Hnrnpu^em1Frk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hnrnpu^em1Frk
• Name: heterogeneous nuclear ribonucleoprotein U; endonuclease-mediated mutation 1, Wayne N Frankel
• MGI ID: MGI:7550686
• Synonyms: Hnrnpu^113DEL
• Gene: Hnrnpu Location: Chr1:178148673-178165362 bp, - strand Genetic Position: Chr1, 83.16 cM
• Alliance: Hnrnpu^em1Frk page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an out-of-frame 113-bp deletion in exon 1, resulting in a premature stop codon in exon 2. (J:342579)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnpu Mutation: 43 strains or lines available

References

• Original: J:342579 Dugger SA, et al., Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency. PLoS Genet. 2023 Oct;19(10):e1010952
• All: 1 reference(s)