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Hnrnpu
Gene Detail
Symbol

Name
ID
Hnrnpu
heterogeneous nuclear ribonucleoprotein U
MGI:1858195
Synonyms
Hnrpu, scaffold attachment factor A, Sp120
Feature Type
protein coding gene
Genetic Map
Chromosome 1
83.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:178324343-178337797 bp, - strand
From VEGA annotation of GRCm38

  13455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22991  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Hnrnpu

Human
homologs
Human Homolog HNRNPU, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
NCBI Gene ID 3192
neXtProt AC  NX_Q00839
Human Synonyms  hnRNP U, HNRPU, SAF-A, U21.1
Human Chr (Location)  1q44; chr1:244850300-244864525 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a gene trap allele display embryonic lethality, delayed embryonic development, and failure of chorioallantoic fusion.
 
Interactions
Hnrnpu interacts with 345 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process CRD-mediated mRNA stabilization, mRNA processing, ...
Component catalytic step 2 spliceosome, CRD-mediated mRNA stability complex, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (27)    Tissues (27)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
RT-PCR 4
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021881 (Evidence)
Ensembl Gene ModelENSMUSG00000039630 (Evidence)
Entrez Gene51810 (Evidence)
Consensus CDS ProjectCCDS35804.1
International Mouse Knockout Project StatusHnrnpu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021881 VEGA Gene Model | MGI Sequence Detail 13455 C57BL/6J ±  kb
transcript OTTMUST00000051942 VEGA | MGI Sequence Detail 7640 Not Applicable 
polypeptide OTTMUSP00000024527 VEGA | MGI Sequence Detail 800 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(3) UniProt(10)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR026745 Heterogeneous nuclear ribonucleoprotein U
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR003034 SAP domain
InterPro IPR003877 SPla/RYanodine receptor SPRY
InterPro IPR018355 SPla/RYanodine receptor subgroup
Protein Ontology PR:000008673 heterogeneous nuclear ribonucleoprotein U
References
(Earliest) J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
(Latest) J:185205 Heisig J, et al., Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012 May;8(5):e1002728
All references(37)
Other
accession IDs
MGI:2138082, MGI:2138186, MGI:2138396, MGI:2138400, MGI:2138619, MGI:2138718

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory