproct
                                                        is-acytostome
                                                        is-aD-amino-acid dehydrogenase complex
                                                        is-aEmrE multidrug transporter complex
                                                        is-aexternal side of plasma membrane +
                                                        is-aextrinsic component of plasma membrane +
                                                        is-aglycine-gated chloride channel complex
                                                        is-agrowth cone membrane
                                                        is-ahydrogen:potassium-exchanging ATPase complex
                                                        is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                                        is-aintracellular canaliculus
                                                        is-aintrinsic component of plasma membrane +
                                                        is-alateral plasma membrane
                                                        is-aleading edge membrane +
                                                        is-amating projection tip membrane
                                                        is-aMdtBC Complex
                                                        is-amedial membrane band
                                                        is-amesosome
                                                        is-aNADPH oxidase complex
                                                        is-aorthogonal array
                                                        is-aphagocytic cup +
                                                        is-aphagocytic cup base
                                                        is-aphagocytic cup lip
                                                        is-aplasma membrane of growing cell tip
                                                        is-aplasma membrane part of cell junction
                                                        is-aplasma membrane part of cell-substrate junction. +
                                                        is-aplasma membrane protein complex +
                                                        is-aplasma membrane receptor complex +
                                                        is-aplasma membrane region +
                                                        is-aplasma membrane respiratory chain +
                                                        is-aplasma membrane succinate dehydrogenase complex +
                                                        is-aplasma membrane-derived thylakoid lumen
                                                        is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                                        is-aplasmodesmatal cytoplasmic sleeve
                                                        is-aplasmodesmatal desmotubule +
                                                        is-aplasmodesmatal endoplasmic reticulum
                                                        is-aplasmodesmatal plasma membrane
                                                        is-aporosome
                                                        is-asodium:potassium-exchanging ATPase complex
                                                        is-asubapical complex
                                                        is-asubplasmalemmal coating
                                                        is-asucrase-isomaltase complex
                                                        is-aT-tubule +
                                                        is-atetraspanin-enriched microdomain
                                                        is-avoltage-gated calcium channel complex +
                                                        is-avoltage-gated potassium channel complex +
                                                        is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aplasma membrane
                                        part-ofplasma membrane part
                                                is-a1,3-beta-D-glucan synthase complex
                                                is-acell body membrane +
                                                is-acell trailing edge membrane +
                                                is-acellular bud membrane
                                                is-aCus cation efflux complex
                                                is-acytoplasmic side of plasma membrane +
                                                is-acytoproct
                                                is-acytostome
                                                is-aD-amino-acid dehydrogenase complex
                                                is-aEmrE multidrug transporter complex
                                                is-aexternal side of plasma membrane +
                                                is-aextrinsic component of plasma membrane +
                                                is-aglycine-gated chloride channel complex
                                                is-agrowth cone membrane
                                                is-ahydrogen:potassium-exchanging ATPase complex
                                                is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                                is-aintracellular canaliculus
                                                is-aintrinsic component of plasma membrane +
                                                is-alateral plasma membrane
                                                is-aleading edge membrane +
                                                is-amating projection tip membrane
                                                is-aMdtBC Complex
                                                is-amedial membrane band
                                                is-amesosome
                                                is-aNADPH oxidase complex
                                                is-aorthogonal array
                                                is-aphagocytic cup +
                                                is-aphagocytic cup base
                                                is-aphagocytic cup lip
                                                is-aplasma membrane of growing cell tip
                                                is-aplasma membrane part of cell junction
                                                is-aplasma membrane part of cell-substrate junction. +
                                                is-aplasma membrane protein complex +
                                                is-aplasma membrane receptor complex +
                                                is-aplasma membrane region +
                                                is-aplasma membrane respiratory chain +
                                                is-aplasma membrane succinate dehydrogenase complex +
                                                is-aplasma membrane-derived thylakoid lumen
                                                is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                                is-aplasmodesmatal cytoplasmic sleeve
                                                is-aplasmodesmatal desmotubule +
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-aplasmodesmatal plasma membrane
                                                is-aporosome
                                                is-asodium:potassium-exchanging ATPase complex
                                                is-asubapical complex
                                                is-asubplasmalemmal coating
                                                is-asucrase-isomaltase complex
                                                is-aT-tubule +
                                                is-atetraspanin-enriched microdomain
                                                is-avoltage-gated calcium channel complex +
                                                is-avoltage-gated potassium channel complex +
                                                is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aplasma membrane part
                                        is-a1,3-beta-D-glucan synthase complex
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-aCus cation efflux complex
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aD-amino-acid dehydrogenase complex
                                        is-aEmrE multidrug transporter complex
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-aglycine-gated chloride channel complex
                                        is-agrowth cone membrane
                                        is-ahydrogen:potassium-exchanging ATPase complex
                                        is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-aMdtBC Complex
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aNADPH oxidase complex
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane receptor complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane succinate dehydrogenase complex +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asodium:potassium-exchanging ATPase complex
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-asucrase-isomaltase complex
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain
                                        is-avoltage-gated calcium channel complex +
                                        is-avoltage-gated potassium channel complex +
                                        is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell periphery
                                part-ofplasma membrane
                                        part-ofplasma membrane part
                                                is-a1,3-beta-D-glucan synthase complex
                                                is-acell body membrane +
                                                is-acell trailing edge membrane +
                                                is-acellular bud membrane
                                                is-aCus cation efflux complex
                                                is-acytoplasmic side of plasma membrane +
                                                is-acytoproct
                                                is-acytostome
                                                is-aD-amino-acid dehydrogenase complex
                                                is-aEmrE multidrug transporter complex
                                                is-aexternal side of plasma membrane +
                                                is-aextrinsic component of plasma membrane +
                                                is-aglycine-gated chloride channel complex
                                                is-agrowth cone membrane
                                                is-ahydrogen:potassium-exchanging ATPase complex
                                                is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                                is-aintracellular canaliculus
                                                is-aintrinsic component of plasma membrane +
                                                is-alateral plasma membrane
                                                is-aleading edge membrane +
                                                is-amating projection tip membrane
                                                is-aMdtBC Complex
                                                is-amedial membrane band
                                                is-amesosome
                                                is-aNADPH oxidase complex
                                                is-aorthogonal array
                                                is-aphagocytic cup +
                                                is-aphagocytic cup base
                                                is-aphagocytic cup lip
                                                is-aplasma membrane of growing cell tip
                                                is-aplasma membrane part of cell junction
                                                is-aplasma membrane part of cell-substrate junction. +
                                                is-aplasma membrane protein complex +
                                                is-aplasma membrane receptor complex +
                                                is-aplasma membrane region +
                                                is-aplasma membrane respiratory chain +
                                                is-aplasma membrane succinate dehydrogenase complex +
                                                is-aplasma membrane-derived thylakoid lumen
                                                is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                                is-aplasmodesmatal cytoplasmic sleeve
                                                is-aplasmodesmatal desmotubule +
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-aplasmodesmatal plasma membrane
                                                is-aporosome
                                                is-asodium:potassium-exchanging ATPase complex
                                                is-asubapical complex
                                                is-asubplasmalemmal coating
                                                is-asucrase-isomaltase complex
                                                is-aT-tubule +
                                                is-atetraspanin-enriched microdomain
                                                is-avoltage-gated calcium channel complex +
