Hnrnpu MGI Mouse Gene Detail - MGI:1858195 - heterogeneous nuclear ribonucleoprotein U

Hnrnpu Gene Detail

Symbol

Hnrnpu
Name

heterogeneous nuclear ribonucleoprotein U
Synonyms

Hnrpu, scaffold attachment factor A, Sp120

Feature Type

protein coding gene
IDs

MGI:1858195
NCBI Gene: 51810
Gene Overview

MyGene.info: HNRNPU

Sequence Map

Chr1:178321108-178337797 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

16690 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 83.16 cM
Mapping Data

2 experiments

Human Ortholog

HNRNPU, heterogeneous nuclear ribonucleoprotein U

Vertebrate Orthologs

10

Human Ortholog

HNRNPU, heterogeneous nuclear ribonucleoprotein U
Orthology source: HomoloGene, HGNC
Synonyms

EIEE54, hnRNP U, HNRNPU-AS1, HNRPU, pp120, SAFA, SAF-A, U21.1
Links

HGNC:5048

NCBI Gene ID: 3192

neXtProt AC: NX_Q00839

UniProt: Q00839
Chr Location

1q44; chr1:244842123-244864720 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22991
1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HNRNPU
Gene Tree

Hnrnpu

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Phenotype Summary

23 phenotypes from 2 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
3 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Gene trapped

1
Targeted

4
Genomic Mutations

2 involving Hnrnpu
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a gene trap allele display embryonic lethality, delayed embryonic development, and failure of chorioallantoic fusion.

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All GO Annotations

86
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

27
Tissues

27
cDNA Data

29
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Hnrnpu interacts with 345 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

80
RefSeq

8
UniProt

11
CCDS

CCDS35804.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021881	VEGA Gene Model \| MGI Sequence Detail	16690	C57BL/6J	± kb
transcript	OTTMUST00000051942	VEGA \| MGI Sequence Detail	7640	Not Applicable
polypeptide	OTTMUSP00000024527	VEGA \| MGI Sequence Detail	800	Not Applicable

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SNPs within 2kb

57 from dbSNP Build 142

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UniProt

11 Sequences
Protein Ontology

PR:000008673 heterogeneous nuclear ribonucleoprotein U

(term hierarchy)
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR013320 Concanavalin A-like lectin/glucanase domain

IPR026745 Heterogeneous nuclear ribonucleoprotein U

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR003034 SAP domain

IPR003877 SPRY domain

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All nucleic 30

cDNA 29

Primer pair 1

Microarray probesets 3

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MGI:2138082, MGI:2138186, MGI:2138396, MGI:2138400, MGI:2138619, MGI:2138718

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 7
Earliest

J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
Latest

J:243474 Yamada N, et al., Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. PLoS Genet. 2015 Aug;11(8):e1005430

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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