Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HNRNPU
  • Mouse genes Hnrnpu
  • Rat genes Hnrnpu
  • Zfish genes hnrnpua,hnrnpub
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hnrnpu

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	HNRNPU	IDA		Human	PMID:15711563
Molecular Function	GO:0005524	ATP binding	HNRNPU	IDA		Human	PMID:28622508
Molecular Function	GO:0003682	chromatin binding	HNRNPU	IDA		Human	PMID:11909954
Molecular Function	GO:0003682	chromatin binding	HNRNPU	IDA		Human	PMID:28622508
Molecular Function	GO:0003682	chromatin binding	HNRNPU	IDA		Human	PMID:9405365
Molecular Function	GO:0031490	chromatin DNA binding	HNRNPU	IDA		Human	PMID:11003645
Molecular Function	GO:0003677	DNA binding	HNRNPU	IDA		Human	PMID:9204873
Molecular Function	GO:0003690	double-stranded DNA binding	HNRNPU	IDA		Human	PMID:8068679
Molecular Function	GO:0003690	double-stranded DNA binding	HNRNPU	IDA		Human	PMID:8174554
Molecular Function	GO:0003725	double-stranded RNA binding	HNRNPU	IDA		Human	PMID:8174554
Molecular Function	GO:0042802	identical protein binding	HNRNPU	IDA		Human	PMID:28622508
Molecular Function	GO:0106222	lncRNA binding	Hnrnpu	IDA		Mouse	PMID:25921091
Molecular Function	GO:0003730	mRNA 3'-UTR binding	HNRNPU	IDA		Human	PMID:17174306
Molecular Function	GO:0008143	poly(A) binding	HNRNPU	IDA		Human	PMID:8174554
Molecular Function	GO:0017130	poly(C) RNA binding	HNRNPU	IDA		Human	PMID:8174554
Molecular Function	GO:0034046	poly(G) binding	HNRNPU	IDA		Human	PMID:8174554
Molecular Function	GO:0034046	poly(G) binding	Hnrnpu	IDA		Rat	PMID:20554522|RGD:10058983
Molecular Function	GO:0036002	pre-mRNA binding	HNRNPU	IDA		Human	PMID:22325991
Molecular Function	GO:1990841	promoter-specific chromatin binding	Hnrnpu	IDA		Mouse	MGI:MGI:5908336|PMID:21235343
Molecular Function	GO:1990841	promoter-specific chromatin binding	Hnrnpu	IDA		Rat	PMID:19632204|RGD:10059314
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q09472	Human	PMID:11909954
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q9NZI8	Human	PMID:17289661
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q99697-2	Human	PMID:19174163
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P45973	Human	PMID:19617346
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q15303	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:O14965	Human	PMID:21242313
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P19338	Human	PMID:21242313
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q9ULW0	Human	PMID:21242313
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P42771	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q14103	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q8IWS0	Human	PMID:22720776
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q9UHD9	Human	PMID:25616961
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:O14965	Human	PMID:25986610
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P53350	Human	PMID:25986610
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q9ULW0	Human	PMID:25986610
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q14103	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q8TDN6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P09429	Human	PMID:29721183
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q14103	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q8TDN6	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P09429	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P61978	Human	PMID:33174841
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P20023	Human	PMID:7753047
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:P49335	Human	PMID:9105675
Molecular Function	GO:0005515	protein binding	HNRNPU	IPI	UniProtKB:Q00839	Human	PMID:9353307
Molecular Function	GO:0005515	protein binding	Hnrnpu	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5009503|PMID:19129230
Molecular Function	GO:0005515	protein binding	Hnrnpu	IPI	UniProtKB:Q3TKT4	Mouse	MGI:MGI:5532913|PMID:22162999
Molecular Function	GO:0005515	protein binding	Hnrnpu	IPI	UniProtKB:Q64321	Mouse	MGI:MGI:5912851|PMID:28784777
Molecular Function	GO:0005515	protein binding	Hnrnpu	IPI	PR:P11416-1	Mouse	PMID:18495661
Molecular Function	GO:0005515	protein binding	Hnrnpu	IPI	UniProtKB:Q14TE9	Rat	PMID:20554522|RGD:10058983
Molecular Function	GO:0005515	protein binding	Hnrnpu	IPI	UniProtKB:D4A5I9	Rat	PMID:29293066|RGD:150521645
Molecular Function	GO:0044877	protein-containing complex binding	HNRNPU	IDA		Human	PMID:19617346
Molecular Function	GO:0043021	ribonucleoprotein complex binding	HNRNPU	IDA		Human	PMID:19617346
Molecular Function	GO:0043021	ribonucleoprotein complex binding	Hnrnpu	IPI	RGD:1586156	Rat	PMID:20554522|RGD:10058983
Molecular Function	GO:0003723	RNA binding	HNRNPU	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:18082603
Molecular Function	GO:0003723	RNA binding	HNRNPU	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	HNRNPU	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	HNRNPU	IDA		Human	PMID:23811339
Molecular Function	GO:0003723	RNA binding	HNRNPU	IPI	RNAcentral:URS00002F3F76_9606	Human	PMID:24463464
Molecular Function	GO:0003723	RNA binding	HNRNPU	IDA		Human	PMID:26244333
Molecular Function	GO:0003723	RNA binding	HNRNPU	IDA		Human	PMID:28622508
Molecular Function	GO:0003723	RNA binding	Hnrnpu	IDA		Mouse	MGI:MGI:4831049|PMID:20833368
Molecular Function	GO:0003723	RNA binding	Hnrnpu	IDA		Mouse	MGI:MGI:5912851|PMID:28784777
Molecular Function	GO:0003723	RNA binding	Hnrnpu	IDA		Mouse	MGI:MGI:5908528|PMID:26244333
Molecular Function	GO:0003723	RNA binding	Hnrnpu	IPI	MGI:MGI:1924437	Mouse	PMID:25921091
Molecular Function	GO:0003723	RNA binding	Hnrnpu	IDA		Rat	PMID:20554522|RGD:10058983
Molecular Function	GO:0099122	RNA polymerase II C-terminal domain binding	Hnrnpu	IDA		Mouse	MGI:MGI:5908336|PMID:21235343
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Hnrnpu	IDA		Mouse	MGI:MGI:3794926|PMID:18332112
Molecular Function	GO:0000993	RNA polymerase II complex binding	HNRNPU	IDA		Human	PMID:10490622
Molecular Function	GO:0043565	sequence-specific DNA binding	Hnrnpu	IDA		Mouse	MGI:MGI:5908336|PMID:21235343
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HNRNPU	IDA		Human	PMID:11003645
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HNRNPU	IDA		Human	PMID:9405365
Molecular Function	GO:0003697	single-stranded DNA binding	HNRNPU	IDA		Human	PMID:1628625
Molecular Function	GO:0003697	single-stranded DNA binding	HNRNPU	IDA		Human	PMID:8068679
Molecular Function	GO:0003697	single-stranded DNA binding	HNRNPU	IDA		Human	PMID:8174554
Molecular Function	GO:0003727	single-stranded RNA binding	HNRNPU	IDA		Human	PMID:1628625
Molecular Function	GO:0003727	single-stranded RNA binding	HNRNPU	IDA		Human	PMID:8068679
Molecular Function	GO:0017069	snRNA binding	HNRNPU	IDA		Human	PMID:22325991
Molecular Function	GO:0070034	telomerase RNA binding	HNRNPU	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:18082603
Molecular Function	GO:0001097	TFIIH-class transcription factor complex binding	HNRNPU	IDA		Human	PMID:10490622
Molecular Function	GO:0003714	transcription corepressor activity	HNRNPU	IMP		Human	PMID:19617346
Molecular Function	GO:0003714	transcription corepressor activity	HNRNPU	IMP		Human	PMID:23811339
Cellular Component	GO:0071013	catalytic step 2 spliceosome	HNRNPU	IDA		Human	PMID:11991638
Cellular Component	GO:0009986	cell surface	HNRNPU	IDA		Human	PMID:7993898