                                                is-avoltage-gated potassium channel complex +
                                                is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aplasma membrane
                                part-ofplasma membrane part
                                        is-a1,3-beta-D-glucan synthase complex
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-aCus cation efflux complex
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aD-amino-acid dehydrogenase complex
                                        is-aEmrE multidrug transporter complex
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-aglycine-gated chloride channel complex
                                        is-agrowth cone membrane
                                        is-ahydrogen:potassium-exchanging ATPase complex
                                        is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-aMdtBC Complex
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aNADPH oxidase complex
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane receptor complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane succinate dehydrogenase complex +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asodium:potassium-exchanging ATPase complex
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-asucrase-isomaltase complex
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain
                                        is-avoltage-gated calcium channel complex +
                                        is-avoltage-gated potassium channel complex +
                                        is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aplasma membrane part
                                is-a1,3-beta-D-glucan synthase complex
                                is-acell body membrane +
                                is-acell trailing edge membrane +
                                is-acellular bud membrane
                                is-aCus cation efflux complex
                                is-acytoplasmic side of plasma membrane +
                                is-acytoproct
                                is-acytostome
                                is-aD-amino-acid dehydrogenase complex
                                is-aEmrE multidrug transporter complex
                                is-aexternal side of plasma membrane +
                                is-aextrinsic component of plasma membrane +
                                is-aglycine-gated chloride channel complex
                                is-agrowth cone membrane
                                is-ahydrogen:potassium-exchanging ATPase complex
                                is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                is-aintracellular canaliculus
                                is-aintrinsic component of plasma membrane +
                                is-alateral plasma membrane
                                is-aleading edge membrane +
                                is-amating projection tip membrane
                                is-aMdtBC Complex
                                is-amedial membrane band
                                is-amesosome
                                is-aNADPH oxidase complex
                                is-aorthogonal array
                                is-aphagocytic cup +
                                is-aphagocytic cup base
                                is-aphagocytic cup lip
                                is-aplasma membrane of growing cell tip
                                is-aplasma membrane part of cell junction
                                is-aplasma membrane part of cell-substrate junction. +
                                is-aplasma membrane protein complex +
                                is-aplasma membrane receptor complex +
                                is-aplasma membrane region +
                                is-aplasma membrane respiratory chain +
                                is-aplasma membrane succinate dehydrogenase complex +
                                is-aplasma membrane-derived thylakoid lumen
                                is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                is-aplasmodesmatal cytoplasmic sleeve
                                is-aplasmodesmatal desmotubule +
                                is-aplasmodesmatal endoplasmic reticulum
                                is-aplasmodesmatal plasma membrane
                                is-aporosome
                                is-asodium:potassium-exchanging ATPase complex
                                is-asubapical complex
                                is-asubplasmalemmal coating
                                is-asucrase-isomaltase complex
                                is-aT-tubule +
                                is-atetraspanin-enriched microdomain
                                is-avoltage-gated calcium channel complex +
                                is-avoltage-gated potassium channel complex +
                                is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aplasma membrane part
                                        is-a1,3-beta-D-glucan synthase complex
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-aCus cation efflux complex
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aD-amino-acid dehydrogenase complex
                                        is-aEmrE multidrug transporter complex
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-aglycine-gated chloride channel complex
                                        is-agrowth cone membrane
                                        is-ahydrogen:potassium-exchanging ATPase complex
                                        is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-aMdtBC Complex
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aNADPH oxidase complex
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane receptor complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane succinate dehydrogenase complex +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asodium:potassium-exchanging ATPase complex
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-asucrase-isomaltase complex
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain
                                        is-avoltage-gated calcium channel complex +
                                        is-avoltage-gated potassium channel complex +
                                        is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        is-aplasma membrane
                                part-ofplasma membrane part
                                        is-a1,3-beta-D-glucan synthase complex
                                        is-acell body membrane +
                                        is-acell trailing edge membrane +
                                        is-acellular bud membrane
                                        is-aCus cation efflux complex
                                        is-acytoplasmic side of plasma membrane +
                                        is-acytoproct
                                        is-acytostome
                                        is-aD-amino-acid dehydrogenase complex
                                        is-aEmrE multidrug transporter complex
                                        is-aexternal side of plasma membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-aglycine-gated chloride channel complex
                                        is-agrowth cone membrane
                                        is-ahydrogen:potassium-exchanging ATPase complex
                                        is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                        is-aintracellular canaliculus
                                        is-aintrinsic component of plasma membrane +
                                        is-alateral plasma membrane
                                        is-aleading edge membrane +
                                        is-amating projection tip membrane
                                        is-aMdtBC Complex
                                        is-amedial membrane band
                                        is-amesosome
                                        is-aNADPH oxidase complex
                                        is-aorthogonal array
                                        is-aphagocytic cup +
                                        is-aphagocytic cup base
                                        is-aphagocytic cup lip
                                        is-aplasma membrane of growing cell tip
                                        is-aplasma membrane part of cell junction
                                        is-aplasma membrane part of cell-substrate junction. +
                                        is-aplasma membrane protein complex +
                                        is-aplasma membrane receptor complex +
                                        is-aplasma membrane region +
                                        is-aplasma membrane respiratory chain +
                                        is-aplasma membrane succinate dehydrogenase complex +
                                        is-aplasma membrane-derived thylakoid lumen
                                        is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                        is-aplasmodesmatal cytoplasmic sleeve
                                        is-aplasmodesmatal desmotubule +
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-aplasmodesmatal plasma membrane
                                        is-aporosome
                                        is-asodium:potassium-exchanging ATPase complex
                                        is-asubapical complex
                                        is-asubplasmalemmal coating
                                        is-asucrase-isomaltase complex
                                        is-aT-tubule +
                                        is-atetraspanin-enriched microdomain
                                        is-avoltage-gated calcium channel complex +
                                        is-avoltage-gated potassium channel complex +
                                        is-avoltage-gated sodium channel complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aplasma membrane part
                                is-a1,3-beta-D-glucan synthase complex
                                is-acell body membrane +
                                is-acell trailing edge membrane +
                                is-acellular bud membrane
                                is-aCus cation efflux complex
                                is-acytoplasmic side of plasma membrane +
                                is-acytoproct
                                is-acytostome
                                is-aD-amino-acid dehydrogenase complex
                                is-aEmrE multidrug transporter complex
                                is-aexternal side of plasma membrane +
                                is-aextrinsic component of plasma membrane +
                                is-aglycine-gated chloride channel complex
                                is-agrowth cone membrane
                                is-ahydrogen:potassium-exchanging ATPase complex
                                is-aimmunological synapse [GO:0001772] (35 genes, 43 annotations)
                                is-aintracellular canaliculus
                                is-aintrinsic component of plasma membrane +
                                is-alateral plasma membrane
                                is-aleading edge membrane +
                                is-amating projection tip membrane
                                is-aMdtBC Complex
                                is-amedial membrane band
                                is-amesosome
                                is-aNADPH oxidase complex
                                is-aorthogonal array
                                is-aphagocytic cup +
                                is-aphagocytic cup base
                                is-aphagocytic cup lip
                                is-aplasma membrane of growing cell tip
                                is-aplasma membrane part of cell junction
                                is-aplasma membrane part of cell-substrate junction. +
                                is-aplasma membrane protein complex +
                                is-aplasma membrane receptor complex +
                                is-aplasma membrane region +
                                is-aplasma membrane respiratory chain +
                                is-aplasma membrane succinate dehydrogenase complex +
                                is-aplasma membrane-derived thylakoid lumen
                                is-aplasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
                                is-aplasmodesmatal cytoplasmic sleeve
                                is-aplasmodesmatal desmotubule +
                                is-aplasmodesmatal endoplasmic reticulum
                                is-aplasmodesmatal plasma membrane
                                is-aporosome
                                is-asodium:potassium-exchanging ATPase complex
                                is-asubapical complex
                                is-asubplasmalemmal coating
                                is-asucrase-isomaltase complex
                                is-aT-tubule +
                                is-atetraspanin-enriched microdomain
                                is-avoltage-gated calcium channel complex +
                                is-avoltage-gated potassium channel complex +
                                is-avoltage-gated sodium channel complex


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory