Hnrnpu
Gene Detail

Symbol Name ID

Hnrnpu heterogeneous nuclear ribonucleoprotein U MGI:1858195

Synonyms

Hnrpu, scaffold attachment factor A, Sp120

Feature Type

protein coding gene

Genetic Map

Chromosome 1

83.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:178323074-178337797 bp, - strand From VEGA annotation of GRCm38   14724 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22991  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Hnrnpu

Human homologs

Human Homolog		HNRNPU, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
NCBI Gene ID		3192
neXtProt AC		NX_Q00839
Human Synonyms		hnRNP U, HNRPU, SAF-A, U21.1
Human Chr (Location)		1q44; chr1:244850300-244864525 (-)  GRCh38

Alleles and phenotypes

All alleles(47) : Gene trapped(44) Targeted(3)
Incidental mutations (data from Mutagenetix )
 

Mice homozygous for a gene trap allele display embryonic lethality, delayed embryonic development, and failure of chorioallantoic fusion.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	CRD-mediated mRNA stabilization, mRNA processing, ...
Component	catalytic step 2 spliceosome, CRD-mediated mRNA stability complex, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (27)    Tissues (27)    Images (6)
Theiler Stages: 9, 11, 14, 15, 22

Assay Type	Results
RNA in situ	23
RT-PCR	4

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021881 (Evidence)
Ensembl Gene Model	ENSMUSG00000039630 (Evidence)
Entrez Gene	51810 (Evidence)
Consensus CDS Project	CCDS35804.1
International Mouse Knockout Project Status	Hnrnpu

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021881	VEGA Gene Model | MGI Sequence Detail	14724	C57BL/6J
transcript	OTTMUST00000051942	VEGA | MGI Sequence Detail	3878	Not Applicable
polypeptide	OTTMUSP00000024527	VEGA | MGI Sequence Detail	800	Not Applicable

All sequences(65) RefSeq(3) UniProt(10)

Polymorphisms

SNPs within 2kb(45 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001870	B30.2/SPRY domain
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR026745	Heterogeneous nuclear ribonucleoprotein U
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR003034	SAP domain
InterPro	IPR003877	SPla/RYanodine receptor SPRY
InterPro	IPR018355	SPla/RYanodine receptor subgroup
Protein Ontology	PR:000008673	heterogeneous nuclear ribonucleoprotein U

References

(Earliest) J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
(Latest) J:185205 Heisig J, et al., Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012 May;8(5):e1002728
All references(43)

Other accession IDs

MGI:2138082, MGI:2138186, MGI:2138396, MGI:2138400, MGI:2138619, MGI:2138718