Cellular Component	GO:0005813	centrosome	HNRNPU	IDA		Human	PMID:25986610
Cellular Component	GO:0070937	CRD-mediated mRNA stability complex	HNRNPU	IPI		Human	PMID:19029303
Cellular Component	GO:0070937	CRD-mediated mRNA stability complex	HNRNPU	IDA		Human	PMID:19029303
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	HNRNPU	IDA		Human	PMID:15121898
Cellular Component	GO:0005829	cytosol	HNRNPU	IDA		Human	PMID:19029303
Cellular Component	GO:0030425	dendrite	Hnrnpu	IDA		Mouse	MGI:MGI:3530979|PMID:15312650
Cellular Component	GO:0032839	dendrite cytoplasm	Hnrnpu	IDA		Mouse	MGI:MGI:3530979|PMID:15312650
Cellular Component	GO:0098577	inactive sex chromosome	HNRNPU	IDA		Human	PMID:14608463
Cellular Component	GO:0098577	inactive sex chromosome	Hnrnpu	IDA		Mouse	MGI:MGI:4831049|PMID:20833368
Cellular Component	GO:0000776	kinetochore	HNRNPU	IDA		Human	PMID:21242313
Cellular Component	GO:0016020	membrane	HNRNPU	HDA		Human	PMID:16210410
Cellular Component	GO:0016020	membrane	HNRNPU	HDA		Human	PMID:19946888
Cellular Component	GO:0030496	midbody	HNRNPU	IDA		Human	PMID:25986610
Cellular Component	GO:0072686	mitotic spindle	HNRNPU	IDA		Human	PMID:21242313
Cellular Component	GO:0072686	mitotic spindle	HNRNPU	IDA		Human	PMID:25986610
Cellular Component	GO:1990498	mitotic spindle microtubule	HNRNPU	IDA		Human	PMID:21242313
Cellular Component	GO:1990023	mitotic spindle midzone	HNRNPU	IDA		Human	PMID:21242313
Cellular Component	GO:0000228	nuclear chromosome	HNRNPU	IDA		Human	PMID:11003645
Cellular Component	GO:0016363	nuclear matrix	HNRNPU	IDA		Human	PMID:14608463
Cellular Component	GO:0016363	nuclear matrix	HNRNPU	IDA		Human	PMID:8174554
Cellular Component	GO:0016607	nuclear speck	HNRNPU	IDA		Human	PMID:9353307
Cellular Component	GO:0005654	nucleoplasm	HNRNPU	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	HNRNPU	IDA		Human	PMID:28221134
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:11003645
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:14608463
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:19617346
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:21242313
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:22720776
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:9353307
Cellular Component	GO:0005634	nucleus	HNRNPU	IDA		Human	PMID:9405365
Cellular Component	GO:0005634	nucleus	Hnrnpu	IDA		Mouse	MGI:MGI:3794926|PMID:18332112
Cellular Component	GO:0005634	nucleus	Hnrnpu	IDA		Mouse	MGI:MGI:5532913|PMID:22162999
Cellular Component	GO:0005634	nucleus	Hnrnpu	IDA		Rat	PMID:20554522|RGD:10058983
Cellular Component	GO:0032991	protein-containing complex	HNRNPU	IDA		Human	PMID:11909954
Cellular Component	GO:0032991	protein-containing complex	HNRNPU	IDA		Human	PMID:19617346
Cellular Component	GO:0032991	protein-containing complex	HNRNPU	IDA		Human	PMID:8174554
Cellular Component	GO:0032991	protein-containing complex	HNRNPU	IDA		Human	PMID:9204873
Cellular Component	GO:1990904	ribonucleoprotein complex	HNRNPU	IDA		Human	PMID:11909954
Cellular Component	GO:1990904	ribonucleoprotein complex	HNRNPU	IDA		Human	PMID:17289661
Cellular Component	GO:1990904	ribonucleoprotein complex	HNRNPU	IDA		Human	PMID:19617346
Cellular Component	GO:1990904	ribonucleoprotein complex	HNRNPU	IDA		Human	PMID:9405365
Cellular Component	GO:1990904	ribonucleoprotein complex	Hnrnpu	IDA		Mouse	PMID:25921091
Cellular Component	GO:1990904	ribonucleoprotein complex	Hnrnpu	IDA		Rat	PMID:12855701|RGD:10059306
Cellular Component	GO:1990904	ribonucleoprotein complex	Hnrnpu	IDA		Rat	PMID:20554522|RGD:10058983
Cellular Component	GO:0005697	telomerase holoenzyme complex	HNRNPU	IDA		Human	PMID:18082603
Biological Process	GO:1990845	adaptive thermogenesis	Hnrnpu	IMP		Mouse	MGI:MGI:5912851|PMID:28784777
Biological Process	GO:0055013	cardiac muscle cell development	Hnrnpu	IMP	MGI:MGI:2182095,MGI:MGI:5648110	Mouse	PMID:26039991
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Hnrnpu	IDA		Rat	PMID:19632204|RGD:10059314
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	HNRNPU	IDA		Human	PMID:9353307
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Hnrnpu	IDA		Mouse	MGI:MGI:5908336|PMID:21235343
Biological Process	GO:0032922	circadian regulation of gene expression	Hnrnpu	IDA		Mouse	MGI:MGI:3794926|PMID:18332112
Biological Process	GO:0070934	CRD-mediated mRNA stabilization	HNRNPU	IDA		Human	PMID:19029303
Biological Process	GO:0070934	CRD-mediated mRNA stabilization	HNRNPU	IMP		Human	PMID:19029303
Biological Process	GO:0098963	dendritic transport of messenger ribonucleoprotein complex	Hnrnpu	IDA		Mouse	PMID:15312650
Biological Process	GO:0098963	dendritic transport of messenger ribonucleoprotein complex	Hnrnpu	IMP		Mouse	PMID:15312650
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	Hnrnpu	IMP		Mouse	MGI:MGI:4831049|PMID:20833368
Biological Process	GO:0051457	maintenance of protein location in nucleus	HNRNPU	IMP		Human	PMID:19617346
Biological Process	GO:0016071	mRNA metabolic process	Hnrnpu	IMP		Mouse	PMID:25921091
Biological Process	GO:0048255	mRNA stabilization	HNRNPU	IDA		Human	PMID:17174306
Biological Process	GO:0033673	negative regulation of kinase activity	HNRNPU	IMP		Human	PMID:10490622
Biological Process	GO:1900152	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	HNRNPU	IDA		Human	PMID:19029303
Biological Process	GO:2000737	negative regulation of stem cell differentiation	HNRNPU	IMP		Human	PMID:21235343
Biological Process	GO:2000737	negative regulation of stem cell differentiation	Hnrnpu	IMP		Mouse	MGI:MGI:5908336|PMID:21235343
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	HNRNPU	IMP		Human	PMID:18082603
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HNRNPU	IMP		Human	PMID:9353307
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	HNRNPU	IMP		Human	PMID:10490622
Biological Process	GO:0001649	osteoblast differentiation	HNRNPU	HDA		Human	PMID:16210410
Biological Process	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	HNRNPU	IMP		Human	PMID:21242313
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Hnrnpu	IMP		Mouse	MGI:MGI:5912851|PMID:28784777
Biological Process	GO:2000767	positive regulation of cytoplasmic translation	HNRNPU	IDA		Human	PMID:19029303
Biological Process	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	Hnrnpu	IDA		Rat	PMID:20554522|RGD:10058983
Biological Process	GO:0010628	positive regulation of gene expression	Hnrnpu	IMP		Rat	PMID:20554522|RGD:10058983
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Hnrnpu	IMP		Mouse	MGI:MGI:4831049|PMID:20833368
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HNRNPU	IMP		Human	PMID:15711563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnrnpu	IDA		Mouse	MGI:MGI:5532913|PMID:22162999
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Hnrnpu	IMP		Mouse	MGI:MGI:5908336|PMID:21235343
Biological Process	GO:1902889	protein localization to spindle microtubule	HNRNPU	IMP		Human	PMID:21242313
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	HNRNPU	IDA		Human	PMID:22325991
Biological Process	GO:1902275	regulation of chromatin organization	HNRNPU	IMP		Human	PMID:28622508
Biological Process	GO:0007346	regulation of mitotic cell cycle	HNRNPU	IMP		Human	PMID:25986610
Biological Process	GO:1901673	regulation of mitotic spindle assembly	HNRNPU	IMP		Human	PMID:21242313
Biological Process	GO:1990280	RNA localization to chromatin	Hnrnpu	IMP		Mouse	MGI:MGI:4831049|PMID:20833368

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern