About   Help   FAQ
Hnrnpu Gene Detail
Summary
  • Symbol
    Hnrnpu
  • Name
    heterogeneous nuclear ribonucleoprotein U
  • Synonyms
    Hnrpu, scaffold attachment factor A, Sp120
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858195
    NCBI Gene: 51810
  • Gene Overview
    MyGene.info: HNRNPU
Location & Maps
more
  • Sequence Map
    Chr1:178321108-178337797 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      16690 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 83.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HNRNPU, heterogeneous nuclear ribonucleoprotein U
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HNRNPU, heterogeneous nuclear ribonucleoprotein U
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE54, hnRNP U, HNRNPU-AS1, HNRPU, pp120, SAFA, SAF-A, U21.1
  • Links
    NCBI Gene ID: 3192
    neXtProt AC: NX_Q00839
    UniProt: Q00839

  • Chr Location
    1q44; chr1:244842123-244864720 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display embryonic lethality, delayed embryonic development, and failure of chorioallantoic fusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    27
  • Tissues
    27
  • cDNA Data
    29
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021881 VEGA Gene Model | MGI Sequence Detail 16690 C57BL/6J ±  kb
transcript OTTMUST00000051942 VEGA | MGI Sequence Detail 7640 Not Applicable  
polypeptide OTTMUSP00000024527 VEGA | MGI Sequence Detail 800 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 29
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138082, MGI:2138186, MGI:2138396, MGI:2138400, MGI:2138619, MGI:2138718
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
  • Latest
    J:223139 Ye J, et al., hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory